S-nitrosothiol inhibition of mitochondrial complex I causes a reversible increase in mitochondrial hydrogen peroxide production

The aim was to study thein vitroeffect of nM to low μM concentration of (+)-catechin on the enzymatic activities of mitochondrial complex I and mtNOS, as well as the consequences on the membrane potential and H2O2production rate.

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Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes

Critical Care Medicine ◽

10.1097/ccm.0000000000004095 ◽

2020 ◽

Vol 48 (2) ◽

pp. e133-e140 ◽

Cited By ~ 4

Author(s):

Lin Piao ◽

Yong-Hu Fang ◽

Robert B. Hamanaka ◽

Gökhan M. Mutlu ◽

Cameron Dezfulian ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Complex I ◽

Myocardial Stunning ◽

Mitochondrial Complex I ◽

Mitochondrial Complex ◽

Hydrogen Peroxide Production

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Inhibition of Mitochondrial Complex I Leads to Decreased Motility and Membrane Integrity Related to Increased Hydrogen Peroxide and Reduced ATP Production, while the Inhibition of Glycolysis Has Less Impact on Sperm Motility

PLoS ONE ◽

10.1371/journal.pone.0138777 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0138777 ◽

Cited By ~ 56

Author(s):

María Plaza Davila ◽

Patricia Martin Muñoz ◽

Jose A. Tapia ◽

Cristina Ortega Ferrusola ◽

Carolina Balao da Silva C ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Sperm Motility ◽

Complex I ◽

Membrane Integrity ◽

Mitochondrial Complex I ◽

Mitochondrial Complex ◽

Atp Production ◽

Inhibition Of Glycolysis

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Rotenone, Mitochondrial Complex I Inhibitor, Augments and Hydrogen Peroxide Inhibits L‐type Calcium Current in Arterial Smooth Muscle Cells

The FASEB Journal ◽

10.1096/fasebj.29.1_supplement.844.10 ◽

2015 ◽

Vol 29 (S1) ◽

Author(s):

Rikuo Ochi ◽

Vidhi Shah ◽

Dhara Patel ◽

Michael Wolin ◽

Sachin Gupte

Keyword(s):

Hydrogen Peroxide ◽

Smooth Muscle ◽

Smooth Muscle Cells ◽

Calcium Current ◽

Complex I ◽

Muscle Cells ◽

Mitochondrial Complex I ◽

Mitochondrial Complex ◽

Arterial Smooth Muscle Cells ◽

Mitochondrial Complex I Inhibitor

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Oxygen-sensing in the Lung is Regulated by Mitochondrial Complex I Ndufs2: Role of Mitochondria-derived Hydrogen Peroxide in Hypoxic Pulmonary Vasoconstriction

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2017.10.291 ◽

2017 ◽

Vol 112 ◽

pp. 186-187

Author(s):

Kimberly J Dunham-Snary ◽

Danchen Wu ◽

Edward A Sykes ◽

François Potus ◽

Jeffrey D Mewburn ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Complex I ◽

Oxygen Sensing ◽

Hypoxic Pulmonary Vasoconstriction ◽

Mitochondrial Complex I ◽

Mitochondrial Complex ◽

Pulmonary Vasoconstriction

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Effects of lithium treatment on oxidative stress markers in mitochondrial complex I and complex III inhibition and after CO2 exposure in SH-SY5Y cells

10.31487/j.nnb.2019.01.001 ◽

2019 ◽

Author(s):

Frederic Marmol

Keyword(s):

Oxidative Stress ◽

Complex I ◽

Lithium Treatment ◽

Complex Iii ◽

Mitochondrial Complex I ◽

Oxidative Stress Markers ◽

Mitochondrial Complex ◽

Stress Markers

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Faculty Opinions recommendation of Sequence variation in mitochondrial complex I genes: mutation or polymorphism?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1047896.497919 ◽

2006 ◽

Author(s):

Anders Oldfors

Keyword(s):

Complex I ◽

Sequence Variation ◽

Mitochondrial Complex I ◽

Mitochondrial Complex

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Faculty Opinions recommendation of Functional modules and structural basis of conformational coupling in mitochondrial complex I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3838956.4838055 ◽

2010 ◽

Author(s):

Thomas Meier

Keyword(s):

Complex I ◽

Structural Basis ◽

Mitochondrial Complex I ◽

Functional Modules ◽

Mitochondrial Complex ◽

Conformational Coupling

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Faculty Opinions recommendation of PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718319149.793497763 ◽

2014 ◽

Author(s):

Ted Dawson ◽

Sheila Pirooznia

Keyword(s):

Complex I ◽

Mitochondrial Complex I ◽

Loss Of Function ◽

Mitochondrial Complex ◽

Complex I Activity

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Faculty Opinions recommendation of Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718433724.793502240 ◽

2014 ◽

Author(s):

David Lee ◽

Hannah Heywood

Keyword(s):

Insulin Signaling ◽

Complex I ◽

Mitochondrial Complex I ◽

Skeletal Myogenesis ◽

Mitochondrial Complex ◽

Complex I Deficiency

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