Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals

2011 ◽  
Vol 219 (2) ◽  
pp. 704-708 ◽  
Author(s):  
Meei-Maan Wu ◽  
Hung-Yi Chiou ◽  
Chi-Ling Chen ◽  
Ling-I Hsu ◽  
Li-Ming Lien ◽  
...  
2014 ◽  
Vol 64 (5) ◽  
pp. 472-481 ◽  
Author(s):  
Duck-chul Lee ◽  
Russell R. Pate ◽  
Carl J. Lavie ◽  
Xuemei Sui ◽  
Timothy S. Church ◽  
...  

Author(s):  
Serkan Asil ◽  
Ender Murat ◽  
Hatice Taşkan ◽  
Veysel Özgür Barış ◽  
Suat Görmel ◽  
...  

Introduction: The most important way to reduce CVD-related mortality is to apply appropriate treatment according to the risk status of the patients. For this purpose, the SCORE risk model is used in Europe. In addition to these risk models, some anthropometric measurements are known to be associated with CVD risk and risk factors. Objectives: This study aimed to investigate the association of these anthropometric measurements, especially neck circumference (NC), with the SCORE risk chart. Methods: This was planned as a cross-sectional study. The study population were classified according to their SCORE risk values. The relationship of NC and other anthropometric measurements with the total cardiovascular risk indicated by the SCORE risk was investigated. Results: A total of 232 patients were included in the study. The patients participating in the study were analysed in four groups according to the SCORE ten-year total cardiovascular mortality risk. As a result, the NC was statistically significantly lower among the SCORE low and moderate risk group than all other SCORE risk groups (low-high and very high 36(3)–38(4) (IQR) p: 0.026, 36(3)–39(4) (IQR) p < 0.001, 36(3)–40(4) (IQR) p < 0.001), (moderate-high and very high 38(4) vs. 39(4) (IQR) p: 0.02, 38(4) vs. 40(4) (IQR) p < 0.001, 39(4) vs. 40(4) (IQR) p > 0.05). NC was found to have the strongest correlation with SCORE than the other anthropometric measurements. Conclusions: Neck circumference correlates strongly with the SCORE risk model which shows the ten-year cardiovascular mortality risk and can be used in clinical practice to predict CVD risk.


JAMA ◽  
2005 ◽  
Vol 293 (14) ◽  
pp. 1737 ◽  
Author(s):  
Michael G. Shlipak ◽  
Linda F. Fried ◽  
Mary Cushman ◽  
Teri A. Manolio ◽  
Do Peterson ◽  
...  

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0143839 ◽  
Author(s):  
Abdonas Tamosiunas ◽  
Ricardas Radisauskas ◽  
Jurate Klumbiene ◽  
Gailute Bernotiene ◽  
Janina Petkeviciene ◽  
...  

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 181 ◽  
Author(s):  
Heather A. Drummond ◽  
Zachary L. Mitchell ◽  
Nader G. Abraham ◽  
David E. Stec

Heme oxygenase (HO) plays an important role in the cardiovascular system. It is involved in many physiological and pathophysiological processes in all organs of the cardiovascular system. From the regulation of blood pressure and blood flow to the adaptive response to end-organ injury, HO plays a critical role in the ability of the cardiovascular system to respond and adapt to changes in homeostasis. There have been great advances in our understanding of the role of HO in the regulation of blood pressure and target organ injury in the last decade. Results from these studies demonstrate that targeting of the HO system could provide novel therapeutic opportunities for the treatment of several cardiovascular and renal diseases. The goal of this review is to highlight the important role of HO in the regulation of cardiovascular and renal function and protection from disease and to highlight areas in which targeting of the HO system needs to be translated to help benefit patient populations.


2020 ◽  
Vol 229 ◽  
pp. 171
Author(s):  
Noraidatulakma Abdullah ◽  
Nor Azian Abdul Murad ◽  
Raihannah Othman ◽  
Azwa Shazwani Kamalul Arifin ◽  
Mohd Raziff Alias ◽  
...  

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