Diagnostic differences and agreement between the original and revised European Working Group (EWGSOP) consensus definition for sarcopenia in community-dwelling older adults with type 2 diabetes mellitus

2020 ◽  
Vol 89 ◽  
pp. 104081 ◽  
Author(s):  
Anthony Villani ◽  
Rebecca McClure ◽  
Michelle Barrett ◽  
David Scott
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Type 2 Diabetes Mellitus ◽  
Working Group ◽  
Community Dwelling ◽  
Consensus Definition ◽  
European Working ◽  
Community Dwelling Older Adults

Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults

2008 ◽  
Vol 56 (6) ◽  
pp. 1028-1036 ◽  
Author(s):  
Olivia I. Okereke ◽  
Jae H. Kang ◽  
Nancy R. Cook ◽  
J. Michael Gaziano ◽  
JoAnn E. Manson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Decline ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals DPP4 Gene Polymorphism Associates With Type 2 Diabetes Mellitus in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 123-124
Author(s):  
Elisa Alves ◽  
Audrey Tonet-Furioso ◽  
Izabela D Bastos ◽  
Clayton Moraes ◽  
Otávio Nóbrega
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Type 2 Diabetes Mellitus ◽  
Glycosylated Hemoglobin ◽  
Federal District ◽  
Genetic Variations ◽  
Community Dwelling ◽  
Dipeptidyl Peptidase 4

Abstract Genetic variations of the dipeptidyl peptidase 4 enzyme (DPP-4) have been associated with glycemic disorders, especially among older adults. The objective of this study was to investigate the association of a single nucleotide polymorphism on the DPP4 gene with the occurrence of type 2 diabetes mellitus in a sample of older community-dwelling patients. Clinical, anthropometric and physiological characteristics as well as biochemical data related to lipidemia, glycemia and hormonal factors and variables related to the lifestyle were analyzed among 338 individuals aged 60 years and older from two general geriatric outpatient clinics in the Federal District, Brazil. Genotypes related to the polymorphism rs3788979 (A/G) of the DPP4 gene of these patients were determined by conventional polymerase chain reaction followed by enzymatic restriction, whereas the serum levels of DPP-4 were assessed by colorimetric immunoassay. Among the results obtained, there was clear variation in the glycemic levels both in terms of blood glucose and glycosylated hemoglobin according to DPP-4 genotypes, with increased levels between homozygotes for the G allele. However, no association was found between genotypes and occurrence of type 2 diabetes mellitus in patients. No other clinical, biochemical or anthropometric variables were influenced by the polymorphism. In our conditions, there was no association between genotypes and DPP-4 levels. Considering that DPP-4 is involved in the metabolism of incretins and directly interferes with glycemia in organisms, our result corroborates that genetic variations of this enzyme can affect glycemic homeostasis, despite not being determinant for the occurrence of type 2 diabetes mellitus.

scholarly journals Predictors of frailty among Chinese community-dwelling older adults with type 2 diabetes: a cross-sectional survey

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e041578
Author(s):  
Linglin Kong ◽  
Huimin Zhao ◽  
Junyao Fan ◽  
Quan Wang ◽  
Jie Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Community Health ◽  
Community Dwelling ◽  
Central China ◽  
Chinese Community ◽  
Cross Sectional ◽  
Community Dwelling Older Adults

ObjectivesTo assess the prevalence of frailty and identify predictors of frailty among Chinese community-dwelling older adults with type 2 diabetes.DesignA cross-sectional design.SettingTwo community health centres in central China.Participants291 community-dwelling older adults aged ≥65 years with type 2 diabetes.Main outcome measuresData were collected via face-to-face interviews, anthropometric measurements, laboratory tests and community health files. The main outcome measure was frailty, as assessed by the frailty phenotype criteria. The multivariate logistic regression model was used to identify the predictors of frailty.ResultsThe prevalence of prefrailty and frailty were 51.5% and 19.2%, respectively. The significant predictors of frailty included alcohol drinking (ex-drinker) (OR 4.461, 95% CI 1.079 to 18.438), glycated haemoglobin (OR 1.434, 95% CI 1.045 to 1.968), nutritional status (malnutrition risk/malnutrition) (OR 8.062, 95% CI 2.470 to 26.317), depressive symptoms (OR 1.438, 95% CI 1.166 to 1.773) and exercise behaviour (OR 0.796, 95% CI 0.716 to 0.884).ConclusionsA high prevalence of frailty was found among older adults with type 2 diabetes in the Chinese community. Frailty identification and multifaceted interventions should be developed for this population, taking into consideration proper glycaemic control, nutritional instruction, depressive symptoms improvement and enhancement of self-care behaviours.

The status of frailty in poor older adults with type 2 diabetes mellitus or hypertension: the case of Mexico

2019 ◽  
Vol 40 (2) ◽  
pp. 303-309
Author(s):  
Javier E. García-de-Alba-García ◽  
Ana L. Salcedo-Rocha ◽  
Susana De-la-Rosa-Hernández
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Type 2 Diabetes Mellitus ◽  
The Status
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