In vitro degradation of porous poly(propylene fumarate)/poly(dl-lactic-co-glycolic acid) composite scaffolds

Biomaterials ◽  
2005 ◽  
Vol 26 (16) ◽  
pp. 3215-3225 ◽  
Author(s):  
Elizabeth L. Hedberg ◽  
Charles K. Shih ◽  
Jeremy J. Lemoine ◽  
Mark D. Timmer ◽  
Michael A. K. Liebschner ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Composite Scaffolds ◽  
In Vitro Degradation ◽  
Poly Propylene ◽  
Porous Poly

In vitro degradation and fracture toughness of multilayered porous poly(propylene fumarate)/?-tricalcium phosphate scaffolds

2002 ◽  
Vol 61 (1) ◽  
pp. 159-164 ◽  
Author(s):  
Michael S. Wolfe ◽  
David Dean ◽  
Jeffrey E. Chen ◽  
John P. Fisher ◽  
Seungho Han ◽  
...  
Keyword(s):  
Fracture Toughness ◽  
Tricalcium Phosphate ◽  
In Vitro Degradation ◽  
Poly Propylene ◽  
Porous Poly

In vivo degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds

Biomaterials ◽  
2005 ◽  
Vol 26 (22) ◽  
pp. 4616-4623 ◽  
Author(s):  
Elizabeth L. Hedberg ◽  
Henriette C. Kroese-Deutman ◽  
Charles K. Shih ◽  
Roger S. Crowther ◽  
Darrell H. Carney ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Composite Scaffolds ◽  
Poly Propylene ◽  
In Vivo Degradation ◽  
Porous Poly

scholarly journals 3D Plotting using Camphene as Pore-regulating Agent to Produce Hierarchical Macro/micro-porous Poly(ε-caprolactone)/calcium phosphate Composite Scaffolds

Materials ◽  
2019 ◽  
Vol 12 (17) ◽  
pp. 2650
Author(s):  
Jae-Won Choi ◽  
Woo-Youl Maeng ◽  
Young-Hag Koh ◽  
Hyun Lee ◽  
Hyoun-Ee Kim
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Phase Separation ◽  
Calcium Phosphate ◽  
Tensile Modulus ◽  
Compressive Modulus ◽  
Composite Scaffolds ◽  
In Vitro Biocompatibility ◽  
Porous Poly

This study demonstrates the utility of camphene as the pore-regulating agent for phase separation-based 3D plotting to produce hierarchical macro/micro-porous poly(ε-caprolactone) (PCL)–calcium phosphate (CaP) composite scaffolds, specifically featuring highly microporous surfaces. Unlike conventional particulate porogens, camphene is highly soluble in acetone, the solvent for PCL polymer, but insoluble in coagulation medium (water). In this study, this unique characteristic supported the creation of numerous micropores both within and at the surfaces of PCL and PCL–CaP composite filaments when using high camphene contents (40 and 50 wt%). In addition, the incorporation of the CaP particles into PCL solutions did not deteriorate the formation of microporous structures, and thus hierarchical macro/micro-porous PCL–CaP composite scaffolds could be successfully produced. As the CaP content increased, the in vitro biocompatibility, apatite-forming ability, and mechanical properties (tensile strength, tensile modulus, and compressive modulus) of the PCL–CaP composite scaffolds were substantially improved.

In vitro degradation of porous poly(lactic acid)/quantum dots scaffolds

2013 ◽  
Vol 55 ◽  
pp. 234-239 ◽  
Author(s):  
Xinghou Gong ◽  
Chak Yin Tang ◽  
Ling Pan ◽  
Zhonghua Hao ◽  
Chi Pong Tsui ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Lactic Acid ◽  
Poly Lactic Acid ◽  
In Vitro Degradation ◽  
Porous Poly

In Vitro Degradation of Poly(lactic-co2-glycolic) Acid Random Copolymers

2007 ◽  
Vol 251 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Elisabeth Vey ◽  
Aline F. Miller ◽  
Mike Claybourn ◽  
Alberto Saiani
Keyword(s):  
Glycolic Acid ◽  
Random Copolymers ◽  
In Vitro Degradation

In vitro degradation and bioactivity of poly(propylene fumarate)/bioactive glass sintered microsphere scaffolds for bone tissue engineering

2016 ◽  
Vol 23 (3) ◽  
pp. 245-256 ◽  
Author(s):  
Sima Shahabi ◽  
Yashar Rezaei ◽  
Fathollah Moztarzadeh ◽  
Farhood Najafi
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
P Uptake ◽  
Surface Reactivity ◽  
Ion Concentration ◽  
Composite Scaffolds ◽  
Poly Propylene

AbstractWe developed degradable poly(propylene fumarate)/bioactive glass (PPF/BG) composite scaffolds based on a sintered microsphere technique and investigated the effects of BG content on the characteristics of these composite scaffolds. Immersion in a simulated body fluid (SBF) was used to evaluate the surface reactivity of composite scaffolds. The surface of composite scaffolds was covered with hydroxycarbonate apatite layer after 7 days of immersion. Ion concentration analyses revealed a decrease in P concentration and an increase in Si, Ca, and Sr concentrations in SBF immersed with composite scaffolds during the 3-week period. The Ca and P uptake rates decreased after 4 days of incubation. This coincided with the decrease of the Si release rate. These data lend support to the suggestion that the Si released from the BG content of scaffolds present in the polymer matrix was involved in the formation of the Ca-P layer. The evaluation of the in vitro degradation of composite microspheres revealed that the weight of scaffolds remained relatively constant during the first 3 weeks and then started to decrease slowly, losing 10.5% of their initial mass by week 12. Our results support the concept that these new bioactive, degradable composite scaffolds may be used for bone tissue engineering applications.

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