Conduits harnessing spatially controlled cell-secreted neurotrophic factors improve peripheral nerve regeneration

Biomaterials ◽  
2019 ◽  
Vol 203 ◽  
pp. 86-95 ◽  
Author(s):  
Aaron X. Sun ◽  
Travis A. Prest ◽  
John R. Fowler ◽  
Rachel M. Brick ◽  
Kelsey M. Gloss ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Neurotrophic Factors ◽  
Peripheral Nerve Regeneration

scholarly journals PERIPHERAL NERVE REGENERATION: CELL THERAPY AND NEUROTROPHIC FACTORS

2011 ◽  
Vol 46 (6) ◽  
pp. 643-649 ◽  
Author(s):  
Alessandra Deise Sebben ◽  
Martina Lichtenfels ◽  
Jefferson Luis Braga da Silva
Keyword(s):  
Cell Therapy ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Neurotrophic Factors ◽  
Peripheral Nerve Regeneration

Tissue Engineering Scaffold Slowly Releasing Neurotrophic Factors to Bridge Long Peripheral Nerve Defect

2022 ◽  
Vol 12 (2) ◽  
pp. 329-334
Author(s):  
Jie Dai ◽  
Maimaitiaili Niyazi ◽  
Jiang Xie
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Neurotrophic Factors ◽  
Peripheral Nerve Regeneration ◽  
Physiological Saline ◽  
Negative Control Group ◽  
Negative Control ◽  
Neural Regeneration ◽  
Control Group ◽  
Release System

Consistent application of neurotropic factors is necessary in peripheral nerve regeneration, yet challenging to achieve. Here we used a novel neurotropic factor controlled release system consisted of fibrin, fibronectin and hydrogel to slowly release two neurotrophic factors. At the same time, physiological saline and reverse nerve suturing were used as negative and positive control. A year after surgery, animals which were treated by neurotrophic factor slow release system achieved far better neural regeneration and myelination, as well as superior recovery of hindfoot than the negative control group. In the meanwhile, the results in the experimental group are still inferior to the nerve allograft group. In can be concluded from those results that, consistent releasing of neurotrophic factors can significantly promote long peripheral nerve regeneration, but still short of achieving the results same as the gold standard of autologous nerve grafting.

scholarly journals Neurotrophic factors combined with stem cells in the treatment of sciatic nerve injury in rats:a meta-analysis

2021 ◽  
Author(s):  
Kuangpin Liu ◽  
Wei Ma ◽  
Chun-Yan Li ◽  
Li-Yan Li
Keyword(s):  
Stem Cells ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Neurotrophic Factors ◽  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Peripheral Nerve Regeneration ◽  
Sciatic Nerve Injury

Treatment of peripheral nerve regeneration with stem cells alone has some limitations. For this reason, we evaluate the efficacy of neurotrophic factors combined with stem cell transplantation in the treatment of sciatic nerve injury in rats. PubMed, Cochrane Library, EMbase, WanFang, VIP and China National Knowledge Infrastructure databases were retrieved from inception to October 2021, and control experiments on neurotrophic factors combined with stem cells in the treatment of sciatic nerve injury in rats were searched. Nine articles and 551 rats were included in the meta-analysis. The results of meta-analysis confirmed that neurotrophic factor combined with stem cells for the treatment of sciatic nerve injury yielded more effective repair than normal rats with regard to sciatic nerve index, electrophysiological detection index, electron microscope observation index, and recovery rate of muscle wet weight. The conclusion is that neurotrophic factor combined with stem cells is more conducive to peripheral nerve regeneration and functional recovery than stem cells alone. However, due to the limitation of the quality of the included literature, the above conclusions need to be verified by randomized controlled experiments with higher quality and larger samples.

Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective

2020 ◽  
Vol 25 (4) ◽  
pp. 320-334
Author(s):  
Brian V. Lien ◽  
Nolan J. Brown ◽  
Seth C. Ransom ◽  
Brandon M. Lehrich ◽  
Shane Shahrestani ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Neurotrophic Factors ◽  
Basic Science ◽  
Peripheral Nerve Regeneration ◽  
Clinical Perspective
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