High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies

2021 ◽  
pp. 166216
Author(s):  
S. Contreras-Duarte ◽  
C. Claudette ◽  
M. Farias ◽  
A. Leiva
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Total Cholesterol ◽  
High Total Cholesterol ◽  
Nitric Oxide Signaling

scholarly journals Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy

2011 ◽  
Vol 2011 ◽  
pp. 1-18 ◽  
Author(s):  
Andrea Leiva ◽  
Fabián Pardo ◽  
Marco A. Ramírez ◽  
Marcelo Farías ◽  
Paola Casanello ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Convincing Evidence ◽  
Amino Acid Transporters ◽  
Pathological State ◽  
Metabolic Marker ◽  
Obesity In Pregnancy ◽  
In Pregnancy

Gestational diabetes mellitus (GDM) and obesity in pregnancy (OP) are pathological conditions associated with placenta vascular dysfunction coursing with metabolic changes at the fetoplacental microvascular and macrovascular endothelium. These alterations are seen as abnormal expression and activity of the cationic amino acid transporters and endothelial nitric oxide synthase isoform, that is, the “endothelial L-arginine/nitric oxide signalling pathway.” Several studies suggest that the endogenous nucleoside adenosine along with insulin, and potentially arginases, are factors involved in GDM-, but much less information regards their role in OP-associated placental vascular alterations. There is convincing evidence that GDM and OP prone placental endothelium to an “altered metabolic state” leading to fetal programming evidenced at birth, a phenomenon associated with future development of chronic diseases. In this paper it is suggested that this pathological state could be considered as a metabolic marker that could predict occurrence of diseases in adulthood, such as cardiovascular disease, obesity, diabetes mellitus (including gestational diabetes), and metabolic syndrome.

scholarly journals Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia

2009 ◽  
Vol 28 (2) ◽  
pp. 72-81 ◽  
Author(s):  
Donovan McGrowder ◽  
Kevin Grant ◽  
Rachael Irving ◽  
Lorenzo Gordon ◽  
Tazhmoye Crawford ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Clinical Characteristics ◽  
Hdl Cholesterol ◽  
Normal Glucose Tolerance ◽  
Increased Risk ◽  
Normal Glucose

Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy-induced hypertension and other maternal and foetal complications of pregnancy. The aims of the study were to evaluate the serum lipid profile of women with GDM, and determine the number of women with GDM who have preeclampsia (PE). A retrospective study of 84 women with GDM and 90 pregnant women with normal glucose tolerance (controls) was conducted. Women with GDM had significantly higher parity (p=0.047), total cholesterol (p=0.039) and triglycerides (p=0.033), but non-significantly lower HDL-cholesterol (p=0.086) when compared to controls. Systolic blood pressure was significantly elevated in women with GDM coupled with PE (GDM-PE; p=0.015), the mean birth weight of infants born to women with GDM-PE was significantly lower than that of women with only GDM (p=0.025). Women with GDM-PE had significantly higher triglycerides (p=0.020), had to be more multi-gravida (p=0.047) with significantly elevated VLDL-cholesterol (p=0.037) when compared with women with only GDM. 11.9% of women with GDM had PE. On the basis of these findings, it can be concluded that GDM is associated with hyperlipidaemia as evident by the significantly elevated total cholesterol and triglyceride concentrations. Women with dyslipidaemia and GDM are at risk of developing preeclampsia. It is imperative that blood lipids be evaluated in women with GDM during antenatal care as it would be helpful in the early detection and treatment of PE.

Gestational diabetes mellitus was related to ambient air pollutant nitric oxide during early gestation

2017 ◽  
Vol 158 ◽  
pp. 318-323 ◽  
Author(s):  
Shih-Chun Pan ◽  
Ching-Chun Huang ◽  
Shio-Jean Lin ◽  
Bing-Yu Chen ◽  
Chang-Chuan Chan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Ambient Air ◽  
Air Pollutant ◽  
Early Gestation

Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation

2018 ◽  
Vol 17 (1) ◽  
pp. 52-71 ◽  
Author(s):  
Susana Contreras-Duarte ◽  
Lorena Carvajal ◽  
Bárbara Fuenzalida ◽  
Claudette Cantin ◽  
Luis Sobrevia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vascular Function ◽  
Physiological Adaptation ◽  
Aortic Atherosclerosis ◽  
Plasma Total Cholesterol ◽  
Foetal Development ◽  
In Pregnancy

Dyslipidaemia occurs in pregnancy to secure foetal development. The mother shows a physiological increase in plasma total cholesterol and Triglycerides (TG) as pregnancy progresses (i.e. maternal physiological dyslipidaemia in pregnancy). However, in some women pregnancy-associated dyslipidaemia exceeds this physiological adaptation. The consequences of this condition on the developing fetus include endothelial dysfunction of the foetoplacental vasculature and development of foetal aortic atherosclerosis. Gestational Diabetes Mellitus (GDM) associates with abnormal function of the foetoplacental vasculature due to foetal hyperglycaemia and hyperinsulinaemia, and associates with development of cardiovascular disease in adulthood. Supraphysiological dyslipidaemia is also detected in GDM pregnancies. Although there are several studies showing the alteration in the maternal and neonatal lipid profile in GDM pregnancies, there are no studies addressing the effect of dyslipidaemia in the maternal and foetal vasculature. The literature reviewed suggests that dyslipidaemia in GDM pregnancy should be an additional factor contributing to worsen GDM-associated endothelial dysfunction by altering signalling pathways involving nitric oxide bioavailability and neonatal lipoproteins.

Fetal sex in the development of gestational diabetes mellitus and endothelial dysfunction

2020 ◽  
Vol 9_2020 ◽  
pp. 56-64
Author(s):  
Botasheva T.L. Botasheva ◽  
Palieva N.V. Palieva ◽  
Khloponina A.V. Khloponina ◽  
Vasiljeva V.V. Vasiljeva ◽  
Zheleznyakova E.V. Zheleznyakova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fetal Sex
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