Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague–Dawley rats: An isobologram analysis

Neuroscience ◽  
2016 ◽  
Vol 317 ◽  
pp. 173-183 ◽  
Author(s):  
N. Ahmadi-Mahmoodabadi ◽  
M. Nasehi ◽  
M. Emam Ghoreishi ◽  
M.-R. Zarrindast
Keyword(s):  
Synergistic Effect ◽  
Adult Male ◽  
Memory Consolidation ◽  
Cb1 Receptors ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Isobologram Analysis

Serotonin depletion reduces both acquisition and expression of context-conditioned fear

2021 ◽  
pp. 1-8
Author(s):  
S. Melker Hagsäter ◽  
Robert Pettersson ◽  
Axel Holmäng ◽  
Elias Eriksson
Keyword(s):  
Unconditioned Stimulus ◽  
Memory Consolidation ◽  
Clinical Studies ◽  
Conditioned Fear ◽  
Sprague Dawley ◽  
Serotonin Synthesis ◽  
Synthesis Inhibitor ◽  
Serotonin Depletion ◽  
Sprague Dawley Rats ◽  
The Impact

Abstract Objective: Whereas numerous experimental and clinical studies suggest a complex involvement of serotonin in the regulation of anxiety, it remains to be clarified if the dominating impact of this transmitter is best described as anxiety-reducing or anxiety-promoting. The aim of this study was to assess the impact of serotonin depletion on acquisition, consolidation, and expression of conditioned fear. Methods: Male Sprague–Dawley rats were exposed to foot shocks as unconditioned stimulus and assessed with respect to freezing behaviour when re-subjected to context. Serotonin depletion was achieved by administration of a serotonin synthesis inhibitor, para-chlorophenylalanine (PCPA) (300 mg/kg daily × 3), (i) throughout the period from (and including) acquisition to (and including) expression, (ii) during acquisition but not expression, (iii) after acquisition only, and (iv) during expression only. Results: The time spent freezing was significantly reduced in animals that were serotonin-depleted during the entire period from (and including) acquisition to (and including) expression, as well as in those being serotonin-depleted during either acquisition only or expression only. In contrast, PCPA administrated immediately after acquisition, that is during memory consolidation, did not impact the expression of conditioned fear. Conclusion: Intact serotonergic neurotransmission is important for both acquisition and expression of context-conditioned fear.

Hepatic effects of a highly purified PCB 180 in adult male and female Sprague–Dawley rats

2008 ◽  
Vol 180 ◽  
pp. S39-S40
Author(s):  
Robert Roos ◽  
Patrik Andersson ◽  
Päivi Heikkinen ◽  
Hans-Joachim Schmitz ◽  
Leo van der Ven ◽  
...  
Keyword(s):  
Adult Male ◽  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats

scholarly journals Effects of Aqueous Quassia amara L. (Korales) Leaf Extract on the Cardiovascular and Respiratory Functions of Male Sprague-Dawley Rats

2018 ◽  
Vol 52 (6) ◽  
Author(s):  
Maria Concepcion C. Sison ◽  
Lynn Crisanta R. Panganiban ◽  
Daisy Mae A. Bagaoisan ◽  
Nelia P. Cortes-Maramba
Keyword(s):  
Blood Pressure ◽  
Adult Male ◽  
Leaf Extract ◽  
Sprague Dawley ◽  
Treatment Groups ◽  
Respiratory Flow ◽  
Sprague Dawley Rats ◽  
Parallel Group ◽  
Aqueous Leaf Extract ◽  
Quassia Amara

Objective. To To evaluate potential effects of the aqueous extract of Quassia amara L. leaves on the cardiovascular and respiratory systems of adult male Sprague- Dawley rats. Methods. The cardiovascular and respiratory effects of the Quassia amara L. leaf extract on adult male SpragueDawley rats were assessed using non-invasive blood pressure (NIBP) determination and head-out plethysmography, respectively, in a randomized, parallel group study. Mean observations of blood pressure and heart rate were recorded at different time periods after dosing. Respiratory flow and irritation effects were evaluated using mean observations of respiratory rate (RR), tidal volume (TV), mid-expiratory flow rate (EF50), time of inspiration (TI) and expiration (TE), and time of break (TB) and pause (TP). Results. There were no significant differences among the control and the treatment groups in SBP, DBP and HR parameters. The extract showed statistically significant effect on mean RR by time period (F=2.45, p=0.0234), trends over time of TV among the dose groups (F=2.00, p=0.0202), and EF50 among dose groups ((F=3.11, p=0.0422). However, these did not correlate with the changes in the time of break (TB) and time of pause (TP) which are more sensitive and specific tests for respiratory irritation. Conclusion. Aqueous leaf extract of Quassia appeared to have no significant effects on SBP, DPB, Pulse pressure, and HR. There are no conclusive dose-related respiratory flow or pulmonary irritation effects.

Morphine drug discrimination testing and substitution assessments in adult male Sprague–Dawley rats

2013 ◽  
Vol 68 (1) ◽  
pp. e9
Author(s):  
Jonathan Toot ◽  
Michelle Hackman ◽  
Timothy Pringle ◽  
Melissa Beck ◽  
Philip Atterson ◽  
...  
Keyword(s):  
Drug Discrimination ◽  
Adult Male ◽  
Sprague Dawley ◽  
Discrimination Testing ◽  
Sprague Dawley Rats

Duodenal sucrose and glucose infusions enhance suppression by cholecystokinin of sham feeding

1994 ◽  
Vol 266 (2) ◽  
pp. R466-R471
Author(s):  
J. E. Cox
Keyword(s):  
Adult Male ◽  
Normal Saline ◽  
Sprague Dawley ◽  
Sham Feeding ◽  
Behavioral Observations ◽  
Sprague Dawley Rats

In two experiments I examined whether intraduodenal sucrose and glucose would enhance inhibition of sham feeding by cholecystokinin-8 (CCK-8). In the first experiment, adult male Sprague-Dawley rats received infusions of 0.88 M (30%, wt/vol) sucrose or normal saline at 0.51 ml/min for the first 7.67 min of 30-min sham-feeding tests. Tests began 10 min after intraperitoneal injections of saline or 0.5, 1, or 2 micrograms/kg CCK-8. When sucrose was infused, all doses of CCK-8 reduced sham feeding of 0.88 M sucrose by 60% or more, but with saline infusions, only the highest dose was effective. In the second experiment, rats received 30-min infusions of 0.3 M (5.4%) or 0.6 M (10.8%) glucose or equimolar saline at 0.388 ml/min. Although 1 microgram/kg CCK-8 was ineffective in the absence of infusions, it significantly reduced intake in combination with both concentrations of glucose and hypertonic (0.6 M) saline. Behavioral observations indicated that reductions in intake were attributable primarily to decreased meal length and slower intake. These results suggest that an intestinal signal may contribute to the previously reported ability of preloads to potentiate CCK satiety.

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