scholarly journals Association Between Serum High-Molecular-Weight Adiponectin Level and the Severity of Chronic Graft-Versus-Host Disease in Allogeneic Stem Cell Transplantation Recipients

2011 ◽  
Vol 17 (2) ◽  
pp. S338
Author(s):  
H. Nakasone ◽  
P.N.T. Binh ◽  
R. Yamazaki ◽  
Y. Tanaka ◽  
K. Sakamoto ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
High Molecular Weight ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Adiponectin Level ◽  
High Molecular Weight Adiponectin ◽  
Graft Versus Host

Association between serum high-molecular-weight adiponectin level and the severity of chronic graft-versus-host disease in allogeneic stem cell transplantation recipients

Blood ◽  
2011 ◽  
Vol 117 (12) ◽  
pp. 3469-3472 ◽  
Author(s):  
Hideki Nakasone ◽  
Phan Nguyen Thanh Binh ◽  
Rie Yamazaki ◽  
Yukie Tanaka ◽  
Kana Sakamoto ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Critical Role ◽  
Normal Subjects ◽  
High Molecular Weight Adiponectin ◽  
Host Disease ◽  
Graft Versus Host

Abstract Recently, a growing body of evidence has suggested that adiponectin, which is secreted by adipose tissues, plays a critical role in obesity-related and autoimmune diseases. We compared the concentrations of adiponectin among 26 normal subjects and 34 allogeneic stem cell transplantation recipients. The concentrations of adiponectin were significantly higher in recipients with chronic graft-versus-host disease (cGVHD) than those in subjects without cGVHD (21.7 ± 11.0 vs 9.1 ± 6.1 μg/mL in females, P < .001; and 10.1 ± 6.8 vs 4.3 ± 2.9 μg/mL in males, P = .003). Multivariate analysis revealed that a higher concentration of adiponectin was associated with female sex (β-coefficient 8.2, P < .0001) and the severity of cGVHD (β-coefficient 6.6, 12.7, and 15.6, P < .01, each for mild, moderate, and severe cGVHD, respectively). In addition, adiponectin levels increased as cGVHD progressed, decreased as cGVHD improved, and did not change with stable cGVHD. In conclusion, adiponectin was associated with the severity of cGVHD and might play a role in the pathophysiology of cGVHD.

Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation

Blood ◽  
2013 ◽  
Vol 121 (18) ◽  
pp. 3745-3758 ◽  
Author(s):  
Emily Blyth ◽  
Leighton Clancy ◽  
Renee Simms ◽  
Chun K. K. Ma ◽  
Jane Burgess ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Organ Damage ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points

Key Points Infusion of CMV-specific T cells early posttransplant does not increase acute or chronic graft-versus-host disease. CMV-specific T cells early posttransplant reduce the need for pharmacotherapy without increased rates of CMV-related organ damage.

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