scholarly journals Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles: Synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo

2019 ◽  
Vol 116 ◽  
pp. 109006 ◽  
Author(s):  
Gang Zheng ◽  
Meizhu Zheng ◽  
Ben Yang ◽  
Hui Fu ◽  
Yongqing Li
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ph Sensitive ◽  
Breast Cancer Therapy ◽  
Solid Lipid ◽  
Nanoparticles Synthesis

scholarly journals Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Wenrui Wang ◽  
Mengyang Zhou ◽  
Yang Xu ◽  
Wei Peng ◽  
Shiwen Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Solid Lipid Nanoparticles ◽  
Drug Loading ◽  
Lipid Nanoparticles ◽  
Significant Inhibition ◽  
Migration And Invasion ◽  
Solid Lipid

Multidrug resistance (MDR) is a serious problem during cancer therapy. The purpose of the present study was to formulate D-α-Tocopheryl polyethylene glycol 1000 succinate-resveratrol-solid lipid nanoparticles (TPGS-Res-SLNs) to improve its therapeutic efficacy against breast cancer. In this study, the solvent injection method was used to prepare the TPGS-Res-SLNs. It was found that the TPGS-Res-SLNs exhibited zeta potential and drug-loading of −25.6 ± 1.3 mV and 32.4 ± 2.6%, respectively. Therefore, it was evident that the TPGS-Res-SLNs can increase cellular uptake of chemotherapeutic drugs, induce mitochondrial dysfunction, and augment tumor treatment efficiency by inducing apoptosis. Moreover, it was found that SKBR3/PR cells treated with TPGS-Res-SLNs exhibited significant inhibition of cell migration and invasion, as compared with free resveratrol. In addition, results from in vivo SKBR3/PR xenograft tumor models revealed that TPGS-Res-SLNs has better efficacy in promoting apoptosis of tumor cells owing to high therapeutic outcomes on tumors when compared with the efficacy of free resveratrol. In conclusion, the findings of the present study indicate significant potential for use of TPGS-Res-SLNs as an efficient drug delivery vehicle to overcome drug resistance in breast cancer therapy.

A pH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy

2015 ◽  
Vol 3 (22) ◽  
pp. 4514-4523 ◽  
Author(s):  
Zeng-Ying Qiao ◽  
Di Zhang ◽  
Chun-Yuan Hou ◽  
Si-Meng Zhao ◽  
Ya Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Ph Sensitive ◽  
Drug Formulation ◽  
Ph Responsive ◽  
Breast Cancer Therapy

The co-encapsulation of RA-V cyclopeptide and SQ molecules in pH-sensitive PAE micelles for efficient tumor therapy and imaging in vitro and in vivo.

Efficient in vitro and in vivo docetaxel delivery mediated by pH-sensitive LPHNPs for effective breast cancer therapy

2021 ◽  
Vol 203 ◽  
pp. 111760
Author(s):  
Rajesh Singh Jadon ◽  
Gajanand Sharma ◽  
Neeraj K. Garg ◽  
Nikunj Tandel ◽  
Kavita R. Gajbhiye ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Ph Sensitive ◽  
Breast Cancer Therapy

Solid Lipid Nanoparticles (SLNs) Gels for Topical Delivery of Aceclofenac in vitro and in vivo Evaluation

2013 ◽  
Vol 10 (6) ◽  
pp. 656-666 ◽  
Author(s):  
Sandipan Dasgupta ◽  
Surajit Ghosh ◽  
Subhabrata Ray ◽  
Bhaskar Mazumder
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Topical Delivery ◽  
Lipid Nanoparticles ◽  
In Vivo Evaluation ◽  
Solid Lipid

Transdermal Delivery of Curcumin-Loaded Solid Lipid Nanoparticles as Microneedle Patch: an In Vitro and In Vivo Study

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Ankitha Prabhu ◽  
Jobin Jose ◽  
Lalit Kumar ◽  
S Salwa ◽  
M Vijay Kumar ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Study ◽  
Solid Lipid ◽  
Microneedle Patch
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