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Quorum sensing is defined as cell to cell communication between microorganisms, which enables
microorganisms to behave as multicellular organisms. Quorum sensing enables many collaborative benefits such as
synchronisation of virulence factors and biofilm formation. Both quorum sensing as well as biofilm formation encourage
the development of drug resistance in microorganisms. Biofilm formation and quorum sensing are causally linked to each
other and play role in the pathogenesis of microorganisms. With the increasing drug resistance against the available
antibiotics and antifungal medications, scientists are combining different options to develop new strategies. Such strategies
rely on the inhibition of the communication and virulence factors rather than on killing or inhibiting the growth of the
microorganisms. This review encompasses the communication technique used by microorganisms, how microorganism
resistance is linked to quorum sensing and various chemical strategies to combat quorum sensing and thereby drug
resistance. Several compounds have been identified as quorum sensing inhibitors and are known to be effective in reducing
resistance as they do not kill the pathogens but rather disrupt their communication. Natural compounds have been identified
as anti-quorum sensing agents. However, natural compounds present several related disadvantages. Therefore, the need for
the development of synthetic or semi-synthetic compounds has arisen. This review argues that anti-quorum sensing
compounds are effective in disrupting quorum sensing and could therefore be effective in reducing microorganism drug
resistance.
SELECTED PHYTOCHEMICAL BIOACTIVE COMPOUNDS AS QUORUM SENSING INHIBITORS
