Comparison of a Comprehensive Set of Fibrinolytic Markers With C-Reactive Protein and Erythrocyte Sedimentation Rate for the Diagnosis of Periprosthetic Joint Infection

Recommendation: Whenever a periprosthetic joint infection (PJI) of a total ankle arthroplasty (TAA) is clinically possible or suspected, especially when elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) levels exist, and in correspondence to the literature on PJI in total hip and knee arthroplasties, joint aspiration is indicated. Level of Evidence: Consensus. Delegate Vote: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

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The Effect of Uncomplicated Knee Arthroscopy on C-reactive Protein and Erythrocyte Sedimentation Rate

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.6011 ◽

2021 ◽

Vol 9 (A) ◽

pp. 299-302

Author(s):

Andrew Hannah ◽

Graeme Ethan Hancock ◽

James Edward Stoddard ◽

Paul Mark Sutton

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Knee Arthroscopy ◽

Joint Infection ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Ethical Approval ◽

Arthroscopic Knee ◽

Operative Recovery

BACKGROUND: Anticipated changes in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) following uncomplicated knee arthroscopy have not previously been described. AIM: We aim to identify these values to aid the management of patients who re-present with a suspicion of infection. MATERIALS AND METHODS: Patients between 18 and 50 years undergoing day-case arthroscopic knee surgery under the care of the senior authors were recruited. Patients undergoing any bony intervention and those with a known inflammatory arthropathy were excluded from the study. Ethical approval was granted and patients consented to the study. ESR and CRP measurements were performed immediately prior to surgery, then at 1, 7, and 14 days postoperatively. RESULTS: A total of 29 patients consented to the study. A full set of results were achieved for 17 patients. There was a significant increase in CRP on day 1 and day 7 following knee arthroscopy with a mean increase of 4.55 mg/L (P = 0.003) on day 1 and 1.78 mg/L (P = 0.026) on day 7. ESR did not change significantly at any of the measured points. The maximum value for CRP was 16 mg/L on day 1 and 11.5 mg/L on day 7. All CRP measurements had returned to baseline (<5 mg/L) by 14 days. DISCUSSION AND CONCLUSION: Our study suggests that CRP measurement is a useful tool in the investigation of possible joint infection following simple knee arthroscopy. Continued elevation of CRP beyond 14 days or any significant elevation is not usual and suggests an abnormal post-operative recovery, which should prompt further investigation.

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A Comparative Biochemical Evaluation of Serum C- Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) in Healthy Individuals and Patients Having Odontogenic Infections

International Journal of Scientific Research ◽

10.15373/22778179/dec2013/142 ◽

2012 ◽

Vol 2 (12) ◽

pp. 460-461

Author(s):

Dr Jayprasad N Shetty ◽

◽

Dr Pratik D Shah

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Healthy Individuals ◽

C Reactive Protein ◽

Odontogenic Infections ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Biochemical Evaluation

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Diagnostic value of procalcitonin, erythrocyte sedimentation rate (ESR), quantitative C-reactive protein (CRP) and clinical findings associated with osteomyelitis in patients with diabetic foot

Human Antibodies ◽

10.3233/hab-210439 ◽

2021 ◽

pp. 1-7

Author(s):

Zahra Soleimani ◽

Fatemeh Amighi ◽

Zarichehr Vakili ◽

Mansooreh Momen-Heravi ◽

Seyyed Alireza Moravveji

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Roc Curve ◽

Diabetic Foot ◽

Diagnostic Value ◽

Clinical Findings ◽

Diabetic Patients ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation

BACKGROUND: The diagnosis of osteomyelitis is a key step of diabetic foot management. Procalcitonin (PCT) is a novel infection marker. This study aimed to investigate the diagnostic value of procalcitonin and other conventional infection markers and clinical findings in diagnosis of osteomyelitis in diabetic foot patients. METHODS AND MATERIALS: This diagnostic value study was carried out on ninety patients with diabetic infected foot ulcers admitted in Kashan Beheshti Hospital, 2016. After obtaining consent, 10 cc blood sample was taken for measuring serum PCT, CBC, ESR, CRP and FBS. Clinical characteristics of the wounds were noted. Magnetic resonance imaging of the foot was performed in all patients to diagnose osteomyelitis. All statistical analyses were done with the use of SPSS-16. RESULTS: PCT levels were 0.13 ± 0.02 ng/mili patients with osteomyelitis (n= 45) and 0.04 ± 0.02 ng/ml in patients without osteomyelitis (n= 45). PCT, Erythrocyte sedimentation rate and C-reactive protein was found significantly higher in patients with osteomyelitis (p< 0.001). The ROC curve was calculated for PCT. The area under the ROC curve for infection identification was 1 (p< 0.001). The best cut-off value for PCT was 0.085 ng/ml. Sensitivity, specificity, and positive and negative predictive values were 100%, 97.8%,97.8% and 100%, respectively. CONCLUSION: In this group of patients, PCT was useful to discriminate patients with bone infection. Also, Erythrocyte sedimentation rate and C-reactive protein can be used as a marker of osteomyelitis in diabetic patients.

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