Histomorphology, Sperm Quality and Hormonal Profile in Adult Male Sprague-Dawley Rats following administration of aqueous crude Extract of Solanum nigrum by gastric gavage

Previous studies found that Kelulut Honey produced by Trigona spp. bees is able to prevent oxidative damage in various pathological conditions. Thus, the present study aimed to determine whether Kelulut Honey could prevent the sperm and testicular damage in streptozotocin-induced diabetic rats. Male Adult male Sprague-Dawley rats were divided into four groups: Non-Diabetic (NDM), Non-Diabetic with Kelulut Honey supplementation (NDMKH), Diabetic without supplementation (DM) and Diabetic with Kelulut Honey supplementation (DMKH). Kelulut honey was given at the dose of 2.0 g/kg weight daily via gavage for 28 consecutive days. Results showed that sperm quality produced by diabetic rats supplemented with Kelulut honey significantly improved compared to the diabetic control groups (p<0.05). SOD activity and GSH level increased significantly (p<0.05) whereas PC and MDA levels significantly decreased in sperm and testis of DMKH rats when compared to DM rats (p<0.05). Histological observation showed obvious increase in spermatozoa in the lumen of epididymis and increased spermatogenic cells density in the testis of DMKH group. In conclusion, Kelulut Honey has a potential in preventing the damage of sperm and testis in diabetic rats.

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Effects of Aqueous Quassia amara L. (Korales) Leaf Extract on the Cardiovascular and Respiratory Functions of Male Sprague-Dawley Rats

Acta Medica Philippina ◽

10.47895/amp.v52i6.280 ◽

2018 ◽

Vol 52 (6) ◽

Author(s):

Maria Concepcion C. Sison ◽

Lynn Crisanta R. Panganiban ◽

Daisy Mae A. Bagaoisan ◽

Nelia P. Cortes-Maramba

Keyword(s):

Blood Pressure ◽

Adult Male ◽

Leaf Extract ◽

Sprague Dawley ◽

Treatment Groups ◽

Respiratory Flow ◽

Sprague Dawley Rats ◽

Parallel Group ◽

Aqueous Leaf Extract ◽

Quassia Amara

Objective. To To evaluate potential effects of the aqueous extract of Quassia amara L. leaves on the cardiovascular and respiratory systems of adult male Sprague- Dawley rats. Methods. The cardiovascular and respiratory effects of the Quassia amara L. leaf extract on adult male SpragueDawley rats were assessed using non-invasive blood pressure (NIBP) determination and head-out plethysmography, respectively, in a randomized, parallel group study. Mean observations of blood pressure and heart rate were recorded at different time periods after dosing. Respiratory flow and irritation effects were evaluated using mean observations of respiratory rate (RR), tidal volume (TV), mid-expiratory flow rate (EF50), time of inspiration (TI) and expiration (TE), and time of break (TB) and pause (TP). Results. There were no significant differences among the control and the treatment groups in SBP, DBP and HR parameters. The extract showed statistically significant effect on mean RR by time period (F=2.45, p=0.0234), trends over time of TV among the dose groups (F=2.00, p=0.0202), and EF50 among dose groups ((F=3.11, p=0.0422). However, these did not correlate with the changes in the time of break (TB) and time of pause (TP) which are more sensitive and specific tests for respiratory irritation. Conclusion. Aqueous leaf extract of Quassia appeared to have no significant effects on SBP, DPB, Pulse pressure, and HR. There are no conclusive dose-related respiratory flow or pulmonary irritation effects.

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Abstract # 1839 Lentiviral overexpression of interleukin-1β in the hippocampus induces neurogenesis-associated cognitive deficits in adult male Sprague–Dawley rats

Brain Behavior and Immunity ◽

10.1016/j.bbi.2016.07.123 ◽

2016 ◽

Vol 57 ◽

pp. e37

Author(s):

C.M. Hueston ◽

C.S. Ó’Léime ◽

D.A. Kozareva ◽

J.F. Cryan ◽

Y.M. Nolan

Keyword(s):

Adult Male ◽

Cognitive Deficits ◽

Sprague Dawley ◽

Sprague Dawley Rats

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Morphine drug discrimination testing and substitution assessments in adult male Sprague–Dawley rats

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2013.01.041 ◽

2013 ◽

Vol 68 (1) ◽

pp. e9

Author(s):

Jonathan Toot ◽

Michelle Hackman ◽

Timothy Pringle ◽

Melissa Beck ◽

Philip Atterson ◽

...

Keyword(s):

Drug Discrimination ◽

Adult Male ◽

Sprague Dawley ◽

Discrimination Testing ◽

Sprague Dawley Rats

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Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague–Dawley rats: An isobologram analysis

Neuroscience ◽

10.1016/j.neuroscience.2015.12.010 ◽

2016 ◽

Vol 317 ◽

pp. 173-183 ◽

Cited By ~ 8

Author(s):

N. Ahmadi-Mahmoodabadi ◽

M. Nasehi ◽

M. Emam Ghoreishi ◽

M.-R. Zarrindast

Keyword(s):

Synergistic Effect ◽

Adult Male ◽

Memory Consolidation ◽

Cb1 Receptors ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Isobologram Analysis

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Duodenal sucrose and glucose infusions enhance suppression by cholecystokinin of sham feeding

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1994.266.2.r466 ◽

1994 ◽

Vol 266 (2) ◽

pp. R466-R471

Author(s):

J. E. Cox

Keyword(s):

Adult Male ◽

Normal Saline ◽

Sprague Dawley ◽

Sham Feeding ◽

Behavioral Observations ◽

Sprague Dawley Rats

In two experiments I examined whether intraduodenal sucrose and glucose would enhance inhibition of sham feeding by cholecystokinin-8 (CCK-8). In the first experiment, adult male Sprague-Dawley rats received infusions of 0.88 M (30%, wt/vol) sucrose or normal saline at 0.51 ml/min for the first 7.67 min of 30-min sham-feeding tests. Tests began 10 min after intraperitoneal injections of saline or 0.5, 1, or 2 micrograms/kg CCK-8. When sucrose was infused, all doses of CCK-8 reduced sham feeding of 0.88 M sucrose by 60% or more, but with saline infusions, only the highest dose was effective. In the second experiment, rats received 30-min infusions of 0.3 M (5.4%) or 0.6 M (10.8%) glucose or equimolar saline at 0.388 ml/min. Although 1 microgram/kg CCK-8 was ineffective in the absence of infusions, it significantly reduced intake in combination with both concentrations of glucose and hypertonic (0.6 M) saline. Behavioral observations indicated that reductions in intake were attributable primarily to decreased meal length and slower intake. These results suggest that an intestinal signal may contribute to the previously reported ability of preloads to potentiate CCK satiety.

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