Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors

Introduction. The presence of aortic arch calcification (AoAC) and cardiomegaly on chest radiography has been demonstrated as important risk factors for cardiovascular mortality in patients with chronic kidney disease (CKD). However, the interrelationship among AoAC, cardiomegaly, and renal function progression remains unclear. The aim of this study is to assess whether AoAC and cardiomegaly are independently associated with the renal function progression in patients with stages 3–5 CKD.Methods. We retrospectively determined AoAC and cardiomegaly by chest X-ray in 237 patients, followed up for at least three years without entering dialysis and classified into 4 groups according to the presence or absence of AoAC and cardiomegaly. The change in renal function was measured by the slope of estimated glomerular filtration rate (eGFR).Results. Of the 237 patients, the rate of eGFR decline was significantly higher in the group with coexistence of AoAC and cardiomegaly than any other groups. Baseline AoAC and proteinuria were independently associated with eGFR decline. AoAC were independently determined by age, eGFR slope, and cardiomegaly.Conclusions. The coexistence of AoAC and cardiomegaly is associated with faster eGFR decline. AoAC is an independent determinant of renal outcomes in patients with CKD stages 3–5.

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Aortic arch calcification with pericardial fat mass detected on a single chest X-ray image is closely associated with the predictive variables of future cardiovascular disease

Heart and Vessels ◽

10.1007/s00380-021-01948-2 ◽

2021 ◽

Author(s):

Kentaro Watanabe ◽

Yurika Hada ◽

Kota Ishii ◽

Kyoko Nagaoka ◽

Kaoru Takase ◽

...

Keyword(s):

Cardiovascular Disease ◽

Aortic Arch ◽

Fat Mass ◽

Pericardial Fat ◽

X Ray ◽

Predictive Variables ◽

Chest X Ray ◽

Aortic Arch Calcification

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THE PREDICTIVE VALUE OF AORTIC ARCH CALCIFICATION ON CHEST X-RAY FOR CARDIOVASCULAR EVENTS IN COMPARISON WITH THE CORONARY ARTERY CALCIUM SCORE AND THE FRAMINGHAM RISK SCORE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(17)35200-2 ◽

2017 ◽

Vol 69 (11) ◽

pp. 1811

Author(s):

Hyung Oh Kim ◽

Weon Kim ◽

Jong-Shin Woo ◽

Kwon Sam Kim ◽

Woo-Shik Kim ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Calcium ◽

Cardiovascular Events ◽

Framingham Risk Score ◽

Coronary Artery Calcium Score ◽

Calcium Score ◽

X Ray ◽

Framingham Risk ◽

Chest X Ray ◽

Aortic Arch Calcification

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Aortic Arch Calcification and Bone-Associated Molecules in Peritoneal Dialysis Patients

Blood Purification ◽

10.1159/000496657 ◽

2019 ◽

Vol 47 (Suppl. 2) ◽

pp. 81-87

Author(s):

Misao Tsukada ◽

Naoko Miwa ◽

Norio Hanafusa ◽

Nobue Tanaka ◽

Ken Tsuchiya ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Aortic Arch ◽

Pulse Wave ◽

Fibroblast Growth Factor 23 ◽

Fatal Complication ◽

X Ray ◽

Plain Chest ◽

Chest X Ray ◽

Aortic Arch Calcification

Background/Aims: Aortic arch calcification (AoAC) is a fatal complication in dialysis. AoAC progression-related molecules in continuous ambulatory peritoneal dialysis (CAPD) remain unclear. Methods: AoAC was estimated using plain chest radiography scoring (AoACS) in 30 CAPD patients (age 49.3 ± 13.4 years). AoAC progression was defined as increased AoACS on follow-up chest X-ray at the end of the study (progressors). Fibroblast growth factor-23 and osteoprotegerin (OPG) were measured. Results: Median follow-up was 38.5 months. Progressors were older, had shorter PD vintage, higher body mass index, and higher serum OPG levels (255.6 ± 109.2 pg/mL) than nonprogressors (183.4 ± 68.2 pg/mL; p = 0.0400). Progressors also showed higher pulse pressure (62.4 ± 20.0 mm Hg) and pulse wave velocity (1,909.9 ± 310.6 cm/s) than nonprogressors (48.5 ± 13.6 mm Hg; p = 0.0030 and 1,390.1 ± 252.8 cm/s; p = 0.0005, respectively). Conclusion: AoAC progression was associated with increased aortic stiffness. OPG may be associated with AoAC progression in CAPD.

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Aortic Arch Calcification Detectable on Chest X-ray Films is Associated with Plasma Diacron-reactive Oxygen Metabolites in Patients with Type 2 Diabetes but without Cardiovascular Disease

Journal of Nippon Medical School ◽

10.1272/jnms.80.410 ◽

2013 ◽

Vol 80 (6) ◽

pp. 410-419 ◽

Cited By ~ 3

Author(s):

Kentaro Watanabe ◽

Makoto Ohara ◽

Tatsuya Suzuki ◽

Motoshi Ouchi ◽

Kazunari Suzuki ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Aortic Arch ◽

Reactive Oxygen ◽

Reactive Oxygen Metabolites ◽

X Ray ◽

Chest X Ray ◽

Oxygen Metabolites ◽

Aortic Arch Calcification

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Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension

Medical Principles and Practice ◽

10.1159/000495786 ◽

2018 ◽

Vol 28 (2) ◽

pp. 133-140 ◽

Cited By ~ 1

Author(s):

Adem Adar ◽

Orhan Onalan ◽

Hakan Keles ◽

Fahri Cakan ◽

Ugur Kokturk

Keyword(s):

Regression Analysis ◽

Aortic Arch ◽

Doppler Ultrasonography ◽

Linear Regression Analysis ◽

Resistive Index ◽

Left Ventricular ◽

Renal Resistive Index ◽

X Ray ◽

Chest X Ray ◽

Aortic Arch Calcification

Objective: Aortic arch calcification (AAC) is a surrogate marker for arterial stiffness and hypertension-related vascular damage. Renal resistive index (RRI), a renal Doppler ultrasonography parameter, is used to assess renal hemodynamics. In this study, we aimed to evaluate the relationship between RRI and AAC in patients with hypertension. Methods: Patients with hypertension underwent a chest X-ray and re nal Doppler ultrasonography. They were divided into two groups according to RRI (group 1: RRI ≥0.70; group 2: RRI < 0.70). Two examiners, blinded to the findings of RRI, reviewed the AAC in these patients. The kappa value was detected to be 0.781 and a p value < 0.001 was considered significant. Results: The study included 289 hypertensive patients (mean age 63.87 ± 11.38 years). In 53.6% (n = 155) of the study subjects, RRI was observed to be ≥0.70. Patients with RRI ≥70 were older and had more prevalent AAC as well as left ventricular hypertrophy. A multiple linear regression analysis was carried out to test whether presence of AAC significantly predicted RRI. The results of the regression analysis indicated that presence of AAC significantly predicted RRI (β = 0.053; p < 0.001). Conclusions: A strong and independent relationship was found between AAC on chest X-ray and RRI in patients with hypertension.

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