Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP)

2022 ◽  
Vol 119 ◽  
pp. 105536
Author(s):  
Min-Ran Wang ◽  
Lan-Fang Huang ◽  
Cong Guo ◽  
Jing Yang ◽  
Shuai Dong ◽  
...  
Keyword(s):  
Thiol Reactivity

scholarly journals Reaction of Chalcones with Cellular Thiols. The Effect of the 4-Substitution of Chalcones and Protonation State of the Thiols on the Addition Process. Diastereoselective Thiol Addition

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4332
Author(s):  
Fatemeh Kenari ◽  
Szilárd Molnár ◽  
Pál Perjési
Keyword(s):  
Biological Effects ◽  
Equilibrium Composition ◽  
Deprotonated Form ◽  
Degree Of Ionization ◽  
Thiol Reactivity ◽  
Michael Type Addition ◽  
Ph Conditions ◽  
The Difference ◽  
Initial Reactivity

Several biological effects of chalcones have been reported to be associated with their thiol reactivity. In vivo, the reactions can result in the formation of small-molecule or protein thiol adducts. Both types of reactions can play a role in the biological effects of this class of compounds. Progress of the reaction of 4-methyl- and 4-methoxychalcone with glutathione and N-acetylcysteine was studied by the HPLC-UV-VIS method. The reactions were conducted under three different pH conditions. HPLC-MS measurements confirmed the structure of the formed adducts. The chalcones reacted with both thiols under all incubation conditions. The initial rate and composition of the equilibrium mixtures depended on the ratio of the deprotonated form of the thiols. In the reaction of 4-methoxychalcone with N-acetylcysteine under strongly basic conditions, transformation of the kinetic adduct into the thermodynamically more stable one was observed. Addition of S-protonated N-acetylcysteine onto the polar double bonds of the chalcones showed different degrees of diastereoselectivity. Both chalcones showed a Michael-type addition reaction with the ionized and non-ionized forms of the investigated thiols. The initial reactivity of the chalcones and the equilibrium composition of the incubates showed a positive correlation with the degree of ionization of the thiols. Conversions showed systematic differences under each set of conditions. The observed differences can hint at the difference in reported biological actions of 4-methyl- and 4-methoxy-substituted chalcones.

scholarly journals Innenrücktitelbild: Cyclometalated Gold(III)‐Hydride Complexes Exhibit Visible Light‐Induced Thiol Reactivity and Act as Potent Photo‐Activated Anti‐Cancer Agents (Angew. Chem. 27/2020)

2020 ◽  
Vol 132 (27) ◽  
pp. 11252-11252
Author(s):  
Hejiang Luo ◽  
Bei Cao ◽  
Albert S. C. Chan ◽  
Raymond Wai‐Yin Sun ◽  
Taotao Zou
Keyword(s):  
Visible Light ◽  
Hydride Complexes ◽  
Thiol Reactivity ◽  
Anti Cancer

Nucleosomal structure as probed by H3 histone thiol reactivity

1987 ◽  
Vol 10 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Nicoletta Ferrari ◽  
Ulrich Pfeffer ◽  
Giorgio Vidali
Keyword(s):  
Thiol Reactivity ◽  
Nucleosomal Structure

Thiol Reactivity in Pressure-Unfolded β-Lactoglobulin. Antioxidative Properties and Thermal Refolding

1998 ◽  
Vol 46 (2) ◽  
pp. 425-430 ◽  
Author(s):  
Rikke Ege Møller ◽  
Henrik Stapelfeldt ◽  
Leif H. Skibsted
Keyword(s):  
Antioxidative Properties ◽  
Thiol Reactivity ◽  
Β Lactoglobulin

Cyclometalated Gold(III)‐Hydride Complexes Exhibit Visible Light‐Induced Thiol Reactivity and Act as Potent Photo‐Activated Anti‐Cancer Agents

2020 ◽  
Vol 132 (27) ◽  
pp. 11139-11145
Author(s):  
Hejiang Luo ◽  
Bei Cao ◽  
Albert S. C. Chan ◽  
Raymond Wai‐Yin Sun ◽  
Taotao Zou
Keyword(s):  
Visible Light ◽  
Hydride Complexes ◽  
Thiol Reactivity ◽  
Anti Cancer

Disulfide-Crosslinked Biomimetic Micelles: Formation, Thiol Reactivity and Cytotoxicity Behavior

2010 ◽  
Vol 211 (21) ◽  
pp. 2292-2300 ◽  
Author(s):  
Li-Ping Lv ◽  
Jian-Ping Xu ◽  
Xiang-Sheng Liu ◽  
Gong-Yan Liu ◽  
Xuan Yang ◽  
...  
Keyword(s):  
Thiol Reactivity
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