Identification of a nuclear matrix attachment region like sequence in the last intron of PI3Kγ

2006 ◽  
Vol 341 (2) ◽  
pp. 583-590 ◽  
Author(s):  
Bingbing Dai ◽  
Lei Ying ◽  
Rong Cai ◽  
Ying Li ◽  
Xingqian Zhang ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Matrix Attachment Region ◽  
Attachment Region ◽  
Nuclear Matrix Attachment Region

scholarly journals Sequences Adjacent to oriP Improve the Persistence of Epstein-Barr Virus-Based Episomes in B Cells

2001 ◽  
Vol 75 (22) ◽  
pp. 11249-11252 ◽  
Author(s):  
Robert E. White ◽  
Richard Wade-Martins ◽  
Michael R. James
Keyword(s):  
B Cells ◽  
Nuclear Matrix ◽  
Epstein Barr Virus ◽  
Matrix Attachment Region ◽  
Nuclear Antigen ◽  
Adjacent Region ◽  
Barr Virus ◽  
Attachment Region ◽  
Nuclear Matrix Attachment Region ◽  
Epstein Barr

ABSTRACT Epstein-Barr virus (EBV) oriP and the EBV nuclear antigen 1 (EBNA-1) protein allow persistence of EBV-based episomes. A nuclear matrix attachment region (MAR) spansoriP and the adjacent region of the EBV genome containing the EBV-expressed RNAs. Here, we show that episomes with the MAR are retained significantly more efficiently in EBV-positive B cells than episomes containing oriPalone.

scholarly journals Variant Chromatin Structure of theoriP Region of Epstein-Barr Virus and Regulation of EBER1 Expression by Upstream Sequences andoriP

2001 ◽  
Vol 75 (13) ◽  
pp. 6235-6241 ◽  
Author(s):  
Barbara Wensing ◽  
Albert Stühler ◽  
Peter Jenkins ◽  
Martine Hollyoake ◽  
Claudio Elgueta Karstegl ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Virus Genome ◽  
Micrococcal Nuclease ◽  
Matrix Attachment Region ◽  
Barr Virus ◽  
Latently Infected ◽  
Attachment Region ◽  
Nuclear Matrix Attachment Region ◽  
Epstein Barr ◽  
Nucleosomal Structure

ABSTRACT Most of the Epstein-Barr virus genome in latently infected cells is in a standard nucleosomal structure, but the region encompassingoriP and the Epstein-Barr virus-encoded small RNA (EBER) genes shows a distinctive pattern when digested with micrococcal nuclease. This pattern corresponds to a previously mapped nuclear matrix attachment region. Although the EBER genes are adjacent to oriP, there is only a two- to fourfold effect oforiP on EBER expression. However, sequences containing a consensus ATF site upstream of EBER1 are important for EBER1 expression.

Sign in / Sign up

Export Citation Format

Share Document