Minute Ventilation-to-Carbon Dioxide Output (e/co2) Slope Is the Strongest Predictor of Respiratory Complications and Death After Pulmonary Resection

2012 ◽  
Vol 93 (6) ◽  
pp. 1802-1806 ◽  
Author(s):  
Alessandro Brunelli ◽  
Romualdo Belardinelli ◽  
Cecilia Pompili ◽  
Francesco Xiumé ◽  
Majed Refai ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Pulmonary Resection ◽  
Minute Ventilation ◽  
Respiratory Complications ◽  
Carbon Dioxide Output

Respiratory compensation point

2021 ◽  
pp. 93-96
Author(s):  
William J.M. Kinnear ◽  
James H. Hull
Keyword(s):  
Carbon Dioxide ◽  
Minute Ventilation ◽  
Cardiopulmonary Exercise Test ◽  
Compensation Point ◽  
Respiratory Compensation Point ◽  
Carbon Dioxide Output ◽  
Respiratory Compensation ◽  
Cardiopulmonary Exercise ◽  
The Subject ◽  
Maximal Effort

This chapter describes how acidaemia stimulates ventilation in the later stages of a cardiopulmonary exercise test (CPET). This happens after the anaerobic threshold, once the capacity of the blood to buffer lactic acid has been used up. The respiratory compensation point (RCP) can be identified from an increase in the slope when minute ventilation (VE) is plotted against carbon dioxide output (VCO2), or from a rise in the ventilatory equivalents for carbon dioxide (VeqCO2). The presence of a clear RCP indicates that the subject has made a fairly maximal effort during the CPET. An RCP also argues against significant lung disease, since it implies the ability to increase ventilation in response to acidaemia.

Intratest reliability and test–retest reproducibility of the oxygen uptake efficiency slope in healthy participants

2009 ◽  
Vol 16 (4) ◽  
pp. 493-498 ◽  
Author(s):  
Christophe Van Laethem ◽  
Johan De Sutter ◽  
Wim Peersman ◽  
Patrick Calders
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Uptake ◽  
Minute Ventilation ◽  
Exercise Duration ◽  
Peak Oxygen Uptake ◽  
Exercise Tests ◽  
Uptake Efficiency ◽  
Carbon Dioxide Output ◽  
Oxygen Uptake Efficiency Slope ◽  
Healthy Participants

Background The oxygen uptake efficiency slope (OUES) is a newer ventilatory exercise parameter, used in the evaluation of healthy participants and patients with cardiovascular disease. However, few data about the reliability and reproducibility of OUES are available. Our study assessed intratest reliability and test-retest reproducibility of OUES in healthy participants. Design and methods Eighteen participants (age 28 ± 6 years, BMI 22.1 ± 1.9 kg/m2, 10 men) performed two identical maximal exercise tests on a bicycle ergometer. To assess test-retest reproducibility, we performed Bland-Altman analysis and calculated the coefficient of repeatability of the main ventilatory variables. Results OUES remained stable during the second part of the exercise test. Mean values varied 2.4 ± 4.0% between OUES calculated at 70% (OUES70) and at 100% of exercise duration. Mean variation decreased to 1.4 ± 2.3% when OUES was calculated at 90% of exercise duration (OUES90). The Bland-Altman 95% limits of agreement for OUES90 were +3 and –6%, those for OUES70 were +11 and –8%. The coefficient of repeatability for OUES was 597 ml/min or 18.7% of the average value of repeated OUES measurements. These results were similar to those of peak oxygen uptake and minute ventilation/carbon dioxide output. However, the test-retest reproducibility for submaximal-derived values of OUES was lower, as we noted higher coefficients of repeatability for OUES90 and OUES70, increasing up to 27% of the average of repeated values. Conclusion OUES shows excellent intratest reliability and has a test-retest reproducibility that is similar to that of peak oxygen uptake and minute ventilation/carbon dioxide output slope. However, its reproducibility becomes higher when it is calculated from increasing levels of achieved exercise intensity.

Intercept of minute ventilation vs. carbon dioxide output relationship in chronic obstructive pulmonary disease: utility as an index of ventilatory inefficiency

2020 ◽  
Author(s):  
Haoyan Wang ◽  
Fang Lin ◽  
Shan Nie ◽  
Ranran Zhao ◽  
Min Cao ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Minute Ventilation ◽  
Airflow Limitation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lung Hyperinflation ◽  
Carbon Dioxide Output ◽  
Copd Patients

Abstract Background: Ventilatory inefficiency is known to be a contributor to exercise intolerance in chronic obstructive pulmonary disease (COPD). The intercept of the minute ventilation (V̇E) vs. carbon dioxide output (V̇CO2) plot is a key ventilator inefficiency parameter. However, its relationships with lung hyperinflation (LH) and airflow limitation are not known. This study aimed to evaluate the correlations between the V̇E/V̇CO2 intercept and LH in COPD to determine its utility as an index of functional impairment.Methods: We conducted a retrospective analysis of data from 53 COPD patients and 14 healthy controls performed incremental cardiopulmonary exercise tests and resting pulmonary function. Ventilatory inefficiency was represented by parameters reflecting the V̇E/V̇CO2 nadir and slope (linear region), and intercept of the V̇E/V̇CO2 plot. Their correlations with measures of LH and airflow limitation were evaluated.Results: Compared to the control, the slope (30.58±3.62) and intercept (4.85±1.11) higher in COPDstages1-2, leading to a higher nadir (31.47±4.47) (p<0.05). Despite an even higher intercept in COPDstages3-4 (7.16±1.41), the slope diminished with disease progression (from 30.58±3.62 in COPDstages1-2 to 28.36±4.58 in COPDstages3-4). Compared to the V̇E/V̇CO2 nadir and V̇E/V̇CO2 slope, the intercept was better correlated with peak V̇E/maximal voluntary ventilation (MVV) (r=0.489, p<0.001) and peak V̇O2/watt (r=0.354, p=0.003). The intercept was also significantly correlated with RV/TLC (r=0.588, p<0.001), IC/TLC (r=-0.574, p<0.001), peak VT/TLC (r=-0.585, p<0.001); and airflow limitation forced expiratory volume in 1s (FEV1) % predicted (r=-0.606, p<0.001) and FEV1/forced vital capacity (FVC) (r=-0.629, p<0.001).Conclusion: V̇E/V̇CO2intercept was consistently better correlated with worsening static and dynamic lung hyperinflation and airflow limitation in COPD. V̇E/V̇CO2 intercept emerged as a useful index of ventilatory inefficiency across the severity spectrum of COPD patients.

THE EFFECT OF PRIOR HIGH INTENSITY EXERCISE ON MINUTE VENTILATION AND CARBON DIOXIDE OUTPUT DURING STEADY-STATE EXCERCISE

1984 ◽  
Vol 16 (2) ◽  
pp. 179
Author(s):  
D. J. Berriman ◽  
V. J. Caiozzo ◽  
J. A. Davis ◽  
R. V. Vandagriff ◽  
C. A. Prietto ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Steady State ◽  
High Intensity ◽  
Minute Ventilation ◽  
High Intensity Exercise ◽  
Carbon Dioxide Output

scholarly journals P1.16-44 Minute Ventilation-To-Carbon Dioxide Slope is Associated with Early and Long Term Survivals Following Anatomical Pulmonary Resection

2018 ◽  
Vol 13 (10) ◽  
pp. S645 ◽  
Author(s):  
T. Miyazaki ◽  
A. Brunelli ◽  
P. Dimesh ◽  
M. Callster ◽  
K. Franks ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Pulmonary Resection ◽  
Minute Ventilation

Carbon dioxide output

2021 ◽  
pp. 63-71
Author(s):  
William J.M. Kinnear ◽  
James H. Hull
Keyword(s):  
Carbon Dioxide ◽  
Lactic Acid ◽  
Oxygen Uptake ◽  
Dead Space ◽  
Exercise Test ◽  
Minute Ventilation ◽  
Cardiopulmonary Exercise Test ◽  
Carbon Dioxide Output ◽  
Cardiopulmonary Exercise ◽  
Ventilatory Equivalent

This chapter describes how carbon dioxide is produced from metabolism and also from buffering of lactic acid. The volume of carbon dioxide exhaled (VCO2) is calculated from the concentration in exhaled gas and minute ventilation. If the lungs are less efficient than normal, with a high dead space, the amount of ventilation needed to achieve any given VCO2 is much higher. This index, known as the ventilatory equivalent for carbon dioxide, is an important prognostic marker. Early on in a cardiopulmonary exercise test (CPET), VCO2 is slightly less than the oxygen uptake (VO2). As exercise reaches its maximum, VCO2 increases more quickly when acidaemia starts to stimulate ventilation.

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