Single CpG island methylation is not sufficient to maintain the silenced expression of CASPASE-8 apoptosis-related gene among women with epithelial ovarian cancer

2014 ◽  
Vol 68 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Letícia da Conceição Braga ◽  
Luciana Maria Silva ◽  
Ana Paula Álvares da Silva Ramos ◽  
Josiane Barbosa Piedade ◽  
Paula Vieira Teixeira Vidigal ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cpg Island ◽  
Caspase 8 ◽  
Related Gene ◽  
Cpg Island Methylation ◽  
Apoptosis Related Gene

scholarly journals Apoptosis-related gene expression can predict the response of ovarian cancer cell lines to treatment with recombinant human TRAIL alone or combined with cisplatin

Clinics ◽  
2020 ◽  
Vol 75 ◽  
Author(s):  
Letícia da Conceição Braga ◽  
Nikole Gontijo Gonçales ◽  
Rafaela de Souza Furtado ◽  
Warne Pedro de Andrade ◽  
Luciana Maria Silva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Related Gene ◽  
Ovarian Cancer Cell Lines ◽  
Apoptosis Related Gene

Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma

2004 ◽  
Author(s):  
Pilar Gonzalez-Gomez ◽  
M. Bello ◽  
M. Inda ◽  
M. Alonso ◽  
Dolores Arjona ◽  
...  
Keyword(s):  
Cpg Island ◽  
Caspase 8 ◽  
Cpg Island Methylation

scholarly journals SRSF2 mutations in epithelial ovarian cancer

2017 ◽  
Vol 5 (3) ◽  
pp. 25-29 ◽  
Author(s):  
Milena Sabrina Nicoloso ◽  
Monica Schiappacassi ◽  
Alessandra Dall’Acqua ◽  
Sara D’Andrea ◽  
Sara Benevol ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Alternative Splicing ◽  
Epithelial Ovarian Cancer ◽  
Splicing Factor ◽  
Caspase 8 ◽  
Caspase 9 ◽  
Apoptotic Response ◽  
Apoptotic Protein ◽  
Platinum Chemotherapy ◽  
Protein Variants

Resistance to platinum chemotherapy regimens represents a major obstacle in the successful treatment of epithelial ovarian cancer (EOC) patients. Among the molecular mechanism responsible for resistance to platinum, alternative splicing, which is induced upon platinum treatment, can control apoptosis by regulating the expression of apoptotic protein variants with opposite functions. Alterations in alternative splicing are found in tumors and can hinder apoptotic response. In the present study we sequenced SRSF2, a splicing factor that regulates Caspase-8 and Caspase-9 variants, in search of mutations that could possibly explain alternative mechanisms of platinum resistant in EOC.

scholarly journals Promoter CpG Island Methylation of Genes in Key Cancer Pathways Associates with Clinical Outcome in High-Grade Serous Ovarian Cancer

2013 ◽  
Vol 19 (20) ◽  
pp. 5788-5797 ◽  
Author(s):  
Wei Dai ◽  
Constanze Zeller ◽  
Nahal Masrour ◽  
Nadeem Siddiqui ◽  
James Paul ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Outcome ◽  
Cpg Island ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Cancer Pathways ◽  
Cpg Island Methylation

scholarly journals CpG Island Methylation of DNA Damage Response Genes in Advanced Ovarian Cancer

2005 ◽  
Vol 65 (19) ◽  
pp. 8961-8967 ◽  
Author(s):  
Jens M. Teodoridis ◽  
Jacqueline Hall ◽  
Sharon Marsh ◽  
Hilary D. Kannall ◽  
Catriona Smyth ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cpg Island ◽  
Advanced Ovarian Cancer ◽  
Methylation Of Dna ◽  
Damage Response ◽  
Cpg Island Methylation

Impact of extended cycles of chemotherapy on survival outcome in recurrent epithelial ovarian cancer

2020 ◽  
Vol 159 ◽  
pp. 346-347
Author(s):  
W.Y. Hwang ◽  
S.I. Kim ◽  
M. Lee ◽  
K. Kim ◽  
J.H. No ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Survival Outcome
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