Cytotoxicity of the novel anti-cancer drug rViscumin depends on HER-2 levels in SKOV-3 cells

: A facile synthetic protocols were employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for the quality control.

Download Full-text

Assessment of Dihydropyrimidinone based Nanocomposites as Multifunctional Anti-cancer Drug

Materials Advances ◽

10.1039/d1ma00017a ◽

2021 ◽

Author(s):

Thangamani Suppan ◽

Hema Priya Mahendran ◽

Rama Ranjan Bhattacharjee ◽

Sankarganesh Jeyaraj ◽

Kallol Mohanta

Keyword(s):

Quantum Dot ◽

Cancer Drug ◽

The Novel ◽

Carbon Quantum Dot ◽

Anti Cancer ◽

Tumor Inhibitor

Dihydropyrimidinones, a Biginelli compound, have been found to be a tumor inhibitor in the last decade. The novel carbon quantum dot- dihydropyrimidinone (CQD-DHPM) nanocomposites have been prepared by a simple...

Download Full-text

TNBC: A brief discussion on Triple Negative Breast Cancer

International Journal of Advanced Multidisciplinary Research ◽

10.22192/ijamr.2021.08.06.006 ◽

2021 ◽

Vol 8 (6) ◽

pp. 75-82

Author(s):

Dipty Tandi ◽

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Molecular Genetic ◽

Cancer Drug ◽

Female Hormone ◽

Anti Cancer ◽

Drug Treatments ◽

Her 2 ◽

Specific Receptors

TNBC; Triple negative breast cancer is one of the most aggressive type of breast cancer with a high reoccurrence and mortality rate. The reason behind its aggressive type is that TNBC do not have such specific receptors as other cancers. Substantially, Breast tumor cells carries receptors that work as doors for many mechanisms and hormone/enzyme based treatment. These receptors are estrogen (female hormone), Progesterone (female hormone) and HER-2 (Protein; Human epidermal receptor). Absence of these enzymes is result into the less option availability in cancer treatment. To find more possible treatments like chemotherapy, lumpectomy, radiation therapy and other gene therapy we first need to understand the concept behind occurrence and reoccurrence of TNBC. This review listed the possible study of triple negative breast cancer including its appearance in society and the molecular/genetic involvement. It is formerly known that cancer take place due to mutation in BRCA group of genes so it is important to know how it works in the case of TNBC. This study also summarizes the influence of anti-diabetic drug treatment (e.g. metformin) on diabetic cancer patients in order to cancer therapy of TNBC and effect of high glucose concentric cells on anti- cancer drug treatments and strategies for development in TNBC development. Keywords: TNBC; female hormone, breast cancer, BRCA group.

Download Full-text

LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-012-5766-4 ◽

2012 ◽

Vol 403 (1) ◽

pp. 309-321 ◽

Cited By ~ 14

Author(s):

Ján Stariat ◽

Vít Šesták ◽

Kateřina Vávrová ◽

Milan Nobilis ◽

Zuzana Kollárová ◽

...

Keyword(s):

Phase I ◽

Cancer Drug ◽

The Novel ◽

Anti Cancer

Download Full-text

Preparation and Characterization of Novel Anti-cancer drug (s) loaded Co-crystals

Journal of University of Shanghai for Science and Technology ◽

10.51201/jusst/21/09647 ◽

2021 ◽

Vol 23 (09) ◽

pp. 1006-1019

Author(s):

Manju Kharb ◽

◽

Pawan Jalwal ◽

Shikha Rathi ◽

Suresh Kumar ◽

...

Keyword(s):

Pharmacokinetic Profile ◽

Syringic Acid ◽

Cancer Drug ◽

The Novel ◽

Anticancer Chemotherapy ◽

Anti Cancer ◽

Single Method ◽

Vital Component ◽

Viable Approach

Background: Taxanes constitute an important class of anti-cancer agents, which are widely prescribed for the management of cancers like breast, lung and ovaries. These agents belong to Biopharmaceutical Classification System (BCS) class IV, which are neither soluble in the aqueous systems nor permeable across the biological membranes. Objectve: Due to these concerns only, the oral bioavailabilities of these drugs are too low. Looking into these concerns, it was envisaged to develop co-crystals of docetaxel with syringic acid. Methods: For the preparation of co-crystals no single method is used. The methods range from spray drying, crystallization, ultrasonication and freeze drying to supercritical fluid methodologies. Results: The novel co-crystal not only improved the solubility and dissolution rates of the drug, but also resulted in improved pharmacokinetic profile. Conclusion: The present findings provide an economic and viable approach to improve the solubility and absorption profile of a drug, which is a vital component of the anticancer chemotherapy. Such studies provide a hope for the development of approaches to improve the solubility and permeability of drugs with challenges.

Download Full-text

Cancer Chemotherapy by Novel Bio-active Natural Products: Looking Towards the Future

Current Cancer Therapy Reviews ◽

10.2174/1573394714666180321151315 ◽

2019 ◽

Vol 15 (1) ◽

pp. 37-49

Author(s):

Om Prakash ◽

Shazia Usmani ◽

Ruchi Singh ◽

Debarshi K. Mahapatra ◽

Amresh Gupta

Keyword(s):

Clinical Trials ◽

Natural Products ◽

Cancer Drug ◽

The Novel ◽

Current Review ◽

Chronic Disorder ◽

Anti Cancer ◽

The Us ◽

Plant Sources ◽

Active Natural

Background: Cancer is the second leading cause of death globally and accounted for 8.8 million deaths annually in humans. Lung, prostate, colorectal, stomach and liver cancer are the most common types of cancer in men, while breast, colorectal, lung, cervix and stomach cancer are the most common among women. Numerous drugs that the US Food and Drug Administration (FDA) have approved for use in cancer therapy are derived from plants, including taxanes such as paclitaxel and vinca alkaloids such as vincristine and vinblastine. Still, there is an intense need for a search for numerous bioactive sources to develop a novel anti-cancer drug to overcome this chronic disorder. About more than thirty plants derived natural products have been isolated till date and are currently under clinical trials. As per literature survey from various journals and texts has been found to be novel medicinal agents from bioactive sources are clinically active against various types of cancer cells. Conclusion: Current review has been highlighted on the novel medicinal agents from plant sources have potential effects against many types of cancer, which have been supported by clinical trials. The main findings of these active novel medicinal agents were also summarized and discussed here.

Download Full-text