Abstract # 1839 Lentiviral overexpression of interleukin-1β in the hippocampus induces neurogenesis-associated cognitive deficits in adult male Sprague–Dawley rats

2016 ◽  
Vol 57 ◽  
pp. e37
Author(s):  
C.M. Hueston ◽  
C.S. Ó’Léime ◽  
D.A. Kozareva ◽  
J.F. Cryan ◽  
Y.M. Nolan
Keyword(s):  
Adult Male ◽  
Cognitive Deficits ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Hepatic effects of a highly purified PCB 180 in adult male and female Sprague–Dawley rats

2008 ◽  
Vol 180 ◽  
pp. S39-S40
Author(s):  
Robert Roos ◽  
Patrik Andersson ◽  
Päivi Heikkinen ◽  
Hans-Joachim Schmitz ◽  
Leo van der Ven ◽  
...  
Keyword(s):  
Adult Male ◽  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats

scholarly journals Effects of Aqueous Quassia amara L. (Korales) Leaf Extract on the Cardiovascular and Respiratory Functions of Male Sprague-Dawley Rats

2018 ◽  
Vol 52 (6) ◽  
Author(s):  
Maria Concepcion C. Sison ◽  
Lynn Crisanta R. Panganiban ◽  
Daisy Mae A. Bagaoisan ◽  
Nelia P. Cortes-Maramba
Keyword(s):  
Blood Pressure ◽  
Adult Male ◽  
Leaf Extract ◽  
Sprague Dawley ◽  
Treatment Groups ◽  
Respiratory Flow ◽  
Sprague Dawley Rats ◽  
Parallel Group ◽  
Aqueous Leaf Extract ◽  
Quassia Amara

Objective. To To evaluate potential effects of the aqueous extract of Quassia amara L. leaves on the cardiovascular and respiratory systems of adult male Sprague- Dawley rats. Methods. The cardiovascular and respiratory effects of the Quassia amara L. leaf extract on adult male SpragueDawley rats were assessed using non-invasive blood pressure (NIBP) determination and head-out plethysmography, respectively, in a randomized, parallel group study. Mean observations of blood pressure and heart rate were recorded at different time periods after dosing. Respiratory flow and irritation effects were evaluated using mean observations of respiratory rate (RR), tidal volume (TV), mid-expiratory flow rate (EF50), time of inspiration (TI) and expiration (TE), and time of break (TB) and pause (TP). Results. There were no significant differences among the control and the treatment groups in SBP, DBP and HR parameters. The extract showed statistically significant effect on mean RR by time period (F=2.45, p=0.0234), trends over time of TV among the dose groups (F=2.00, p=0.0202), and EF50 among dose groups ((F=3.11, p=0.0422). However, these did not correlate with the changes in the time of break (TB) and time of pause (TP) which are more sensitive and specific tests for respiratory irritation. Conclusion. Aqueous leaf extract of Quassia appeared to have no significant effects on SBP, DPB, Pulse pressure, and HR. There are no conclusive dose-related respiratory flow or pulmonary irritation effects.

Morphine drug discrimination testing and substitution assessments in adult male Sprague–Dawley rats

2013 ◽  
Vol 68 (1) ◽  
pp. e9
Author(s):  
Jonathan Toot ◽  
Michelle Hackman ◽  
Timothy Pringle ◽  
Melissa Beck ◽  
Philip Atterson ◽  
...  
Keyword(s):  
Drug Discrimination ◽  
Adult Male ◽  
Sprague Dawley ◽  
Discrimination Testing ◽  
Sprague Dawley Rats

Duodenal sucrose and glucose infusions enhance suppression by cholecystokinin of sham feeding

1994 ◽  
Vol 266 (2) ◽  
pp. R466-R471
Author(s):  
J. E. Cox
Keyword(s):  
Adult Male ◽  
Normal Saline ◽  
Sprague Dawley ◽  
Sham Feeding ◽  
Behavioral Observations ◽  
Sprague Dawley Rats

In two experiments I examined whether intraduodenal sucrose and glucose would enhance inhibition of sham feeding by cholecystokinin-8 (CCK-8). In the first experiment, adult male Sprague-Dawley rats received infusions of 0.88 M (30%, wt/vol) sucrose or normal saline at 0.51 ml/min for the first 7.67 min of 30-min sham-feeding tests. Tests began 10 min after intraperitoneal injections of saline or 0.5, 1, or 2 micrograms/kg CCK-8. When sucrose was infused, all doses of CCK-8 reduced sham feeding of 0.88 M sucrose by 60% or more, but with saline infusions, only the highest dose was effective. In the second experiment, rats received 30-min infusions of 0.3 M (5.4%) or 0.6 M (10.8%) glucose or equimolar saline at 0.388 ml/min. Although 1 microgram/kg CCK-8 was ineffective in the absence of infusions, it significantly reduced intake in combination with both concentrations of glucose and hypertonic (0.6 M) saline. Behavioral observations indicated that reductions in intake were attributable primarily to decreased meal length and slower intake. These results suggest that an intestinal signal may contribute to the previously reported ability of preloads to potentiate CCK satiety.

scholarly journals Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats

2015 ◽  
Vol 37 (3) ◽  
pp. 253-262 ◽  
Author(s):  
Susan B. Powell ◽  
Asma Khan ◽  
Jared W. Young ◽  
Christine N. Scott ◽  
Mahalah R. Buell ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Cognitive Deficits ◽  
Time Course ◽  
Social Contact ◽  
Isolation Rearing ◽  
Sprague Dawley ◽  
Learning Deficits ◽  
Learning Impairments ◽  
Sprague Dawley Rats ◽  
Unique Model

Cognitive impairments appear early in the progression of schizophrenia, often preceding the symptoms of psychosis. Thus, the systems subserving these functions may be more vulnerable to, and mechanistically linked with, the initial pathology. Understanding the trajectory of behavioral and anatomical abnormalities relevant to the schizophrenia prodrome and their sensitivity to interventions in relevant models will be critical to identifying early therapeutic strategies. Isolation rearing of rats is an environmental perturbation that deprives rodents of social contact from weaning through adulthood and produces behavioral and neuronal abnormalities that mirror some pathophysiology associated with schizophrenia, e.g. frontal cortex abnormalities and prepulse inhibition (PPI) of startle deficits. Previously, we showed that PPI deficits in isolation-reared rats emerge in mid-adolescence (4 weeks after weaning; approx. postnatal day 52) but are not present when tested at 2 weeks after weaning (approx. postnatal day 38). Because cognitive deficits are reported during early adolescence, are relevant to the prodrome, and are linked to functional outcome, we examined the putative time course of reversal learning deficits in isolation-reared rats. Separate groups of male Sprague Dawley rats were tested in a two-choice discrimination task at 2 and 8 weeks after weaning, on postnatal day 38 and 80, respectively. The isolation-reared rats displayed impaired reversal learning at both time points. Isolation rearing was also associated with deficits in PPI at 4 and 10 weeks after weaning. The reversal learning deficits in the isolated rats were accompanied by reductions in parvalbumin immunoreactivity, a marker for specific subpopulations of GABAergic neurons, in the hippocampus. Hence, isolation rearing of rats may offer a unique model to examine the ontogeny of behavioral and neurobiological alterations that may be relevant to preclinical models of prodromal psychosis.

Immune Complex Deposition in Adult Male Sprague-Dawley Rats Chronically Immunized with GnRH

2005 ◽  
Vol 54 (5) ◽  
pp. 292-310 ◽  
Author(s):  
Louis Vargas ◽  
Richard Sewell ◽  
Aileen Marshall ◽  
Josephine Galatioto ◽  
Yun-Yen Tsong ◽  
...  
Keyword(s):  
Immune Complex ◽  
Adult Male ◽  
Sprague Dawley ◽  
Immune Complex Deposition ◽  
Sprague Dawley Rats ◽  
Complex Deposition
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