Valproic Acid Prevents Brain Injury in a Canine Model of Hypothermic Circulatory Arrest: A Promising New Approach to Neuroprotection During Cardiac Surgery

2006 ◽  
Vol 81 (6) ◽  
pp. 2235-2242 ◽  
Author(s):  
Jason A. Williams ◽  
Christopher J. Barreiro ◽  
Lois U. Nwakanma ◽  
Mary S. Lange ◽  
Lisa E. Kratz ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cardiac Surgery ◽  
Brain Injury ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest ◽  
New Approach

scholarly journals Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest

2011 ◽  
Vol 142 (4) ◽  
pp. 902-910.e1 ◽  
Author(s):  
George J. Arnaoutakis ◽  
Timothy J. George ◽  
Kevin K. Wang ◽  
Mary Ann Wilson ◽  
Jeremiah G. Allen ◽  
...  
Keyword(s):  
Brain Injury ◽  
Circulatory Arrest ◽  
Serum Levels ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest ◽  
Carboxyl Terminal

scholarly journals Alpha II-Spectrin Breakdown Products Serve as Novel Markers of Brain Injury Severity in a Canine Model of Hypothermic Circulatory Arrest

2009 ◽  
Vol 88 (2) ◽  
pp. 543-550 ◽  
Author(s):  
Eric S. Weiss ◽  
Kevin K.W. Wang ◽  
Jeremiah G. Allen ◽  
Mary E. Blue ◽  
Lois U. Nwakanma ◽  
...  
Keyword(s):  
Brain Injury ◽  
Injury Severity ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest

scholarly journals Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest–Induced Brain Injury

2016 ◽  
Vol 102 (3) ◽  
pp. 743-750 ◽  
Author(s):  
Joshua C. Grimm ◽  
J. Trent Magruder ◽  
Mary A. Wilson ◽  
Mary E. Blue ◽  
Todd C. Crawford ◽  
...  
Keyword(s):  
Brain Injury ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest

Clinical neurologic and developmental studies after cardiac surgery utilizing hypothermic circulatory arrest and cardiopulmonary bypass

1993 ◽  
Vol 3 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Gil Wernovsky ◽  
Richard A. Jonas ◽  
Paul R. Hickey ◽  
Adré J. du Plessis ◽  
Jane W. Newburger
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Circulatory Arrest ◽  
Neurodevelopmental Outcome ◽  
Hypothermic Circulatory Arrest ◽  
Cerebral Injury ◽  
Profound Hypothermia ◽  
The Central Nervous System

The dramatic reduction in surgical mortality associated with repair of congenital heart anomalies in recent decades has been accompanied by a growing recognition of adverse neurologic sequels in some of the survivors. Abnormalities of the central nervous system may be a function of coexisting cerebral abnormalities or acquired events unrelated to surgical management (such as paradoxical embolus, cerebral infection, or effects of chronic cyanosis), but insults to the central nervous system appear to occur most frequently during or immediately after surgery. In particular, techniques of support used during neonatal and infant cardiac surgery—cardiopulmonary bypass, profound hypothermia and circulatory arrest—have been implicated as important causes of cerebral injury. This paper will review the effects of bypass and deep hypothermic circulatory arrest on neurodevelopmental outcome.

NMDA Receptor Antagonism for Neuroprotection in a Canine Model of Hypothermic Circulatory Arrest

2021 ◽  
Vol 260 ◽  
pp. 177-189
Author(s):  
Katherine Giuliano ◽  
Eric Etchill ◽  
Xun Zhou ◽  
Cecillia Lui ◽  
Alejandro Suarez-Pierre ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest ◽  
Receptor Antagonism
Sign in / Sign up

Export Citation Format

Share Document