Identification and characterization of the novel human prostate cancer-specific PC-1 gene promoter

2007 ◽  
Vol 357 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Jian Wang ◽  
Hui Zhang ◽  
Rui-Xia Liang ◽  
Bo Pang ◽  
Qing-Guo Shi ◽  
...  
Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3268
Author(s):  
Katja S. Håheim ◽  
Emil Lindbäck ◽  
Kah Ni Tan ◽  
Marte Albrigtsen ◽  
Ida T. Urdal Helgeland ◽  
...  

A series of novel quinoline-based tetracyclic ring-systems were synthesized and evaluated in vitro for their antiplasmodial, antiproliferative and antimicrobial activities. The novel hydroiodide salts 10 and 21 showed the most promising antiplasmodial inhibition, with compound 10 displaying higher selectivity than the employed standards. The antiproliferative assay revealed novel pyridophenanthridine 4b to be significantly more active against human prostate cancer (IC50 = 24 nM) than Puromycin (IC50 = 270 nM) and Doxorubicin (IC50 = 830 nM), which are used for clinical treatment. Pyridocarbazoles 9 was also moderately effective against all the employed cancer cell lines and moreover showed excellent biofilm inhibition (9a: MBIC = 100 µM; 9b: MBIC = 100 µM).


2009 ◽  
Vol 46 (2) ◽  
pp. 123-130
Author(s):  
Camila B. Piantino ◽  
Juliana M. Sousa-Canavez ◽  
Marta Bellodi-Privato ◽  
Miguel Srougi ◽  
Luiz Heraldo Camara-Lopes ◽  
...  

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Tobias Lange ◽  
Su Jung Oh-Hohenhorst ◽  
Simon A. Joosse ◽  
Klaus Pantel ◽  
Oliver Hahn ◽  
...  

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