Overexpression of T-cadherin inhibits the proliferation of oral squamous cell carcinoma through the PI3K/AKT/mTOR intracellular signalling pathway

2018 ◽  
Vol 96 ◽  
pp. 74-79 ◽  
Author(s):  
Qiuju Wang ◽  
Xiaoqin Zhang ◽  
Xiaoyu Song ◽  
Li Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Signalling Pathway ◽  
Intracellular Signalling ◽  
Intracellular Signalling Pathway

Notch Signalling: A Potential Therapeutic Pathway in Oral Squamous Cell Carcinoma

2021 ◽  
Vol 21 ◽  
Author(s):  
Ankit Pandey ◽  
Sreeshma Bhuvanadas ◽  
Joel P. Joseph ◽  
Rama Jayaraj ◽  
Arikketh Devi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Progression ◽  
Notch Signalling ◽  
Signalling Pathway ◽  
Notch Signalling Pathway ◽  
Mortality And Morbidity ◽  
Cellular Dysfunction

: Cancer, a set of diseases characterized by abnormal cell growth resulting from alteration in the expression pattern of diverse genes, is one of the prominent cause of mortality and morbidity worldwide. This modification of various genes lead to altered signalling cascades and changes in the molecular network. These changes eventually give rise to cellular dysfunction and then to systemic failure causing death. Of the several pathways that are aberrantly activated in cancer, Notch signalling pathway is a prominent one. Notch signalling pathway is a juxtracrine signalling pathway which activates the genes associated with cell proliferation, survival and angiogenesis. Notch signalling pathway components are seen to be upregulated in several types of cancer. Oral squamous cell carcinoma (OSCC) is a predominant category of oral cancer where aberrant activation of Notch signalling causes tumour progression and metastasis. In this review, we discuss the Notch signalling pathway, its components, forms and its role in the progression and metastasis of oral squamous cell carcinoma.

scholarly journals (PI3K)/AKT signalling pathway – a Pandora’s box in oral squamous cell carcinoma

2019 ◽  
Vol 14 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Alexandra Totan ◽  
◽  
Daniela Miricescu ◽  
Iulia-Ioana Stanescu ◽  
Andreea Didilescu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Signalling Pathway

Genistein nanoformulation promotes selective apoptosis in oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway

Phytomedicine ◽  
2021 ◽  
Vol 80 ◽  
pp. 153386
Author(s):  
Atul Dev ◽  
Mohammed Nadim Sardoiwala ◽  
Avinash Chandra Kushwaha ◽  
Surajit Karmakar ◽  
Subhasree Roy Choudhury
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Signalling Pathway

scholarly journals EPHB4 Regulates the Proliferation and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF-κB Signalling Pathway

2021 ◽  
Vol 12 (20) ◽  
pp. 5999-6011
Author(s):  
Chen Yi ◽  
Xiliu Zhang ◽  
Hongyu Li ◽  
Guanhui Chen ◽  
Binghui Zeng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Signalling Pathway ◽  
Proliferation And Metastasis
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