The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Background and aim Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. Methods One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. Results Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). Conclusion Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.

Transition from metabolically healthy to unhealth status associated with risk of carotid artery plaque in Chinese adults

Objective We aimed to evaluate the association between the shift of metabolic status and future risk of carotid artery plaque (CAP) in community-based Chinese adults. Methods The current study included 9836 Chinese adults (4085 males and 5751 females, mean age 35.8 years) with metabolically healthy status at baseline (2013). Metabolically healthy status was defined as no self-reported history of metabolic diseases and cancer, and normal blood pressure, fasting blood glucose, glycated hemoglobin A1c level, and lipid profiles. Metabolically unhealthy status was defined if any of the following metabolic abnormalities were confirmed twice during follow up: high blood pressure, impaired glucose regulation, high triglycerides, high total cholesterol, high low-density lipoprotein cholesterols, or low high-density lipoprotein cholesterols. The transition was confirmed if participants’ metabolic status shifted from baseline healthy to unhealthy status during follow up (2014–2018). Results We have identified 133 incident cases of CAP during follow up. Compared to those who remained metabolically healthy, the transition to high blood pressure, high total cholesterol, and high low-density lipoprotein cholesterols, were associated with high risk of developing carotid artery plaque (Hazards ratios (HRs) ranged from 1.69 to 2.34; p < 0.05 for all). The transition to impaired glucose regulation, high total triglycerides, and low high-density lipoprotein cholesterols, were associated with high risk of carotid artery plaque only in participants with metabolically healthy overweight at baseline (HR ranged from 1.95 to 4.62; p < 0.05 for all). Conclusion The transition from baseline metabolically healthy status to unhealth status was associated with high risk of incident CAP.

THE STATE OF CHOLESTEROL LEVEL IN HYPERTENSION IN SADANANYA HEALTH CENTER

Hypertension is an increase in systolic blood pressure above 140 mmHg and diastolic blood pressure above 90 mmHg. The number of hypertension sufferers has increased each year, in 2015 it reached 19,552, in 2016 it reached 24,750 and in 2017 it reached 38,057. In 2017 there were 115 hypertensive patients recorded in the report book that checked their health at the Sadananya Health Center. One of the causes of the high incidence of hypertension is cholesterol caused by the consumption of inappropriate food. One of the laboratory examinations to support hypertension diagnosis is blood cholesterol examination which can show excess cholesterol which makes hypertension difficult to control. To know the description of total cholesterol levels in hypertensive patients at the Sadananya Health Center. Quantitative descriptive, the population in this study were people with hypertension at the Sadananya Health Center. Sampling with accidental sampling, as many as 30 respondents. The cholesterol examination method used is CHOD-PAP. The results showed that blood pressure in respondents all had high blood pressure, namely >140/90 mmHg (100%), a high cholesterol level of 24 respondents (80%), blood pressure 140-150 who had high cholesterol as many 13 respondents, blood pressure 160-170 who had high cholesterol as much 6 respondents, blood pressure >180 who had high cholesterol as much 5 respondents. This study concludes that hypertensive clients have more high total cholesterol levels, which is as much as 80% and normal 20%. More hypertensive patients have high total cholesterol levels, which are 80% and 20% normal.

Mendelian Randomization of Dyslipidemia on Cognitive Impairment Among Older Americans

Background: Altered lipid metabolism may be a risk factor for dementia, and blood cholesterol level has a strong genetic component. We tested the hypothesis that dyslipidemia (either low levels of high-density lipoprotein cholesterol (HDL-C) or high total cholesterol) is associated with cognitive status and domains, and assessed causality using genetic predisposition to dyslipidemia as an instrumental variable.Methods: Using data from European and African genetic ancestry participants in the Health and Retirement Study, we selected observations at the first non-missing biomarker assessment (waves 2006–2012). Cognition domains were assessed using episodic memory, mental status, and vocabulary tests. Overall cognitive status was categorized in three levels (normal, cognitive impairment non-dementia, dementia). Based on 2018 clinical guidelines, we compared low HDL-C or high total cholesterol to normal levels. Polygenic scores for dyslipidemia were used as instrumental variables in a Mendelian randomization framework. Multivariable logistic regressions and Wald-type ratio estimators were used to examine associations.Results: Among European ancestry participants (n = 8,781), at risk HDL-C levels were associated with higher odds of cognitive impairment (OR = 1.20, 95% CI: 1.03, 1.40) and worse episodic memory, specifically. Using cumulative genetic risk for HDL-C levels as a valid instrumental variable, a significant causal estimate was observed between at risk low HDL-C levels and higher odds of dementia (OR = 2.15, 95% CI: 1.16, 3.99). No significant associations were observed between total cholesterol levels and cognitive status. No significant associations were observed in the African ancestry sample (n = 2,101).Conclusion: Our study demonstrates low blood HDL-C is a potential causal risk factor for impaired cognition during aging in non-Hispanic whites of European ancestry. Dyslipidemia can be modified by changing diets, health behaviors, and therapeutic strategies, which can improve cognitive aging. Studies on low density lipoprotein cholesterol, the timing of cholesterol effects on cognition, and larger studies in non-European ancestries are needed.

Prevalence and cardiovascular risk factors of carotid plaque in rural-dwelling adults: a population-based study in Shandong, China

Background The association between carotid plaque (CP) and cardiovascular risk factors (CRFs) remains elusive. And few studies focus on CRFs associated with multiple CPs and irregular CP. We aimed to investigate CRFs associated with the presence, number and irregular surface morphology of CP in rural-dwelling Chinese population. Methods This population-based study included 2021 participants who were aged ≥ 40 and free of stroke. Data were collected via interviews, clinical examinations, and laboratory tests. Carotid plaque was estimated by ultrasonography. Binary logistic and multinomial logistic regression models were used to analyze data. Results Of the 2021 participants, 774 (38.3%) were detected with CP. The multi-adjusted odds ratio (95% confidence interval) of CP was 1.75 (1.40–2.19) for hypertension, 1.62 (1.03–2.55) for low high-density lipoprotein cholesterol (HDL-C), 1.55 (1.20–2.01) for high hypersensitive C-reactive protein (hs-CRP), 1.41 (1.07–1.87) for diabetes mellitus (DM), 1.39 (1.00-1.93) for high total cholesterol and 1.38 (1.03–1.85) for high low-density lipoprotein cholesterol (LDL-C). When the number and surface morphology of CP were analyzed, hypertension, high hs-CRP, DM and high LDL-C were associated with multiple CPs; hypertension, high hs-CRP and high total cholesterol were associated with irregular CP. Conclusions Carotid plaque is common amongst middle-aged and older people living in rural China. Hypertension, low HDL-C, high hs-CRP, DM, high total cholesterol and high LDL-C may be associated independently with CP.

The Relationship Between Genetic Variants Associated with Premature Menopause and Lipid Profile in Women Recruited from MASHAD Cohort Study

Background and aim: Premature menopause (PM) is defined by the occurrence of the menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between PM-associated genotypes cardio metabolic disorder risk factors. Methods: One hundred seventeen women with PM and one hundred eighty-three healthy women without PM were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed.Results: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have high serum LDL risk (p = 0.03) compared to the control group. There was also a significant association between low serum HDL risk and rs2303369 and rs4806660 SNP genotypes in the PM group. In the PM group, the percentage of those with a high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03).Conclusion: Some SNPs reported to be associated with PM appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with PM who may be susceptible to CVD.

Risk Factors of Non-Communicable Diseases in a Frontier, Outermost, and Least Developed (3T) Archipelagic Region of Indonesia: a Community Study

Health is a universal right for all mankind, including those living in Indonesia’s Frontier, Outermost, and Least Developed areas also known as 3T Regions. Ilngei and Kabiarat Villages, which were the locations of our community study, are one of the villages belong to such regions of Western Southeast Maluku Regency—or Tanimbar Islands. In addition to difficulty of achieving equitable health workers and facilities distribution, indigenous people have also been found to live some unhealthy lifestyles including routine consumption of local made alcohol beverages known as sopi and smoking habits. This situation could be a risk factor for non-communicable diseases (NCD) such as hypertension, diabetes mellitus (DM), and high blood cholesterol. Therefore, our KKN-PPM UGM team conducted a community service activity in form of a free health check-up. This activity was aimed to screen health conditions particularly exploring NCDs risk factors, increase public awareness of health, and provide a reference for further health interventions and researches in this area. This research is an observational descriptive study, with primary data obtained during health check-up. The health check-up was carried out separately in two villages respectively on January 18th and 25th, 2020. Participants were recruited with purposive sampling, through invitation determined by the team. We used a digital blood pressure monitor to measure blood pressure and automatic skin-prick test device to measure capillary random blood sugar and total cholesterol level. Out of 102 participants, those classified as pre-hypertension were 33 people (32.35%), stage I hypertension were 22 people (21.56%), stage II hypertension were 32 people (31.37%), uncertain DM were 55 people (57.89%), DM were 4 people (4.21%), borderline high total cholesterol level were 13 people (20.31%), and high total cholesterol level was 1 person (1.56%). Overall, the majority of participants had blood pressure and blood sugar level above the normal range. This kind of activity should be made on a regular basis to reach more number of participants and more detail information regarding NCDs risk factors.

Patterns of change in cardiovascular risks of Korean male workers: a 10-year cohort analysis using the National Health Insurance Service–National Sample Cohort (NHIS-NSC) 2.0 database

ObjectiveHealth behaviour is one of the major determinants of cardiovascular diseases in working population. This study was tried to investigate the trend of cardiovascular health level, the relationship between continuous health behaviours, and changes in the risk of cardiovascular diseases of male workers by using a nationwide database.DesignThis study is a retrospective cohort study.Setting and participantsThe study analysed data of 57 837 male workers whose personal health examination data were continuously traced using Korea’s National Health Insurance Service–National Sample Cohort 2.0 database.Primary outcome measuresA 10-year trend for all cardiovascular risks and change for the risks according to the consistent performance of healthy behaviours.ResultsThe results showed that the risk of being overweight (adjusted OR (aOR) 1.63, 95% CI 1.59 to 1.68) and obese (aOR 1.51, 95% CI 1.47 to 1.56) increased. The index of cardiovascular risk also increased for high fasting glucose (aOR 1.77, 95% CI 1.62 to 1.95) and high total cholesterol (aOR 1.68, 95% CI 1.60 to 1.76), respectively. The risks of high fasting glucose (aOR 2.09, 95% CI 1.40 to 3.13), high triglycerides (aOR 1.27, 95% CI 1.14 to 1.42) and high low-density lipoprotein cholesterol (aOR 1.38, 95% CI 1.14 to 1.66) were increased among high-risk smokers. Similarly, the risk of high total cholesterol (aOR 2.20, 95% CI 1.35 to 3.58) and high triglycerides (aOR 1.42, 95% CI 1.09 to 1.85) were increased among high-risk drinkers. In addition, the increase in the risk of being overweight (aOR 2.20, 95% CI 1.83 to 2.65) and obese (aOR 1.90, 95% CI 1.59 to 2.27) were analysed among who had not consistently exercised.ConclusionsSince the pattern of change in the level of cardiovascular risk related to the continuous health behaviours of male workers was identified, the findings of the present study can be used as basic data to develop health promotion policies for the population.