Attempt to correct abnormal signal transduction in T lymphocytes from systemic lupus erythematosus patients

2006 ◽  
Vol 5 (2) ◽  
pp. 143-144 ◽  
Author(s):  
Yuko Fujii ◽  
Koichi Fujii ◽  
Yoshiya Tanaka
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Signal Transduction ◽  
T Lymphocytes ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Abnormal Signal

scholarly journals High levels ofbcl-2 protein in circulating t lymphocytes, but not b lymphocytes, of patients with systemic lupus erythematosus

1994 ◽  
Vol 37 (10) ◽  
pp. 1423-1430 ◽  
Author(s):  
Martin Aringer ◽  
Winfried Wintersberger ◽  
Carl W. Steiner ◽  
Hans Kiener ◽  
Elisabeth Presterl ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Lymphocytes ◽  
B Lymphocytes ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Activation signal transduction by β1 integrin in T cells from patients with systemic lupus erythematosus

2007 ◽  
Vol 56 (5) ◽  
pp. 1559-1568 ◽  
Author(s):  
Shingo Nakayamada ◽  
Kazuyoshi Saito ◽  
Kazuhisa Nakano ◽  
Yoshiya Tanaka
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Signal Transduction ◽  
T Cells ◽  
Lupus Erythematosus ◽  
Β1 Integrin ◽  
Systemic Lupus

scholarly journals Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Alessia Alunno ◽  
Elena Bartoloni ◽  
Onelia Bistoni ◽  
Giuseppe Nocentini ◽  
Simona Ronchetti ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Lymphocytes ◽  
Lupus Erythematosus ◽  
Th17 Cells ◽  
Current Knowledge ◽  
Treg Cells ◽  
T Helper ◽  
Systemic Lupus ◽  
Target Organs

Pathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified. However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well established. Among T cells, IL-17 producing T helper (Th17) cells and regulatory T (Treg) cells represent an intriguing issue to be addressed in SLE pathogenesis, since an imbalance between the two subsets has been observed in the course of the disease. Treg cells appear to be impaired and therefore unable to counteract autoreactive T lymphocytes. Conversely, Th17 cells accumulate in target organs contributing to local IL-17 production and eventually tissue damage. In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent an intriguing and useful tool for SLE treatment in the next future. In this paper, the current knowledge about Treg and Th17 cells interplay in SLE will be discussed.

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