Moral judgment and decision making in Huntington’s disease

Basal Ganglia ◽  
2012 ◽  
Vol 2 (3) ◽  
pp. 139-142 ◽  
Author(s):  
C.M. Eddy ◽  
H.E. Rickards
2019 ◽  
Vol 10 ◽  
Author(s):  
Giulia D’Aurizio ◽  
Simone Migliore ◽  
Giuseppe Curcio ◽  
Ferdinando Squitieri

Author(s):  
Daniel M. Bartels ◽  
Christopher W. Bauman ◽  
Fiery A. Cushman ◽  
David A. Pizarro ◽  
A. Peter McGraw

2004 ◽  
Vol 10 (2) ◽  
pp. 239-245 ◽  
Author(s):  
MEGHAN C. CAMPBELL ◽  
JULIE C. STOUT ◽  
PETER R. FINN

We examined the possible role of autonomic activity in Huntington's disease (HD) during a risky decision making task. Skin conductance responses (SCRs) of 15 HD participants and 16 healthy controls were measured while they performed a computerized version of the Simulated Gambling Task (SGT). The results replicated our previous finding of a performance decrement in HD, and showed that HD was associated with an altered pattern of SCRs during the risky decision task. Specifically, the healthy controls produced increased SCRs following selections from the disadvantageous decks and following losing selections. In contrast, the SCRs of the HD group did not differentiate between wins and losses. These findings indicate a reduced impact of loss on decision-making processes under risky conditions in HD. (JINS, 2004, 10, 239–245.)


2015 ◽  
Vol 22 (4) ◽  
pp. 426-435 ◽  
Author(s):  
Nelleke C. van Wouwe ◽  
Kristen E. Kanoff ◽  
Daniel O. Claassen ◽  
K. Richard Ridderinkhof ◽  
Peter Hedera ◽  
...  

AbstractObjectives: Huntington’s disease (HD) is a neurodegenerative disorder that produces a bias toward risky, reward-driven decisions in situations where the outcomes of decisions are uncertain and must be discovered. However, it is unclear whether HD patients show similar biases in decision-making when learning demands are minimized and prospective risks and outcomes are known explicitly. We investigated how risk decision-making strategies and adjustments are altered in HD patients when reward contingencies are explicit. Methods: HD (N=18) and healthy control (HC; N=17) participants completed a risk-taking task in which they made a series of independent choices between a low-risk/low reward and high-risk/high reward risk options. Results: Computational modeling showed that compared to HC, who showed a clear preference for low-risk compared to high-risk decisions, the HD group valued high-risks more than low-risk decisions, especially when high-risks were rewarded. The strategy analysis indicated that when high-risk options were rewarded, HC adopted a conservative risk strategy on the next trial by preferring the low-risk option (i.e., they counted their blessings and then played the surer bet). In contrast, following a rewarded high-risk choice, HD patients showed a clear preference for repeating the high-risk choice. Conclusions: These results indicate a pattern of high-risk/high-reward decision bias in HD that persists when outcomes and risks are certain. The allure of high-risk/high-reward decisions in situations of risk certainty and uncertainty expands our insight into the dynamic decision-making deficits that create considerable clinical burden in HD. (JINS, 2016, 22, 426–435)


2020 ◽  
Vol 10 (11) ◽  
Author(s):  
Beatrice Heim ◽  
Marina Peball ◽  
Carsten Saft ◽  
Sarah Maria Hein ◽  
Philipp Ellmerer ◽  
...  

2020 ◽  
Author(s):  
Brendan Gaesser ◽  
Zoe Fowler

Research in psychology, neuroscience, and philosophy has proposed a multifaceted view of human cognition and morality, establishing that inputs from multiple cognitive and affective processes such as theory of mind, semantic knowledge, and language guide moral judgment and decision-making. However, the extant perspective of moral cognition has largely overlooked a critical role for episodic representation. The ability to remember or imagine a specific moment in the past or future, supported by the medial temporal lobe subsystem, plays a broadly influential role in how people think, feel, and behave. Yet existing research has only just begun to explore the influence of episodic representation on moral judgment and decision-making. Here, we evaluate the theoretical connections between episodic representation and moral judgment, review emerging empirical work revealing how episodic representation affects moral judgment and decision-making, and conclude by highlighting gaps in the literature and future directions to explore. We argue that a comprehensive model of moral cognition will require including contributions of the episodic memory system, further delineating its direct influence on morality as well as better understanding how this system engages and interacts with other mental processes to fundamentally shape human morality.


Sign in / Sign up

Export Citation Format

Share Document