Effects of Clustered Comorbid Conditions on Walking Capacity in Patients with Peripheral Artery Disease

This is the first sham-controlled study to investigate the effects of leg heat therapy (HT) on walking performance, vascular function, and quality of life in patients with peripheral artery disease (PAD). Adherence to HT was high, and the treatment was well tolerated. Our findings revealed that HT applied with water-circulating trousers evokes a clinically meaningful increase in perceived physical function and reduces the serum concentration of the potent vasoconstrictor endothelin-1 in patients with PAD.

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Intermittent vacuum treatment with VacuMed does not improve peripheral artery disease or walking capacity in patients with intermittent claudication

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.1080/00365513.2018.1497803 ◽

2018 ◽

Vol 78 (6) ◽

pp. 456-463 ◽

Cited By ~ 2

Author(s):

Pia Afzelius ◽

Stig Molsted ◽

Lise Tarnow

Keyword(s):

Intermittent Claudication ◽

Peripheral Artery Disease ◽

Vacuum Treatment ◽

Peripheral Artery ◽

Walking Capacity ◽

Artery Disease

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Acute mitochondrial antioxidant intake improves endothelial function, antioxidant enzyme activity, and exercise tolerance in patients with peripheral artery disease

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00235.2020 ◽

2020 ◽

Vol 319 (2) ◽

pp. H456-H467 ◽

Cited By ~ 1

Author(s):

Song-Young Park ◽

Elizabeth J. Pekas ◽

Ronald J. Headid ◽

Won-Mok Son ◽

TeSean K. Wooden ◽

...

Keyword(s):

Endothelial Function ◽

Peripheral Artery Disease ◽

Oral Intake ◽

Muscle Performance ◽

Vascular Endothelial ◽

Peripheral Artery ◽

Walking Capacity ◽

Antioxidant Intake ◽

Artery Disease ◽

First Time

The results of this study reveal for the first time that acute oral intake of mitochondrial-targeted antioxidant (MitoQ, 80 mg) is effective for improving vascular endothelial function and superoxide dismutase in patients with peripheral artery disease (PAD). Acute MitoQ intake is also effective for improving maximal walking capacity and delaying the onset of claudication in patients with PAD. These findings suggest that the acute oral intake of MitoQ-mediated improvements in vascular mitochondria play a pivotal role for improving endothelial function, the redox environment, and skeletal muscle performance in PAD.

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Three times a week and five times a week walking exercise frequencies are equally effective in improving walking capacity in experimental peripheral artery disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2016.07.427 ◽

2016 ◽

Vol 252 ◽

pp. e59-e60

Author(s):

M. Pellegrin ◽

J. Lavier ◽

K. Bouzourene ◽

L. Mazzolai

Keyword(s):

Peripheral Artery Disease ◽

Peripheral Artery ◽

Walking Capacity ◽

Walking Exercise ◽

Artery Disease

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"Should I stay or should I go now?"Recovery time effect on walking capacity in symptomatic peripheral artery disease

Journal of Applied Physiology ◽

10.1152/japplphysiol.00441.2020 ◽

2021 ◽

Author(s):

Pierre-Yves de Müllenheim ◽

Laurent Rouvière ◽

Mathieu Emily ◽

Ségolène Chaudru ◽

Adrien Kaladji ◽

...

Keyword(s):

Peripheral Artery Disease ◽

Recovery Time ◽

Treadmill Walking ◽

Peripheral Artery ◽

Indirect Measure ◽

Transcutaneous Oxygen ◽

Walking Capacity ◽

Artery Disease ◽

Single Sequence ◽

Walking Time

Objective: To investigate the effect of recovery time on walking capacity (WC) throughout repeated maximal walking bouts in symptomatic lower extremity peripheral artery disease (PAD). Methods: The effect of recovery time on WC (maximal walking time) was determined in 21 PAD participants in three experimental conditions (recovery time from 0.5-9.5 min + a self-selected recovery time [SSRT]): (i) 11 repeated sequences of two treadmill walking bouts (TW-ISO); (ii) a single sequence of seven treadmill walking bouts (TW-CONS); (iii) a single sequence of seven outdoor walking bouts (OW-CONS). Exercise transcutaneous oxygen pressure changes were continuously recorded as an indirect measure of ischemia. An individual recovery time (IRT) beyond which WC did not substantially increase was determined in participants with a logarithmic fit. Results: At the group level, mixed models showed a significant effect (P<0.001) of recovery time on WC restoration. At the participant level, strong logarithmic relationships were found (median significant R2³0.78). The median SSRT corresponded to a median work-to-rest ratio >1:1 (i.e., a lower recovery time in view of the corresponding previous walking time) and was related to unrecovered ischemia and a WC restoration level of <80%. A median work-to-rest ratio of ≤1:2 allowed full recovery of ischemia and full restoration of WC. The IRT ratio was between 1:1 and 1:2 and corresponded to the start of recovery from ischemia. Conclusion: Recovery time affects the restoration level of WC during repeated maximal walking bouts in symptomatic PAD. Meaningful variations in WC restoration were related to specific levels of work-to-rest ratios.

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