HDL functionality in reverse cholesterol transport — Challenges in translating data emerging from mouse models to human disease

2016 ◽  
Vol 1861 (7) ◽  
pp. 566-583 ◽  
Author(s):  
Miriam Lee-Rueckert ◽  
Joan Carles Escola-Gil ◽  
Petri T. Kovanen
Keyword(s):  
Mouse Models ◽  
Human Disease ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Hdl Functionality

Mechanisms for Cellular Cholesterol Transport: Defects and Human Disease

2006 ◽  
Vol 86 (4) ◽  
pp. 1237-1261 ◽  
Author(s):  
Elina Ikonen
Keyword(s):  
Mouse Models ◽  
Human Disease ◽  
Human Diseases ◽  
Cholesterol Transport ◽  
Cholesterol Trafficking ◽  
Cellular Cholesterol ◽  
Intracellular Cholesterol

This review summarizes the mechanisms of cellular cholesterol transport and monogenic human diseases caused by defects in intracellular cholesterol processing. In addition, selected mouse models of disturbed cholesterol trafficking are discussed. Current pharmacological strategies to prevent atherosclerosis are largely based on altering cellular cholesterol balance and are introduced in this context. Finally, because of the organizing potential of cholesterol in membranes, disturbances in cellular cholesterol transport have implications for a wide variety of human diseases, of which selected examples are given.

scholarly journals Extra Virgin Olive Oil Polyphenols Promote Cholesterol Efflux and Improve HDL Functionality

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hicham Berrougui ◽  
Souad Ikhlef ◽  
Abdelouahed Khalil
Keyword(s):  
Oxidative Stress ◽  
Reverse Cholesterol Transport ◽  
Transport Process ◽  
Cholesterol Efflux ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Cholesterol Transport ◽  
Oxidative Damages ◽  
Hdl Functionality

Results of the present work give evidence from the beneficial role of extra virgin olive of oil (EVOO) consumption towards oxidative stress and cardiovascular diseases. Polyphenols contained in EVOO are responsible for inhibiting lipoproteins oxidative damages and promoting reverse cholesterol transport process via ABCA1 pathway.

Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport

2015 ◽  
Vol 26 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Nathalie Nicod ◽  
Robert S. Parker ◽  
Elena Giordano ◽  
Virginia Maestro ◽  
Alberto Davalos ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Specific Effects ◽  
Hdl Functionality

Reverse Cholesterol Transport in Plasma of Patients With Different Forms of Familial HDL Deficiency

1995 ◽  
Vol 15 (5) ◽  
pp. 691-703 ◽  
Author(s):  
Arnold von Eckardstein ◽  
Yadong Huang ◽  
Shili Wu ◽  
Harald Funke ◽  
Giorgio Noseda ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Cholesterol Transport

Smoking prevents the intravascular remodeling of high-density lipoprotein particles: implications for reverse cholesterol transport

Metabolism ◽  
2004 ◽  
Vol 53 (7) ◽  
pp. 858-862 ◽  
Author(s):  
Águeda C.M Zaratin ◽  
Eder C.R Quintão ◽  
Andrei C Sposito ◽  
Valéria S Nunes ◽  
Ana Maria Lottenberg ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Reverse Cholesterol Transport ◽  
Density Lipoprotein ◽  
High Density ◽  
Cholesterol Transport ◽  
Lipoprotein Particles
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