Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency

Author(s):  
Ephraim Yavin ◽  
Yu Hong Lin ◽  
Annette Brand ◽  
Norman Salem
1965 ◽  
Vol 87 (2) ◽  
pp. 168-172 ◽  
Author(s):  
R. B. Alfin-Slater ◽  
R. S. Morris ◽  
H. Hansen ◽  
J. F. Proctor

1943 ◽  
Vol 6b (2) ◽  
pp. 109-112 ◽  
Author(s):  
B. E. Bailey

Pilchard oil and two fractions of salmon egg oil, despite their greater unsaturation, proved less effective than methyl linoleate in curing rats suffering from essential fatty acid deficiency. Herring oil, less unsaturated, was even less effective.


1973 ◽  
Vol 52 (3) ◽  
pp. 462-466 ◽  
Author(s):  
R.E.S. Prout ◽  
F.C. Tring

Light microscopic examination was done of sagittal sections of mandibular incisors from Wistar rats maintained on a normal cube diet, a synthetic fat-supplemented diet and a fat-free diet. Extensive histologic changes were observed in odontoblasts and dentin formation in rats maintained on the fat-free diet. These changes were considered to be degenerative and to be concomitant with essential fatty acid deficiency.


1972 ◽  
Vol 27 (2) ◽  
pp. 365-374 ◽  
Author(s):  
D. Sklan ◽  
R. Volcani ◽  
P. Budowski

1. Groups of newborn calves were fed on liquid diets which had fat contents ranging from 0.2 to 17% (dry- weight basis) and which provided linoleic acid in amounts ranging from 0.01 to 0.7% of the calorie intake. Two commercial milk replacers, high in fat (17–18%) and linoleic acid (3.4 and 5.0% of calories) were also given. All diets were given for at least 65 d.2. Except for reduced feed utilization associated with the two diets lowest in fat (0.2 and 0.4%), the calves developed normally, without signs of essential fatty acid deficiency.3. The polyunsaturated fatty acid content of erthrocytes and plasma phospholipids and cholesteryl esters rose rapidly during the first few days on all diets. At 65 d, these concentrations were higher than at birth and appeared generally to be related to the linoleic acid intake. However, in the low dietary linoleic acid range, the fat content of the diet also seemed to exert some influnce. In no instance was there any indication of the appearance of 20:3ω9, which is observed in other species under conditions of essential fatty acid deficiency.4. Some of the experimental diets were given to weanling rats. There was a rapid fall in the polyunsaturated fatty acid content of erythrocyte lipids and plasma phospholipids and cholesteryl esters, accompanied by the appearance of 20:3ω9.5. These results suggest that calves on liquid diets have apparently a very low requirement for essential fatty acids.


1970 ◽  
Vol 48 (9) ◽  
pp. 631-639 ◽  
Author(s):  
M. Yurkowski ◽  
B. L. Walker

Mucosal lipids were isolated from the proximal, middle, and distal intestinal sections of rats fed diets containing either 10% corn oil or 10% hydrogenated coconut oil, the latter diet being deficient in essential fatty acids. By a combination of column and thin-layer chromatography, the lipids were fractionated and the major components found to consist of triglycerides, free fatty acids, cholesterol, phosphatidylcholine, and phosphatidylethanolamine. Several minor constituents were present. Triglycerides and free fatty acids were generally present in higher concentrations in animals fed corn oil, and the concentration of mucosal triglycerides decreased towards the distal end of the intestine whereas free fatty acids increased in this group. Essential fatty acid deficiency resulted in lower levels of linoleic and arachidonic acids and higher levels of palmitoleic, oleic, and eicosatrienoic acids in the mucosal lipids. Mono- and di-enoic fatty acids tended to decrease in concentration from the proximal to the distal end of the intestine; the polyunsaturated acids and, to some extent, the saturated acids, were lowest in the proximal section of the intestine.


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