In vivo degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds

Biomaterials ◽  
2005 ◽  
Vol 26 (22) ◽  
pp. 4616-4623 ◽  
Author(s):  
Elizabeth L. Hedberg ◽  
Henriette C. Kroese-Deutman ◽  
Charles K. Shih ◽  
Roger S. Crowther ◽  
Darrell H. Carney ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Composite Scaffolds ◽  
Poly Propylene ◽  
In Vivo Degradation ◽  
Porous Poly

In vitro degradation of porous poly(propylene fumarate)/poly(dl-lactic-co-glycolic acid) composite scaffolds

Biomaterials ◽  
2005 ◽  
Vol 26 (16) ◽  
pp. 3215-3225 ◽  
Author(s):  
Elizabeth L. Hedberg ◽  
Charles K. Shih ◽  
Jeremy J. Lemoine ◽  
Mark D. Timmer ◽  
Michael A. K. Liebschner ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Composite Scaffolds ◽  
In Vitro Degradation ◽  
Poly Propylene ◽  
Porous Poly

In vitro and in vivo degradation of porous poly(dl-lactic-co-glycolic acid) foams

Biomaterials ◽  
2000 ◽  
Vol 21 (18) ◽  
pp. 1837-1845 ◽  
Author(s):  
Lichun Lu ◽  
Susan J Peter ◽  
Michelle D. Lyman ◽  
Hui-Lin Lai ◽  
Susan M Leite ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
In Vivo Degradation ◽  
Porous Poly

IN VITRO AND IN VIVO DEGRADATION OF A TWISTED SILK FIBROIN–POLY(LACTIC-CO-GLYCOLIC ACID) FIBER COMPOSITE ROPE-LIKE SCAFFOLD AND CHANGES IN ITS MECHANICAL PROPERTIES

2016 ◽  
Vol 16 (04) ◽  
pp. 1650053
Author(s):  
WENYUAN ZHANG ◽  
YADONG YANG ◽  
KEJI ZHANG ◽  
YING LI ◽  
GUOJIAN FANG
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Tissue Engineering ◽  
Mass Loss ◽  
Silk Fibroin ◽  
Glycolic Acid ◽  
Property Loss ◽  
In Vivo Degradation

Natural silk fibroin fiber is slowly degraded, which makes it difficult to be replaced quickly by regenerating tissues of tissue engineering. We used poly(lactic-co-glycolic acid) (PLGA, lactic acid:glycolic acid [Formula: see text] 10:90) fibers to adjust the overall degradation rate of the scaffolds. This study fabricated a three-strand helical composite rope-like scaffold from silk fibroin and PLGA fibers (silk fibroin:PLGA [Formula: see text] 36:64) using a twisting method. In vitro and in vivo degradation experiments were performed over 16 weeks. Results suggest that the in vitro and in vivo degradation tendencies of the scaffold were similar, with mass loss lagging behind mechanical property loss. The speed of degradation in vivo was faster than that in vitro. Mechanical property loss of the scaffold was fast during the first three weeks, when mass loss was slow. Mass loss rate accelerated from weeks 3 to 8. The mass and mechanical properties were relatively stable from 8 to 16 weeks. After 16 weeks of degradation, the scaffold still had considerably strong mechanical properties. The scaffold showed a reasonable and suitable degradation speed with good histocompatibility for ligament tissue engineering.

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