IL-10 gene polymorphism and influence of chemotherapy on cytokine plasma levels in childhood acute lymphoblastic leukemia patients

2015 ◽  
Vol 55 (2) ◽  
pp. 168-172 ◽  
Author(s):  
Carlos Hiroji Hiroki ◽  
Marla Karine Amarante ◽  
Diego Lima Petenuci ◽  
Alberto Yoichi Sakaguchi ◽  
Fausto Celso Trigo ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gene Polymorphism ◽  
Plasma Levels ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cytokine Plasma

MDR1 C3435 Gene Polymorphism in Adult and Childhood Acute Lymphoblastic Leukemia of an Ethnic Iranian Population

2010 ◽  
Vol 10 (3) ◽  
pp. E30
Author(s):  
Behnoush Miladpour ◽  
Amireh Nejat Shokouhi ◽  
Abbas Shirdel ◽  
Abdollah Banihashem ◽  
Habibollah Esmaeili ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gene Polymorphism ◽  
Lymphoblastic Leukemia ◽  
Iranian Population ◽  
Childhood Acute Lymphoblastic Leukemia

scholarly journals Assocition between LAPTM4B gene polymorphism and the risk of childhood acute lymphoblastic leukemia

2020 ◽  
Vol 22 (1) ◽  
pp. 67-70
Author(s):  
Gholamreza Bahari ◽  
Mohammad Hashemi ◽  
Mohsen Taheri ◽  
Majid Naderi ◽  
◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gene Polymorphism ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia

Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia

Blood ◽  
2002 ◽  
Vol 100 (10) ◽  
pp. 3832-3834 ◽  
Author(s):  
Caroline Laverdière ◽  
Sonia Chiasson ◽  
Irina Costea ◽  
Albert Moghrabi ◽  
Maja Krajinovic
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Plasma Levels ◽  
Lymphoblastic Leukemia ◽  
Underlying Mechanism ◽  
The Other ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Reduced Folate Carrier ◽  
Event Free Survival ◽  
Childhood All ◽  
Free Survival

Methotrexate (MTX) is a key compound of chemotherapeutic regimens used in the treatment of childhood acute lymphoblastic leukemia (ALL). Resistance to this drug may arise by, among other factors, altered cellular uptake that may hamper the efficacy of the treatment. Recently, a G80A polymorphism has been described in the reduced folate carrier gene (RFC1), which encodes the major MTX transporter. Here, we assessed the association between the genetic polymorphisms G80A and both MTX plasma levels and childhood ALL outcome. Children with the A80 variant had worse prognoses than patients with the GG genotype (P = .04), as shown by event-free survival estimates. Patients homozygous for A80 had higher levels of MTX (P = .004) than the other genotype groups. Possible explanations for observed associations are discussed; however, additional experiments are required to achieve understanding of the underlying mechanism.

scholarly journals MTHFR C677T and TS 5’-UTR 3R/3R Gene Polymorphism in Methotrexate-Resistant Childhood Acute Lymphoblastic Leukemia

2020 ◽  
Vol 12 (2) ◽  
pp. 177-82
Author(s):  
I Dewa Gede Ugrasena ◽  
Harianto Notopuro ◽  
Subijanto Marto Sudarmo ◽  
Ketut Sudiana ◽  
Djajadiman Gatot ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gene Polymorphism ◽  
Lymphoblastic Leukemia ◽  
Dominant Gene ◽  
Mthfr C677t ◽  
Folate Metabolism ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Childhood All ◽  
Pcr Rflp ◽  
Ts Polymorphism

BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy in Indonesia and often treated by methotrexate (MTX). Though it can be cured in 30-60% of patients, MTX resistance remains the major cause of treatment failure in childhood ALL. Previous sudies showed that its anti-leukemic property was moderated by MTX ability to inhibitmethylene tetra hydrofolate reductase (MTHFR) and thymidylate synthase (TS) in folate metabolism. This study investigates the correlation between MTHFR and TS polymorphism and MTX resistance in ALL children.METHODS: A total of 155 subjects obtained from all subjects prior to chemotherapy. DNA from blood samples were extracted and underwent polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) to evaluate MTHFR C677T and TS 5’-UTR 3R/3R polymorphism.RESULTS: There was significant correlation between MTHFR C677T and TS 5’-UTR 3R/3R gene polymorphism with MTX resistance. Subjectswith MTHFR C677T and TS 5’-UTR 3R/3R gene polymorphism were 4 times (p=0.007) and 6.4 times (p=0.001) more likely to be MTX resistant than those without gene polymorphisms, respectively.CONCLUSION: MTHFR C677T andTS 5’-UTR 3R/3R represent dominant gene polymorphism related to MTX resistance in childhood ALL.KEYWORDS: gene polymorphism, folate metabolism, acute lymphoblastic leukemia

scholarly journals Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia

2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Alinne Rivas‑alarcón ◽  
Yazmin Gómez‑gómez ◽  
Jorge Organista‑nava ◽  
Marco Jiménez‑lópez ◽  
Ana Rivera‑ramírez ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Prognostic Factor ◽  
Plasma Levels ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia
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