scholarly journals Population-based Risk Factors for Elevated Alanine Aminotransferase in a South Texas Mexican–American Population

2012 ◽  
Vol 43 (6) ◽  
pp. 482-488 ◽  
Author(s):  
Hui-Qi Qu ◽  
Quan Li ◽  
Megan L. Grove ◽  
Yang Lu ◽  
Jen-Jung Pan ◽  
...  
2020 ◽  
Vol 4 (4) ◽  
pp. 555-568
Author(s):  
Suet Ying Kwan ◽  
Jingjing Jiao ◽  
Jonathan Qi ◽  
Ying Wang ◽  
Peng Wei ◽  
...  

2005 ◽  
Vol 7 (1) ◽  
pp. 1-9 ◽  
Author(s):  
John P. Elder ◽  
Shelia L. Broyles ◽  
Jesse J. Brennan ◽  
Maria Luisa Zúñiga de Nuncio ◽  
Philip R. Nader

2002 ◽  
Vol 134 (3) ◽  
pp. 390-398 ◽  
Author(s):  
Sheila K West ◽  
Beatriz Munoz ◽  
Ronald Klein ◽  
Aimee T Broman ◽  
Rosario Sanchez ◽  
...  

2012 ◽  
Vol 35 (4) ◽  
pp. 237 ◽  
Author(s):  
Quan Li ◽  
Hui-Qi Qu ◽  
Anne R. Rentfro ◽  
Megan L. Grove ◽  
Shaper Mirza ◽  
...  

Purpose: This study examined genetic associations of patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and liver aminotransferases in an extensively documented, randomly recruited Mexican American population at high risk of liver disease. Methods: Two single nucleotide polymorphisms (SNP) in the PNPLA3 gene (i.e., rs738409 and rs2281135) were genotyped in 1532 individuals. Population stratification was corrected by the genotyping of 103 ancestry informative markers (AIMs) for Mexican Americans. Results: Both PNPLA3 SNPs showed highly significant association with alanine aminotransferase (ALT) levels, but was also, in males, associated with aspartate aminotransferase (AST) levels. Haplotypic association test of the two SNPs suggested stronger genetic association with rs738409 than rs2281135. Obvious sex effects were observed: rs738409-sex interaction in ALT levels P=8.37x10-4; rs738409-sex interaction in AST levels P=5.03x10-3. Conclusions: This population study highlights a sex-specific association of PNPLA3 polymorphisms and elevated liver enzymes in a population-based study, independent of common pathological factors of the metabolic syndrome. The strong genetic association found in women≤50 years old, but not in women > 50 years old, suggests that sex hormones may mediate the sex effect.


2011 ◽  
Vol 42 (6) ◽  
pp. 523-531 ◽  
Author(s):  
Jorge Duran-Gonzalez ◽  
Ixiu Ortiz ◽  
Enrique Gonzales ◽  
Nicole Ruiz ◽  
Manti Ortiz ◽  
...  

2009 ◽  
Vol 94 (8) ◽  
pp. 3085-3088 ◽  
Author(s):  
Kiymet Bozaoglu ◽  
David Segal ◽  
Katherine A. Shields ◽  
Nik Cummings ◽  
Joanne E. Curran ◽  
...  

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Hong Seok LEE ◽  
Zhiwei Zhang ◽  
Karen Xu ◽  
Yong-Moon Park

Background: Cardiorespiratory fitness is a distinct health characteristic that relates to the ability to perform physical activity. Higher cardiorespiratory fitness was reported to have reverse relationship with overall mortality and morbidity rates due to various chronic disease. The assessment of cardiorespiratory fitness was measured by maximal oxygen uptake (VO2max; mL/kg/minute) on a submaximal treadmill test. This study was aimed to examine cardiorespiratory fitness among U.S. adults 20-49 years of age, to describe the distribution of cardiorespiratory fitness and cardiovascular risk factors depends on different ethnicity for without physical limitations or indications of cardiovascular disease. Method: Data from the 1999-2004, National Health and Nutrition Examination Survey were used to describe the distribution of cardiorespiratory fitness for adults 20-49 years of age. 8324 out of 31126 subjects have valid values of cardiopulmonary fitness in the dataset with 5391 in low category of cardiorespiratory fitness (VO 2 max < 27), 2606 in medium category (37.1 > VO 2 max ≥27) and 327 in high category (37.1 ≥ VO 2 max). The risk factors for cardiopulmonary fitness was assessed by using logistic regression after adjusting all cardiovascular risk factors. All data were analyzed using SAS Ver. 9.4. Result: Overall, there is no significant association of cardiorespiratory fitness with ethnicity ( P =0.08). 65.9% of study population was male in all races. Among, non-Hispanic whites, those with 25 m 2 /kg > BMI had better cardiorespiratory fitness (more than 37.1 mL/kg/minute) than those with BMI ≥ 35 [Odds ratio (OR): 0.496, Confidence Interval (CI): 0.258-0.957]. A similar pattern was observed for Mexican Americans. Non-Hispanic black with 25 m 2 /kg > BMI had better cardiorespiratory fitness than ones with BMI ≥ 35 m 2 /kg [OR:0.137, CI:0.059-0.318], 35 m 2 /kg > BMI≥30 m 2 /kg [OR:0.269, CI:0.124-0.583], 30 m 2 /kg > BMI≥25 m 2 /kg [OR: 0.241,0.123-0.318]. Non-Hispanic white with higher diastolic blood pressure over 90 mmHg had tendency to have lower cardiorespiratory fitness. Among metabolic panel, only Mexican American with LDL<100 mg/dl has higher cardiorespiratory fitness [OR:0.559, CI:0.319-0.981]. Discussion: Our findings on cardiorespiratory fitness level among non-Hispanic blacks, non-Hispanic whites and Mexican Americans are similar to previously reported studies, however, non-Hispanic black had different risk factors related to cardiorespiratory fitness, especially significant benefit from lower BMI less than 25 m 2 /kg since other ethnicities with BMI less than 25 m 2 /kg had benefit only compared to BMI> 35 m 2 /kg. These results can be used to improve cardiorespiratory fitness level for future population based on ethnicities. The different risk factors in fitness status can also be used to develop health policies and targeted educational campaigns.


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