scholarly journals Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-estradiol involves differential regulation of plasma membrane associated estrogen receptors

2013 ◽  
Vol 1833 (5) ◽  
pp. 1165-1172 ◽  
Author(s):  
Khairat B.Y. Elbaradie ◽  
Yun Wang ◽  
Barbara D. Boyan ◽  
Zvi Schwartz
Keyword(s):  
Plasma Membrane ◽  
Estrogen Receptors ◽  
Growth Plate ◽  
Differential Regulation ◽  
Specific Response ◽  
Cartilage Growth ◽  
Growth Plate Chondrocytes ◽  
17Β Estradiol ◽  
Cartilage Growth Plate

scholarly journals Differential Regulation of Gonadotropin Receptors (fshr and lhcgr) by Estradiol in the Zebrafish Ovary Involves Nuclear Estrogen Receptors That Are Likely Located on the Plasma Membrane

Endocrinology ◽  
2011 ◽  
Vol 152 (11) ◽  
pp. 4418-4430 ◽  
Author(s):  
Ka-Cheuk Liu ◽  
Sze-Wah Lin ◽  
Wei Ge
Keyword(s):  
Plasma Membrane ◽  
Estrogen Receptors ◽  
State Level ◽  
Fold Increase ◽  
Follicle Cell ◽  
Differential Regulation ◽  
Primary Follicle ◽  
Endocrine Hormone ◽  
17Β Estradiol ◽  
Nuclear Estrogen Receptors

FSH and LH are gonadotropins (GTH) that control all major events of gonadal function. FSH and LH signal through their cognate receptors, FSH receptor and LH/choriogonadotropin receptor, respectively, across vertebrates. Compared with the information in mammals, very little is known about these receptors in fish, especially the regulation of their expression. In female zebrafish, fshr and lhcgr exhibit significant temporal difference in expression, with fshr increasing first when the follicles are activated to enter the vitellogenic growth phase and lhcgr lagging behind. This raises an interesting question on the differential regulation of these two GTH receptors (GTHR) during folliculogenesis. Using a primary follicle cell culture, the present study demonstrated that 17β-estradiol (E2), but not testosterone, was a potent endocrine hormone that differentially regulated the expression of fshr and lhcgr. Although E2 stimulated both receptors, its effect on the steady-state level of lhcgr mRNA was much higher (>8-fold up-regulation) than that of fshr (∼0.5-fold increase). E2 likely acted at the transcription level via its nuclear estrogen receptors (ERα and ERβ), because ICI 182,780 could abolish its effects. However, our evidence suggested that these receptors might be localized on the plasma membrane, because β-estradiol 6-(O-carboxy methyl)oxime:BSA could fully mimic the effects of E2. Demonstrating that E2 is likely one of the differentiating factors for the distinct expression of the two GTHR in the zebrafish ovary, this study sheds important light on the functions of the two GTH and their receptors in fish as well as the conservation and diverse aspects of GTHR regulation across vertebrates.

PTH/PTHrP receptor mRNA is down-regulated in epiphyseal cartilage growth plate of uraemic rats

1996 ◽  
Vol 11 (10) ◽  
pp. 2008-2016 ◽  
Author(s):  
P. Urena ◽  
A. Ferreira ◽  
C. Morieux ◽  
T. Drueke ◽  
M. Christine de Vernejoul
Keyword(s):  
Growth Plate ◽  
Epiphyseal Cartilage ◽  
Cartilage Growth ◽  
Receptor Mrna ◽  
Pthrp Receptor ◽  
Cartilage Growth Plate

Stimulation of catecholamine synthesis through unique estrogen receptors in the bovine adrenomedullary plasma membrane by 17β-estradiol

2006 ◽  
Vol 339 (2) ◽  
pp. 548-553 ◽  
Author(s):  
Nobuyuki Yanagihara ◽  
Minhui Liu ◽  
Yumiko Toyohira ◽  
Masato Tsutsui ◽  
Susumu Ueno ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Estrogen Receptors ◽  
Catecholamine Synthesis ◽  
17Β Estradiol ◽  
Stimulation Of

scholarly journals SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling

2015 ◽  
Vol 30 (9) ◽  
pp. 1560-1571 ◽  
Author(s):  
Kenji Kato ◽  
Pallavi Bhattaram ◽  
Alfredo Penzo‐Méndez ◽  
Abhilash Gadi ◽  
Véronique Lefebvre
Keyword(s):  
Transcription Factors ◽  
Wnt Signaling ◽  
Growth Plate ◽  
Mouse Embryos ◽  
Cartilage Growth ◽  
Plate Formation ◽  
Cartilage Growth Plate
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