Genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors: Results from the IMMIDIET study

2009 ◽  
Vol 207 (1) ◽  
pp. 284-290 ◽  
Author(s):  
Maria Carmela Latella ◽  
Augusto Di Castelnuovo ◽  
Michel de Lorgeril ◽  
Jozef Arnout ◽  
Francesco P. Cappuccio ◽  
...  
2006 ◽  
Vol 95 (01) ◽  
pp. 134-141 ◽  
Author(s):  
Barbara Thorand ◽  
Jens Baumert ◽  
Angela Döring ◽  
Andrea Schneider ◽  
Lloyd Chambless ◽  
...  

SummaryEndothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases and diabetes mellitus. However, the causes underlying endothelial dysfunction are not fully understood. Therefore, the aim of the present study was to investigate associations of cardiovascular risk factors with soluble adhesion molecules (sE-Selectin, sICAM-1), soluble thrombomodulin (sTM) and von Willebrand factor (vWF) as markers of endothelial dysfunction. The study population consisted of a subcohort of 2,168 men and women aged 35 to 74 years randomly drawn from three cross-sectional population-based MONICA/ KORA Augsburg surveys conducted between 1984 and 1995. In multivariable linear regression analysis, current smoking, high (versus moderate) alcohol consumption, ratio of total cholesterol/HDL-cholesterol (TC/HDL-C) and C-reactive protein (CRP) were significantly associated with elevated levels of sEselectin and sICAM-1. Increased levels of sE-selectin were also found in subjects with actual hypertension, high body mass index and prevalent diabetes mellitus. In addition, low physical activity and no (versus moderate) alcohol consumption were significantly associated with elevated concentrations of sICAM-1. Levels of sTM were higher in subjects with actual hypertension, no or high amounts of alcohol intake and a high ratio of TC/ HDL-C, but were lower in subjects witha history of myocardial infarction. VWF was significantly associated with CRP only. In conclusion, sE-selectin and sICAM-1 are more strongly associated with traditional cardiovascular risk factors than sTM and vWF.


2020 ◽  
Vol 9 (10) ◽  
pp. 5242
Author(s):  
Umesh Kapil ◽  
Aakriti Gupta ◽  
Ravi Belwal ◽  
Lakshmy Ramakrishnan ◽  
Preetika Khenduja

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Mohamed Ali ◽  
Imaduddin Mirza ◽  
Chandra Hassan ◽  
Mario Masrur ◽  
Francesco Bianco ◽  
...  

10.2196/18567 ◽  
2020 ◽  
Vol 4 (11) ◽  
pp. e18567
Author(s):  
Williams Bell Ngan ◽  
Lawrence Essama Eno Belinga ◽  
Alain Serges Patrick Essam Nlo'o ◽  
Frederic Roche ◽  
Luc Goethals ◽  
...  

Background Noncommunicable diseases (NCDs) are the leading causes of death worldwide. They were responsible for 40 million of the 57 million deaths recorded worldwide in 2016. In Cameroon, epidemiological studies have been devoted to NCDs and their risk factors. However, none provides specific information on their extent or the distribution of their risk factors within the Cameroonian defense forces. Objective The objective of our study was to assess the cardiovascular risk of a Cameroonian military population compared with that of its neighboring civilian population. Methods We conducted a cross-sectional study that involved subjects aged 18 to 58 years, recruited from October 2017 to November 2018 at the Fifth Military Sector Health Center in Ngaoundéré, Cameroon. Data collection and assessment were done according to the World Health Organization (WHO)’s STEPS manual for surveillance of risk factors for chronic NCDs and the Alcohol Use Disorders Identification Test. Five cardiovascular risk factors were assessed: smoking, harmful alcohol consumption, obesity/overweight, hypertension, and diabetes. The risk was considered high in subjects with 3 or more of the factors. Univariate analysis and multivariate logistic regression were carried out according to their indications. Results Our study sample of 566 participants included 295 soldiers and 271 civilians of the same age group (median age 32 years versus 33 years, respectively; P=.57). The military sample consisted of 31 officers and 264 noncommissioned officers (NCOs). Soldiers were more exposed to behavioral risk factors than civilians, with a prevalence of smoking of 13.9% versus 4.4% (P<.001) and excessive alcohol consumption of 61.7% versus 14.8% (P<.001). They also presented with a higher cardiovascular risk than civilians (odds ratio 2.7, 95% CI 1.50-4.81; P<.001), and among the military participants, the cardiovascular risk was higher for officers than for NCOs (51.6% versus 14.0%, respectively; P<.001). Conclusions Cameroonian soldiers are particularly exposed to cardiovascular behavioral risk factors and consequently are at higher risk of NCDs. Trial Registration ClinicalTrials.gov NCT04315441; https://clinicaltrials.gov/ct2/show/NCT04315441


BMJ ◽  
1992 ◽  
Vol 304 (6819) ◽  
pp. 80-83 ◽  
Author(s):  
G. Razay ◽  
K. W. Heaton ◽  
C. H. Bolton ◽  
A. O. Hughes

2004 ◽  
Vol 5 (1) ◽  
pp. 117
Author(s):  
R. Fabregate ◽  
J. Marquez ◽  
E. Bernal ◽  
M. Calbacho ◽  
A. Bajo ◽  
...  

2009 ◽  
Vol 66 (6) ◽  
pp. 453-458 ◽  
Author(s):  
Dusica Stojanovic ◽  
Aleksandar Visnjic ◽  
Vladimir Mitrovic ◽  
Miodrag Stojanovic

Background/Aim. Cardiovascular diseases are a leading cause of death in the majority of developed, as well as in many developing countries. The aim of this study was to determine cardiovascular risk factors in student population and to suggest possible measures for prevention. Methods. The study was carried out during 2007-2008 at the School of Medicine, University of Nis. It included 824 students in their final year (220 males, 604 females). Results. There was no significant difference in prevalence of hypertension among the male (1.81%) and female students (0%). The prevalence of obesity (Body Mass Index - BMI > 30 kg/m2) was significantly higher (p < 0.001) in the male (7.27%) than in the female population (1.32%). Abdominal obesity was also more frequently encountered (p < 0.01) in the male (9.09%) than in female population (1.32%). Every fourth student smoked cigarettes with no significant difference between the male and female students. Alcohol consumption was a significantly higher problem (p < 0.001) in the male population (18.18%) than in the female one (2.65%). Physical inactivity was more often found (p < 0.001) in the female students (65.56%), than in male ones (36.36%). By the bivariate correlation of cardiovascular risk factors, it was determined that in the male student population systolic blood pressure correlated significantly with diastolic blood pressure, BMI and waist size, whereas age correlated with sistolic blood pressure, waist size and smoking. In the female students sistolic blood pressure correlated with diastolic blood pressure, BMI and waist size; diastolic blood pressure correlated with BMI and physical inactivity; cigarette smoking correlated with alcohol consumption and age. Conclusion. Cardiovascular risk factors are present in the final-year students of the School of Medicine, University of Nis. It is necessary to insist on decreasing obesity prevalence, cigarette and alcohol consumption, and on increasing physical activity of students in order to prevent cardiovascular diseases.


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