scholarly journals Role of malonaldehyde as a surrogate biomarker for iron overload in the β-thalassemia patient: A systematic meta-analysis

2021 ◽  
Vol 3 ◽  
pp. 100017
Author(s):  
Debleena Basu ◽  
Debashree Guha Adhya ◽  
Rupal Sinha ◽  
Nishant Chakravorty
2020 ◽  
Author(s):  
Praveen Parthasarathy

BACKGROUND The role of iron overload in Alzheimer’s Disease (AD) pathology has been investigated in previous years, but mechanisms underlying overload remain unclear. Ferritin is an iron storage and transport protein that has been associated with inflammation and neurodegenerative disease. OBJECTIVE The objective of this study was to evaluate if serum ferritin levels in AD subjects are significantly higher than serum ferritin levels among a healthy control. METHODS A systematic literature search of the PubMed database yielded fifty publications, culminating in two studies that were used in statistical analysis. RESULTS Our results showed that pooled serum ferritin levels were significantly higher in AD patients than in healthy controls [SMD: 1.06, 95 % CI: (0.68, 1.43), z = 5.53, p ≈ 0.00]. CONCLUSIONS Findings from this study suggest that serum ferritin may be a potent blood biomarker for AD. Research must be conducted to further evaluate the role of serum ferritin as a neurotoxic, neuroprotective, or an indicator molecule in AD pathology. We propose that increased serum ferritin levels in AD may contribute to neuroinflammation and iron overload in neuroglia.


2013 ◽  
Vol 18 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Robert J. Barth

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.


2019 ◽  
Author(s):  
Bettina Moltrecht ◽  
Jessica Deighton ◽  
Praveetha Patalay ◽  
Julian Childs

Background: Research investigating the role of emotion regulation (ER) in the development and treatment of psychopathology has increased in recent years. Evidence suggests that an increased focus on ER in treatment can improve existing interventions. Most ER research has neglected young people, therefore the present meta-analysis summarizes the evidence for existing psychosocial intervention and their effectiveness to improve ER in youth. Methods: A systematic review and meta-analysis was conducted according to the PRISMA guidelines. Twenty-one randomized-control-trials (RCTs) assessed changes in ER following a psychological intervention in youth exhibiting various psychopathological symptoms.Results: We found moderate effect sizes for current interventions to decrease emotion dysregulation in youth (g=-.46) and small effect sizes to improve emotion regulation (g=0.36). Significant differences between studies including intervention components, ER measures and populations studied resulted in large heterogeneity. Conclusion: This is the first meta-analysis that summarizes the effectiveness for existing interventions to improve ER in youth. The results suggest that interventions can enhance ER in youth, and that these improvements correlate with improvements in psychopathology. More RCTs including larger sample sizes, different age groups and psychopathologies are needed to increase our understanding of what works for who and when.


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