Single-cell analysis uncovers osteoblast factor GDF10 as mediator of vascular smooth muscle cell phenotypic modulation associated with plaque rupture in human carotid artery disease

2021 ◽  
Vol 331 ◽  
pp. e23
Author(s):  
K.T. Miteva ◽  
K.J. Brandt ◽  
F. Burger ◽  
D. Baptista ◽  
F. Montecucco ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Carotid Artery ◽  
Smooth Muscle Cell ◽  
Single Cell Analysis ◽  
Plaque Rupture ◽  
Carotid Artery Disease ◽  
Cell Analysis ◽  
Phenotypic Modulation ◽  
Artery Disease ◽  
Human Carotid

scholarly journals Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

2019 ◽  
Vol 25 (8) ◽  
pp. 1280-1289 ◽  
Author(s):  
Robert C. Wirka ◽  
Dhananjay Wagh ◽  
David T. Paik ◽  
Milos Pjanic ◽  
Trieu Nguyen ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Single Cell ◽  
Muscle Cell ◽  
Disease Gene ◽  
Single Cell Analysis ◽  
Cell Analysis ◽  
Phenotypic Modulation

scholarly journals Imaging of nonatheromatous carotid artery disease

2021 ◽  
Vol 5 (1) ◽  
pp. 2514183X2110145
Author(s):  
Daniel Montes ◽  
Javier M Romero
Keyword(s):  
Carotid Artery ◽  
Plaque Rupture ◽  
Carotid Artery Disease ◽  
Imaging Features ◽  
Imaging Evaluation ◽  
Inflammatory Conditions ◽  
Risk Patients ◽  
Artery Disease ◽  
Low Prevalence ◽  
Atherosclerotic Plaque Rupture

Imaging diagnosis of nonatheromatous carotid artery disease is challenging due to its low prevalence in contrast to that of atheromatous disease. Congenital anomalies are frequently discovered incidentally, as the chronicity of these conditions allows for compensatory flow development. The inflammatory conditions typically present with nonspecific courses, and a high clinical suspicion along with timely imaging evaluation can guide the diagnosis. Carotid dissection is the result of a partial disruption of the arterial wall and can be seen in previously healthy patients, in patients with underlying noninflammatory arteriopathies or trauma. Traumatic injuries to the carotid artery may occur under many different conditions and mechanisms and timely recognition of high-risk patients improves patient outcomes. Although free-floating thrombi (FFT) formation is typically seen with atherosclerotic plaque rupture, different conditions may also predispose to FFT. In this review article, we study the different imaging features of nonatheromatous carotid artery disease using ultrasonography, computed tomography angiography, magnetic resonance angiography, and digital subtraction angiogram.

scholarly journals Quantitative ultrasound pulsation study in human carotid artery disease.

1988 ◽  
Vol 8 (6) ◽  
pp. 778-781 ◽  
Author(s):  
J D Barth ◽  
D H Blankenhorn ◽  
E Wickham ◽  
J Y Lai ◽  
H P Chin ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Quantitative Ultrasound ◽  
Carotid Artery Disease ◽  
Artery Disease ◽  
Human Carotid

scholarly journals Distinct Characteristics between Perivascular and Subcutaneous Adipose Derived Stem Cells

2021 ◽  
Author(s):  
Yao Xie ◽  
Yongli Ji ◽  
Yunrui Lu ◽  
Yuankun Ma ◽  
Hui Ni ◽  
...  
Keyword(s):  
Stem Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Single Cell ◽  
Vascular Remodeling ◽  
Single Cell Analysis ◽  
Adipose Derived Stem Cells ◽  
Cell Analysis ◽  
Cell Fates ◽  
Subcutaneous Adipose

Adipose derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention due to their unique location. The heterogeneity of subcutaneous (SUB-) and abdominal ADSCs were well addressed, but PV-ADSCs’ heterogeneity hasn’t been investigated. In the present study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs respectively regarding their subpopulations, functions, and cell fates. We uncovered 4 subpopulations of PV-ADSCs including <i>Dpp4+</i>, <i>Col4a2+</i>/<i>Icam1+</i>, <i>Clec11a+</i>/<i>Cpe+</i> and <i>Sult1e1+</i> cells, among which <a></a><a><i>Clec11a</i>+ subpopulation</a> potentially participated in and regulated the PV-ADSCs differentiation towards a smooth muscle cell (SMC) phenotype. The present study revealed the <a></a><a>distinct characteristics </a>between PV-ADSCs and SUB-ADSCs.

scholarly journals Distinct Characteristics between Perivascular and Subcutaneous Adipose Derived Stem Cells

2021 ◽  
Author(s):  
Yao Xie ◽  
Yongli Ji ◽  
Yunrui Lu ◽  
Yuankun Ma ◽  
Hui Ni ◽  
...  
Keyword(s):  
Stem Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Single Cell ◽  
Vascular Remodeling ◽  
Single Cell Analysis ◽  
Adipose Derived Stem Cells ◽  
Cell Analysis ◽  
Cell Fates ◽  
Subcutaneous Adipose

Adipose derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention due to their unique location. The heterogeneity of subcutaneous (SUB-) and abdominal ADSCs were well addressed, but PV-ADSCs’ heterogeneity hasn’t been investigated. In the present study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs respectively regarding their subpopulations, functions, and cell fates. We uncovered 4 subpopulations of PV-ADSCs including <i>Dpp4+</i>, <i>Col4a2+</i>/<i>Icam1+</i>, <i>Clec11a+</i>/<i>Cpe+</i> and <i>Sult1e1+</i> cells, among which <a></a><a><i>Clec11a</i>+ subpopulation</a> potentially participated in and regulated the PV-ADSCs differentiation towards a smooth muscle cell (SMC) phenotype. The present study revealed the <a></a><a>distinct characteristics </a>between PV-ADSCs and SUB-ADSCs.

Convulsive Syncopes in a Patient with Carotid Artery Disease

2004 ◽  
Vol 35 (03) ◽  
Author(s):  
C Terborg ◽  
G Heide ◽  
H Axer ◽  
F Joachimski ◽  
S Köhler ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Disease ◽  
Artery Disease
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