The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration

BACKGROUND: Checkpoint inhibitors and receptor tyrosine kinase inhibitors (RTKIs) have changed the standard of care for metastatic renal cell carcinoma (mRCC). Anecdotal evidence suggests these therapies may be less effective for treating bone than soft-tissue metastases. PURPOSE: We performed a retrospective review evaluating the relative clinical responses in soft-tissue and bone metastases in patients undergoing therapy using RTKIs and anti-programmed death-1 (PD-1) agents for mRCC. METHODS: Of the 2,212 patients in our institutional cancer registry with renal cell carcinoma (1997–2017), 68 (82 disease courses) were identified with measurable bone and soft-tissue metastases treated with RTKIs and/or PD-1s. Extent of metastasis was quantified at the time of therapy initiation (baseline) and at 3 months, 6 months, and 1 year. Changes in disease status were categorized as complete response, partial response, stable, mixed, or progression of disease according to RECIST v1.1 and MD Anderson criteria. These categories were further organized into “response to treatment” or “evidence of progression” to generate a generalized linear effects model with soft-tissue response as the independent variable and bone response as the dependent variable. Alpha = 0.05. RESULTS: Soft-tissue response correlated with bone response at 3 months (76 disease courses, p = 0.005) and 6 months (48 disease courses, p = 0.017). Of the patients with controlled soft-tissue disease, only 14 (19%) and 15 (32%) had progression in bone at 3 and 6 months, respectively. CONCLUSION: Contrary to anecdotal reports, osseous metastases do not appear to respond worse than soft-tissue metastases to treatment with these agents.

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Flame Retardancy and Thermal Degradation Behavior of Epoxy Resin Treated with a Phosphorus and Silicon containing Compound

JOURNAL OF POLYMER MATERIALS ◽

10.32381/jpm.2018.35.03.7 ◽

2019 ◽

Vol 35 (3) ◽

pp. 329-340 ◽

Cited By ~ 1

Author(s):

YI CHEN ◽

◽

WENQIN HE ◽

SHIQI CHEN ◽

JIANGBO WANG ◽

...

Keyword(s):

Thermal Degradation ◽

Epoxy Resin ◽

Flame Retardancy ◽

Degradation Behavior ◽

Thermal Degradation Behavior

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Degradation Behavior of TiN Coatings with Different Thicknesses after a Pulsed Laser Thermal Shock Test

Korean Journal of Metals and Materials ◽

10.3365/kjmm.2013.51.10.729 ◽

2013 ◽

Vol 51 (10) ◽

pp. 729-734 ◽

Cited By ~ 1

Author(s):

Seol Jeon ◽

Youngkue Choi ◽

Hyun-Gyoo Shin ◽

Hyun Park ◽

Heesoo Lee ◽

...

Keyword(s):

Thermal Shock ◽

Pulsed Laser ◽

Thermal Shock Test ◽

Degradation Behavior ◽

Shock Test ◽

Tin Coatings

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Short term mechanical stimulation using whole body vibration identifies differences in bone response between prepubertal boys with and without prior fracture

Bone Abstracts ◽

10.1530/boneabs.7.p25 ◽

2019 ◽

Author(s):

Rachel Harrison ◽

Kate Ward ◽

Alan Rigby ◽

Fatma Gossiel ◽

Nick Bishop

Keyword(s):

Mechanical Stimulation ◽

Whole Body Vibration ◽

Whole Body ◽

Short Term ◽

Body Vibration ◽

Bone Response ◽

Prior Fracture ◽

Prepubertal Boys

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Ultra-trail marathon induces bone response in association with acute and established metabolic changes

Endocrine Abstracts ◽

10.1530/endoabs.41.oc11.3 ◽

2016 ◽

Author(s):

Giovanni Lombardi ◽

Veronica Sansoni ◽

Silvia Perego ◽

Gianluca Vernillo ◽

Federico Schena ◽

...

Keyword(s):

Metabolic Changes ◽

Bone Response

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Influence of Bone Quality, Drilling Protocol, Implant Diameter/Length on Primary Stability: An In Vitro Comparative Study on Insertion Torque and Resonance Frequency Analysis

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00145 ◽

2020 ◽

Vol 46 (3) ◽

pp. 182-189 ◽

Cited By ~ 1

Author(s):

Davide Farronato ◽

Mattia Manfredini ◽

Michele Stocchero ◽

Mattia Caccia ◽

Lorenzo Azzi ◽

...

Keyword(s):

Resonance Frequency ◽

Bone Quality ◽

Frequency Analysis ◽

Primary Stability ◽

Mean Difference ◽

Insertion Torque ◽

Resonance Frequency Analysis ◽

Bone Response ◽

Implant Length

The aim of this study was to evaluate the influence of bone quality, drilling technique, implant diameter, and implant length on insertion torque (IT) and resonance frequency analysis (RFA) of a prototype-tapered implant with knife-edge threads. The investigators hypothesized that IT would be affected by variations in bone quality and drilling protocol, whereas RFA would be less influenced by such variables. The investigators implemented an in vitro experiment in which a prototype implant was inserted with different testing conditions into rigid polyurethane foam blocks. The independent variables were: bone quality, drilling protocol, implant diameter, and implant length. Group A implants were inserted with a conventional drilling protocol, whereas Group B implants were inserted with an undersized drilling protocol. Values of IT and RFA were measured at implant installation. IT and RFA values were significantly correlated (Pearson correlation coefficient: 0.54). A multivariable analysis showed a strong model. Higher IT values were associated with drilling protocol B vs A (mean difference: 71.7 Ncm), implant length (3.6 Ncm increase per mm in length), and substrate density (0.199 Ncm increase per mg/cm3 in density). Higher RFA values were associated with drilling protocol B vs A (mean difference: 3.9), implant length (1.0 increase per mm in length), and substrate density (0.032 increase per mg/cm3 in density). Implant diameter was not associated with RFA or IT. Within the limitations of an in vitro study, the results of this study suggest that the studied implant can achieve good level of primary stability in terms of IT and RFA. A strong correlation was found between values of IT and RFA. Both parameters are influenced by the drilling protocol, implant length, and substrate density. Further studies are required to investigate the clinical response in primary stability and marginal bone response.

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