scholarly journals Change of cardiovascular risk associated serologic biomarkers after gastric bypass: A comparison of diabetic and non-diabetic Asian patients

Author(s):  
Jih-Hua Wei ◽  
Ming-Hsien Lee ◽  
Wei-Jei Lee ◽  
Shu-Chun Chen ◽  
Owaid M. Almalki ◽  
...  
2010 ◽  
Vol 163 (5) ◽  
pp. 735-745 ◽  
Author(s):  
D Hofsø ◽  
N Nordstrand ◽  
L K Johnson ◽  
T I Karlsen ◽  
H Hager ◽  
...  

ObjectiveWeight reduction improves several obesity-related health conditions. We aimed to compare the effect of bariatric surgery and comprehensive lifestyle intervention on type 2 diabetes and obesity-related cardiovascular risk factors.DesignOne-year controlled clinical trial (ClinicalTrials.gov identifier NCT00273104).MethodsMorbidly obese subjects (19–66 years, mean (s.d.) body mass index 45.1 kg/m2(5.6), 103 women) were treated with either Roux-en-Y gastric bypass surgery (n=80) or intensive lifestyle intervention at a rehabilitation centre (n=66). The dropout rate within both groups was 5%.ResultsAmong the 76 completers in the surgery group and the 63 completers in the lifestyle group, mean (s.d.) 1-year weight loss was 30% (8) and 8% (9) respectively. Beneficial effects on glucose metabolism, blood pressure, lipids and low-grade inflammation were observed in both groups. Remission rates of type 2 diabetes and hypertension were significantly higher in the surgery group than the lifestyle intervention group; 70 vs 33%,P=0.027, and 49 vs 23%,P=0.016. The improvements in glycaemic control and blood pressure were mediated by weight reduction. The surgery group experienced a significantly greater reduction in the prevalence of metabolic syndrome, albuminuria and electrocardiographic left ventricular hypertrophy than the lifestyle group. Gastrointestinal symptoms and symptomatic postprandial hypoglycaemia developed more frequently after gastric bypass surgery than after lifestyle intervention. There were no deaths.ConclusionsType 2 diabetes and obesity-related cardiovascular risk factors were improved after both treatment strategies. However, the improvements were greatest in those patients treated with gastric bypass surgery.


2018 ◽  
Vol 47 (4) ◽  
pp. 501-506 ◽  
Author(s):  
Soo-Kyung Cho ◽  
Dam Kim ◽  
Soyoung Won ◽  
Jiyoung Lee ◽  
ByeongJu Park ◽  
...  

2011 ◽  
Vol 21 (5) ◽  
pp. 569-573 ◽  
Author(s):  
Simara P. Donadelli ◽  
Wilson Salgado ◽  
Julio S. Marchini ◽  
Andre Schmidt ◽  
Cristiana A. F. Amato ◽  
...  

2014 ◽  
Vol 92 (1) ◽  
pp. 16-22
Author(s):  
Ricard Corcelles ◽  
Josep Vidal ◽  
Salvadora Delgado ◽  
Ainitze Ibarzabal ◽  
Raquel Bravo ◽  
...  

2014 ◽  
Vol 259 (4) ◽  
pp. 694-699 ◽  
Author(s):  
Marco Raffaelli ◽  
Caterina Guidone ◽  
Cosimo Callari ◽  
Amerigo Iaconelli ◽  
Rocco Bellantone ◽  
...  

2021 ◽  
Author(s):  
FLAVIANA FREITAS PEDRON ◽  
Glauco da Costa Alvarez ◽  
Luciana Dapieve Patias ◽  
Ana Cristina de Assunção Machado ◽  
Lidiany Oliveira de Lima ◽  
...  

Abstract Overweightness is related to a high incidence of dyslipidemia, being considered a risk factor for cardiovascular diseases.Objective: Analysis of the effect of weight loss in reducing type 2 diabetes mellitus and cardiovascular risk 2 years after Roux-en-Y gastric bypass.Methods: A retrospective study with patients who underwent Roux-en-Y gastric bypass involving accessing the database of an Obesity Surgery Clinic from March 2018 to March 2019. Male and female patients, aged 18 and over, who underwent bariatric surgery from March 2014 to March 2016 were analyzed. The following data were obtained from the medical records of patients: body weight, height, age, sex, glucose and glycated hemoglobin (HbA1C) after 24 months of surgery.Results: In total, 351 patients were studied, 80.9% of whom were female. There was a reduction in weight and in the concentrations of all biochemical parameters, except HDLc, along with a decrease in the frequency of dyslipidemia and cardiovascular risk 24 months after surgery. When comparing variations between 6 and 12 months, only group 1 reduced Hb1Ac and decreased CVR. There was a significant reduction in the level of glucose in group 1 (p = 0.036) at T4 (18 months) and T5 (24 months).Conclusion: The positive impact determined by bariatric surgery on weight loss was shown to be effective in improving the dyslipidemic profile, reducing morbidities associated with obesity and, consequently, reducing CVR after 24 months.


2017 ◽  
Vol 28 (3) ◽  
pp. 805-811 ◽  
Author(s):  
Daniel Gero ◽  
Lucie Favre ◽  
Pierre Allemann ◽  
Pierre Fournier ◽  
Nicolas Demartines ◽  
...  

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