Primary gonadal failure

2019 ◽  
Vol 33 (3) ◽  
pp. 101295 ◽  
Author(s):  
Asmahane Ladjouze ◽  
Malcolm Donaldson
Keyword(s):  
Primary Gonadal Failure ◽  
Gonadal Failure

Minichromosome maintenance complex component 8 (MCM8) gene mutations result in primary gonadal failure

2015 ◽  
Vol 52 (6) ◽  
pp. 391-399 ◽  
Author(s):  
Yardena Tenenbaum-Rakover ◽  
Ariella Weinberg-Shukron ◽  
Paul Renbaum ◽  
Orit Lobel ◽  
Hasan Eideh ◽  
...  
Keyword(s):  
Gene Mutations ◽  
Minichromosome Maintenance ◽  
Complex Component ◽  
Primary Gonadal Failure ◽  
Gonadal Failure

A Simplified Radioimmunoassay for Human Pituitary Luteinizing Hormone in Serum

1971 ◽  
Vol 17 (9) ◽  
pp. 931-935 ◽  
Author(s):  
Robert A Levine ◽  
Richard K Donabedian ◽  
Luis G Sobrinho
Keyword(s):  
Luteinizing Hormone ◽  
Follicular Phase ◽  
Serum Concentrations ◽  
Human Pituitary ◽  
Clinical Diagnoses ◽  
Normal Males ◽  
Primary Gonadal Failure ◽  
Gonadal Failure

Abstract A simplified radioimmunoassay is described for human pituitary luteinizing hormone (LH). The principal modification over existing methods is that talc is used to separate antibody-bound hormone from free hormone by adsorption of the latter. Serum concentrations of LH in normal males, ovulatory females (follicular phase), postmenopausal females, patients with primary gonadal failure, and patients with hypopituitarism averaged 4.7, 4.6, 26.4, 30.8, and 1.9 µg of reference std. LER 907 per 100 ml of serum, respectively (10.3, 10.1, 57.8, 67.5, 4.2 milli-int. units/ml, respectively). These values are consistent with the clinical diagnoses.

CANDIDIASIS: STUDIES PERTAINING TO ITS ASSOCIATION WITH ENDOCRINOPATHIES AND PERNICIOUS ANEMIA

PEDIATRICS ◽  
1968 ◽  
Vol 42 (2) ◽  
pp. 231-237
Author(s):  
R. M. Blizzard ◽  
J. H. Gibbs
Keyword(s):  
Gastric Mucosa ◽  
Pernicious Anemia ◽  
Adrenal Cortex ◽  
Specific Antibodies ◽  
Associated Diseases ◽  
Subclinical Disease ◽  
Group I ◽  
Mucous Membranes ◽  
Primary Gonadal Failure ◽  
Gonadal Failure

Forty-four patients with chronic or recurrent candidiasis of the dermis, mucous membranes, or both, have been studied in relation to associated diseases. Thirty-one patients (Group I) had at least one associated disease. Thirteen (Group II) had only candidiasis. Neonates with oral moniliasis, children with chronic debilitation, and children receiving antibiotics were eliminated from the study. Idiopathic hypoparathyroidism was the most common associated disease of the patients in Group I (26 of 31 patients). Addison's disease also was common (14 of 31 patients). Hypothyroidism, alopecia, cirrhosis, pernicious anemia, and primary gonadal failure also occurred. Evidence for subclinical disease of the thyroid, adrenal cortex, and gastric mucosa, as reflected by tissue specific antibodies, was common in patients with candidiasis. Anti-kidney antibodies also were found in 18 patients, but their significance is unclear. No etiological relationship between the candidiasis and the associated diseases could be demonstrated.

Congenital fusion of the fourth and fifth metacarpals associated with primary gonadal failure

1996 ◽  
Vol 25 (3) ◽  
pp. 269-271 ◽  
Author(s):  
William D. Donovan ◽  
P. W. Brill ◽  
Patricia Winchester ◽  
Philip F. Giampietro ◽  
Jessica G. Davis ◽  
...  
Keyword(s):  
Congenital Fusion ◽  
Primary Gonadal Failure ◽  
Gonadal Failure

Combined FSH and LH secreting pituitary adenoma in a young fertile woman without primary gonadal failure

1986 ◽  
Vol 112 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Nora Moses ◽  
Victoria Goldberg ◽  
Raúl Gutman ◽  
Darío Cácamo
Keyword(s):  
Pituitary Adenoma ◽  
Transsphenoidal Surgery ◽  
Pituitary Tumour ◽  
Serum Prolactin ◽  
Fertile Woman ◽  
Basal Serum ◽  
History Of ◽  
Primary Gonadal Failure ◽  
Peak Value ◽  
Gonadal Failure

Abstract. A 28 year old fertile woman presented with a history of amenorrhoea and galactorrhoea, and an enlarged pitutiary fossa. Serum FSH and LH were repeatedly elevated both basally (32 and 44 mIU/ml) and after LRH (peak values, 108 and 420 mIU/ml). One mg of oestradiol (E2) benzoate im daily for 5 days failed to lower basal or LRH-stimulated serum gonadotrophins. Serum E2 was 170 pg/ml, basal serum prolactin (Prl) was 30 ng/ml and responded briskly to TRH (peak value 103 ng/ml). An 0.8 × 0.8 cm tumour was selectively excised by transsphenoidal surgery. Menses reappeared soon afterwards accompanied by normalization of serum FSH and LH plus biochemical evidence of ovulation. Specific immunostaining of tumoural cells was achieved with either FSH or LH antiserum, and adequate suppression of staining was obtained after preabsorbing each antiserum with and excess of its respective antigen. Our patient appears to be the first documented female with a combined FSH and LH producing pituitary tumour and no prior evidence of primary gonadal failure.

Wolfram syndrome: clinical and genetic profiling of a cohort from a tertiary care centre with characterization of the primary gonadal failure

Endocrine ◽  
2020 ◽  
Vol 69 (2) ◽  
pp. 420-429
Author(s):  
Liza Das ◽  
Ashutosh Rai ◽  
Ravimohan Mavuduru ◽  
Kim Vaiphei ◽  
Akhilesh Sharma ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Wolfram Syndrome ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Genetic Profiling ◽  
Primary Gonadal Failure ◽  
Gonadal Failure

Plasma LRH levels in chronic renal failure before and during haemodialysis

1983 ◽  
Vol 103 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Miyao Matsubara ◽  
Koji Nakagawa ◽  
Katsuya Nonomura ◽  
Noriaki Hirota
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Plasma Proteins ◽  
Feedback Inhibition ◽  
Displacement Curve ◽  
Basal Plasma ◽  
Male Patients ◽  
High Concentrations ◽  
Primary Gonadal Failure ◽  
Gonadal Failure

Abstract. Endogenous immunoreactive luteinizing hormone – releasing hormone (LRH) in plasma was determined in 6 male and 7 female patients with chronic renal failure before and during haemodialysis. Basal plasma LRH levels ranged from 5.8 to 23.0 pg/ml and, in 11 out of 13 patients, were above the levels seen in healthy subjects (less than 7 pg/ml for men and less than 8 pg/ml for women). This immunoreactivity was eluted in identical fractions with synthetic LRH and plasma extracts from climacteric women on Sephadex G-25 chromatography, and the dilution gave a displacement curve parallel to the standard. Within 5 h of haemodialysis, these high LRH levels declined into the normal range. The concentraions of LH in plasma in these patients were also elevated, but those of testosterone in male patients were decreased. These results suggest 1) that elevated plasma LRH reflects decreased feedback inhibition by primary gonadal failure and might in turn be responsible at least in part for high concentrations of plasma LH in chronic renal failure, and 2) that plasma LRH is mainly not bound to plasma proteins.

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