PERIPHERAL NERVE REGENERATION: CELL THERAPY AND NEUROTROPHIC FACTORS

In Ukraine, 2,500–3,000 people sustain peripheral nerve injuries every year. Often these are young people of working age. In the structure of total injuries, peripheral nerve damage in peacetime makes 1.5–6%, and during military operations (taking into account the situation in the east of Ukraine), this value ranges from 9 to 25% due to gunshot injuries. Analysis of medical literature and publications over the past five years was carried out, with due attention to the studies related to modern surgical treatment methods of peripheral nerve traumatic injuries. The problem of surgical treatment has not been thoroughly studied. Peripheral nerve regeneration is a complex process, and therefore the existing treatment methods are limited due to slow nerve regeneration and insufficient spanning of large post-traumatic nerve defects. To overcome these limitations, a cell therapy has been developed that ensures the presence of supporting cells at the site of the lesion in order to accelerate nerve regeneration. Schwann cells play an important role in many aspects of nerve regeneration. Stem cell transplantation for peripheral nerve regeneration represents alternative cell therapy with several regenerative benefits. Various types of stem cell sources are currently being investigated for use for peripheral nerve regeneration in combination with the most optimal nerve guide conduit.

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Role of Neurotrophic Factors in Peripheral Nerve Regeneration

Peripheral Nerve Lesions ◽

10.1007/978-3-642-75611-5_5 ◽

1990 ◽

pp. 29-31 ◽

Cited By ~ 2

Author(s):

D. Lindholm ◽

H. Thoenen

Keyword(s):

Peripheral Nerve ◽

Nerve Regeneration ◽

Neurotrophic Factors ◽

Peripheral Nerve Regeneration

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Peripheral nerve regeneration and neurotrophic factors

Journal of Anatomy ◽

10.1046/j.1469-7580.1999.19410001.x ◽

1999 ◽

Vol 194 (1) ◽

pp. 1-14 ◽

Cited By ~ 437

Author(s):

GIORGIO TERENGHI

Keyword(s):

Peripheral Nerve ◽

Nerve Regeneration ◽

Neurotrophic Factors ◽

Peripheral Nerve Regeneration

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Tissue Engineering Scaffold Slowly Releasing Neurotrophic Factors to Bridge Long Peripheral Nerve Defect

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2022.2909 ◽

2022 ◽

Vol 12 (2) ◽

pp. 329-334

Author(s):

Jie Dai ◽

Maimaitiaili Niyazi ◽

Jiang Xie

Keyword(s):

Peripheral Nerve ◽

Nerve Regeneration ◽

Neurotrophic Factors ◽

Peripheral Nerve Regeneration ◽

Physiological Saline ◽

Negative Control Group ◽

Negative Control ◽

Neural Regeneration ◽

Control Group ◽

Release System

Consistent application of neurotropic factors is necessary in peripheral nerve regeneration, yet challenging to achieve. Here we used a novel neurotropic factor controlled release system consisted of fibrin, fibronectin and hydrogel to slowly release two neurotrophic factors. At the same time, physiological saline and reverse nerve suturing were used as negative and positive control. A year after surgery, animals which were treated by neurotrophic factor slow release system achieved far better neural regeneration and myelination, as well as superior recovery of hindfoot than the negative control group. In the meanwhile, the results in the experimental group are still inferior to the nerve allograft group. In can be concluded from those results that, consistent releasing of neurotrophic factors can significantly promote long peripheral nerve regeneration, but still short of achieving the results same as the gold standard of autologous nerve grafting.

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Neurotrophic factors combined with stem cells in the treatment of sciatic nerve injury in rats:a meta-analysis

Bioscience Reports ◽

10.1042/bsr20211399 ◽

2021 ◽

Author(s):

Kuangpin Liu ◽

Wei Ma ◽

Chun-Yan Li ◽

Li-Yan Li

Keyword(s):

Stem Cells ◽

Sciatic Nerve ◽

Peripheral Nerve ◽

Nerve Regeneration ◽

Nerve Injury ◽

Neurotrophic Factors ◽

Neurotrophic Factor ◽

Meta Analysis ◽

Peripheral Nerve Regeneration ◽

Sciatic Nerve Injury

Treatment of peripheral nerve regeneration with stem cells alone has some limitations. For this reason, we evaluate the efficacy of neurotrophic factors combined with stem cell transplantation in the treatment of sciatic nerve injury in rats. PubMed, Cochrane Library, EMbase, WanFang, VIP and China National Knowledge Infrastructure databases were retrieved from inception to October 2021, and control experiments on neurotrophic factors combined with stem cells in the treatment of sciatic nerve injury in rats were searched. Nine articles and 551 rats were included in the meta-analysis. The results of meta-analysis confirmed that neurotrophic factor combined with stem cells for the treatment of sciatic nerve injury yielded more effective repair than normal rats with regard to sciatic nerve index, electrophysiological detection index, electron microscope observation index, and recovery rate of muscle wet weight. The conclusion is that neurotrophic factor combined with stem cells is more conducive to peripheral nerve regeneration and functional recovery than stem cells alone. However, due to the limitation of the quality of the included literature, the above conclusions need to be verified by randomized controlled experiments with higher quality and larger samples.

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