Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells

2021 ◽  
Vol 534 ◽  
pp. 53-58
Author(s):  
Chia-Chun Chang ◽  
Yi-Chou Liu ◽  
Chih-Hsuan Lin ◽  
Yi-Chun Liao
Keyword(s):  
Cancer Cells ◽  
Histone Acetyltransferase ◽  
Egfr Signaling ◽  
Acetyltransferase P300

scholarly journals Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yi Zhang ◽  
Kyle Brown ◽  
Yucong Yu ◽  
Ziad Ibrahim ◽  
Mohamad Zandian ◽  
...  
Keyword(s):  
Phase Separation ◽  
Cell Nucleus ◽  
Active Site ◽  
Histone Acetyltransferase ◽  
Histone H3 ◽  
Catalytic Core ◽  
Cellular Processes ◽  
Storage Pool ◽  
Core Components ◽  
Acetyltransferase P300

AbstractThe transcriptional co-activator and acetyltransferase p300 is required for fundamental cellular processes, including differentiation and growth. Here, we report that p300 forms phase separated condensates in the cell nucleus. The phase separation ability of p300 is regulated by autoacetylation and relies on its catalytic core components, including the histone acetyltransferase (HAT) domain, the autoinhibition loop, and bromodomain. p300 condensates sequester chromatin components, such as histone H3 tail and DNA, and are amplified through binding of p300 to the nucleosome. The catalytic HAT activity of p300 is decreased due to occlusion of the active site in the phase separated droplets, a large portion of which co-localizes with chromatin regions enriched in H3K27me3. Our findings suggest a model in which p300 condensates can act as a storage pool of the protein with reduced HAT activity, allowing p300 to be compartmentalized and concentrated at poised or repressed chromatin regions.

scholarly journals β1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells

Oncotarget ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 3673-3684 ◽  
Author(s):  
Mei-Ieng Che ◽  
John Huang ◽  
Ji-Shiang Hung ◽  
Yo-Chuen Lin ◽  
Miao-Juei Huang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colon Cancer Cells ◽  
Egfr Signaling ◽  
Cancer Stemness ◽  
Egfr Signaling Pathway

scholarly journals Claudin-3 Overexpression Increases the Malignant Potential of Colorectal Cancer Cells: Roles of ERK1/2 and PI3K-Akt as Modulators of EGFR signaling

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74994 ◽  
Author(s):  
Waldemir F. de Souza ◽  
Natalia Fortunato-Miranda ◽  
Bruno K. Robbs ◽  
Wallace M. de Araujo ◽  
Julio C. de-Freitas-Junior ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Malignant Potential ◽  
Egfr Signaling ◽  
Colorectal Cancer Cells

scholarly journals The histone acetyltransferase p300 promotes intrinsic axonal regeneration

Brain ◽  
2011 ◽  
Vol 134 (7) ◽  
pp. 2134-2148 ◽  
Author(s):  
Perrine Gaub ◽  
Yashashree Joshi ◽  
Anja Wuttke ◽  
Ulrike Naumann ◽  
Sven Schnichels ◽  
...  
Keyword(s):  
Axonal Regeneration ◽  
Histone Acetyltransferase ◽  
Acetyltransferase P300

Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation

Tumor Biology ◽  
2014 ◽  
Vol 36 (2) ◽  
pp. 1129-1133 ◽  
Author(s):  
Yongsheng Jiang ◽  
Shaochuan Sun ◽  
Guoqin Liu ◽  
Bing Yan ◽  
Jun Niu
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Egfr Signaling ◽  
Colorectal Cancer Cells
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