The inhibition of Akt-Pdpk1 interaction efficiently suppresses the growth of murine primary liver tumor cells

2016 ◽  
Vol 474 (1) ◽  
pp. 118-125 ◽  
Author(s):  
Kristina Mäemets-Allas ◽  
Denis Belitškin ◽  
Viljar Jaks
Keyword(s):  
Tumor Cells ◽  
Liver Tumor ◽  
Primary Liver Tumor

Effects of (-)-Menthol on Arylamine N-Acetyltransferase Activity in Human Liver Tumor Cells

2001 ◽  
Vol 29 (02) ◽  
pp. 321-329 ◽  
Author(s):  
Jing-Pin Lin ◽  
Yuh-Ching Li ◽  
Weng-Chuan Lin ◽  
Ching-Liang Hsieh ◽  
Jing-Gung Chung
Keyword(s):  
Tumor Cells ◽  
Liver Tumor ◽  
Human Liver ◽  
High Performance ◽  
Time Course ◽  
Tumor Cell Line ◽  
Intact Cells ◽  
Steady State Kinetic ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition

To evaluate whether or not (-)-menthol affects arylamine N-acetyltransferase (NAT) activity, we selected human liver tumor cell line (J 5) for examination. By using high performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene (AF) was determined. (-)-Menthol displayed a dose-dependent inhibition to cytosolic NAT activity. Time-course experiments showed that NAT activity measured from intact human liver tumor cells was inhibited by (-)-menthol for up to 24 hrs. But in human liver tumor intact cells, the low doses (0.0032 and 0.032 mM) of (-)-menthol inhibited NAT activity andthe 0.32 mM (-)-menthol did not show any significant differences between control and (-)-menthol treated groups. Using standard steady-state kinetic analysis, it was demonstrated that (-)-menthol was a possible uncompetitive inhibitor (decrease Km and Vmax) to NAT activity in cytosols. This report is the first demonstration which showed (-)-menthol affect on human liver tumor cells NAT activity.

scholarly journals Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem

Marine Drugs ◽  
2019 ◽  
Vol 17 (7) ◽  
pp. 415 ◽  
Author(s):  
Bolin Jing ◽  
Gong Cheng ◽  
Jianjun Li ◽  
Zhuo A. Wang ◽  
Yuguang Du
Keyword(s):  
Tumor Cells ◽  
Liver Tumor ◽  
Hepg2 Cells ◽  
Tumor Metastasis ◽  
Inhibitory Effect ◽  
Chitosan Oligosaccharide ◽  
Inhibitory Effects ◽  
Tumor Vessel ◽  
Destructive Effect ◽  
Cell Metastasis

Chitooligosaccharides (COS), the only cationic oligosaccharide in nature, have been demonstrated to have anti-tumor activity. However, the inhibitory effects of COS on different stages of tumor metastasis are still unknown, and it is not clear what stage(s) of tumor metastasis COS targeted. To study the inhibitory effects of a new partially acetylated chitooligosaccharide (paCOS) with fraction of acetylation (FA) 0.46 on each phase of liver cancer cell metastasis, a dynamic tumor-vessel microsystem undergoing physiological flow was leveraged. paCOS (FA = 0.46) significantly inhibited proliferation of HepG2 cells through vascular absorption on the chip, and inhibited migration of HepG2 cells by inhibiting the formation of pseudopod in liver tumor cells. It was also found that paCOS at 10 μg/mL had a stronger inhibitory effect on liver tumor cells invading blood vessels than that of paCOS at 100 μg/mL, and paCOS at 100 μg/mL, which had a significant destructive effect on tumor vascular growth and barrier function. Moreover, paCOS reduced the number of liver tumor cells adhering onto the surface of HUVECs layer after 3 h of treatment. Therefore, the results revealed that paCOS had considerable potential as drugs for anti-tumor metastasis.

Primary liver tumor associated with Werner syndrome (adult progeria)

2011 ◽  
Vol 41 (12) ◽  
pp. 1260-1265 ◽  
Author(s):  
Hiroshi Okano ◽  
Yoshiaki Isono ◽  
Hiroki Tanaka ◽  
Yoshiko Ishihara ◽  
Shimpei Matsusaki ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Werner Syndrome ◽  
Primary Liver Tumor

Imaging of single liver tumor cells intoxicated by heavy metals using ToF-SIMS

2006 ◽  
Vol 252 (19) ◽  
pp. 6809-6812 ◽  
Author(s):  
Fu-Der Mai ◽  
Bo-Jung Chen ◽  
Li-Chen Wu ◽  
Feng-Yin Li ◽  
Wen-Kang Chen
Keyword(s):  
Heavy Metals ◽  
Tumor Cells ◽  
Liver Tumor ◽  
Tof Sims

scholarly journals A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells

2014 ◽  
Vol 136 (4) ◽  
pp. E161-E172 ◽  
Author(s):  
Joan Fernando ◽  
Andrea Malfettone ◽  
Edgar B. Cepeda ◽  
Roser Vilarrasa-Blasi ◽  
Esther Bertran ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Liver Tumor ◽  
Apoptotic Response

The effect of overexpressed Daxx in liver tumor cells on the apoptosis induced by oxidative stress

2008 ◽  
Vol 32 (3) ◽  
pp. S34-S35
Author(s):  
Qin Hui Tuo ◽  
Guo Zuo Xiong ◽  
Bing Yang Zhu ◽  
Jian Guo Cao ◽  
Duan Fang Liao
Keyword(s):  
Oxidative Stress ◽  
Tumor Cells ◽  
Liver Tumor

Suppression of tumorigenicity of rat liver tumor cells by human chromosome 13: Evidence against the involvement of pRb and BRCA2

2002 ◽  
Author(s):  
Michelle Rider ◽  
Genelle Butz ◽  
Sharon Ricketts ◽  
Suzanne Newberry ◽  
Joe Grisham ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Tumor Cells ◽  
Rat Liver ◽  
Liver Tumor ◽  
Chromosome 13
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