scholarly journals Triptolide-nanoliposome-APRPG, a novel sustained-release drug delivery system targeting vascular endothelial cells, enhances the inhibitory effects of triptolide on laser-induced choroidal neovascularization

2020 ◽  
Vol 131 ◽  
pp. 110737
Author(s):  
Kunbei Lai ◽  
Yingqin Li ◽  
Yajun Gong ◽  
Longhui Li ◽  
Chuangxin Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Endothelial Cells ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Choroidal Neovascularization ◽  
Delivery System ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Inhibitory Effects ◽  
Release Drug

Implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system

2021 ◽  
Vol 11 ◽  
Author(s):  
Lalit Singh ◽  
Vijay Sharma
Keyword(s):  
Mathematical Model ◽  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Quality By Design ◽  
Design Principles ◽  
Release Drug

Aim: Aim of the present work is implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system Background: Quality by Design (QbD) approach refers to an advance approach to develop a optimized dosage form.QbD has become a vital modern scientific approach to develop a quality dosage form.In modern era of science researcher can develop a optimized dosage form with least effort, money and manpower. Objectives: Objective of research work wasthe successful development of optimized floating bioadhesive tablets of glipizide using floating-bioadhesive potential of cellulosic polymer and carbomersusing quality by design (QbD) approach. Method: Quality Target Product Profile (QTPP) of drug delivery system was defined as well as critical quality attributes (CQAs) were identified. A face centered central composite design (CCD) was utilized in assessing the impact of individual critical material attribute (CMA) like Hydro Propyl Methyl Cellulose K4M(HPMC K4M)and Carbopol 934P (CP 934P) and their interactions, using least experimentation. Formulations were developed and quantitative impact on CQAs was determined using mathematical model. The optimized formulation was obtained and characterized for in-vitro as well as in-vivo parameters. Results: A Fishikawa diagram and Failure Mode and Effect Analysis (FMEA) were performed to identify potential failure modes associated with the dosage form. The optimum formulation was embarked upon using mathematical model developed yielding desired CQAs followed for confirmation of data. Sustained release drug delivery system was successfully developed by using QbD approach. In-vivo X-ray imaging in rabbit and γ-scintigraphic study in manconfirmed the buoyant nature of the mucoadhesive floating tablet for 8 h in the upper gastrointestinal tract. Conclusion: Optimized formulation shows phenomenal floating, bioadhesive properties and drug release retardation characteristics, utilizing a mixture of cost-effective polymers Hence, QbD approach may be regarded as an important tool in development of floating bioadhesive CR dosage forms.

Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy

2019 ◽  
Vol 7 (37) ◽  
pp. 5677-5687 ◽  
Author(s):  
Li Zhang ◽  
Dongjian Shi ◽  
Chunling Shi ◽  
Tatsuo Kaneko ◽  
Mingqing Chen
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
High Drug ◽  
Release Drug ◽  
Drug Loading Efficiency ◽  
High Drug Loading

A novel multi-arm polyphosphoester-based nanomaterial provides high drug loading efficiency and sustained-release drug delivery for effective chemotherapy.

Gastro-retentive drug delivery system for treatment of Ulcer

2019 ◽  
Vol 3 (02) ◽  
pp. 203-210
Author(s):  
Mohd Vaseem Fateh ◽  
Vikas Kumar ◽  
Renu Chaudhary ◽  
Vivak Ujjwal
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Concentration ◽  
Oral Dosage ◽  
Oral Drug ◽  
Time Duration ◽  
Release Drug

Due to the comfort of administration, economical and extensibility in formulation, the most adopted route to the systemic circulation is the oral route regardless of the astounding elevation in the drug delivery. Oral drug delivery is the most comforting method of delivery due to its comforting method of delivery, due to its better solubility, accurate dosage and simpler production. Approximately 90% of the drugs are administered orally of which solid oral dosage form is the most chosen class of medicaments. Conventional dosage forms usually exhibit the serum drug concentration fluctuations and irregularities in drug concentration in the tissues with resultant toxicity, low bioavailability and thus low therapeutic effects. Accordingly, the concept of the oral sustained release drug delivery system has gained popularity in advancement. Sustained release drug deliveries have steady and consistent drug release over longer time duration. Here, if the drug release is consistent over the time duration, it is supposed to be controlled release system, however if the system doesn’t achieve the constant drug release but shows the drug release over the longer duration compared to the conventional system, it is prolonged release systems. These systems are hot in the recent trend as they offer huge designing and adaptability range during formulation

pH-responsive and sustained release drug delivery system of BSA coated CDs-DOX

2021 ◽  
pp. 131358
Author(s):  
Qianqian Duan ◽  
Jiaying Shi ◽  
Lan Zhou ◽  
Boye Zhang ◽  
Xiaoyuan Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Release Drug

Preparation and Evaluation of Chitosin-Coated Alginate/Gelatin Microspheres for Sustained-Release Drug Delivery System In Vitro

2013 ◽  
Vol 651 ◽  
pp. 227-231
Author(s):  
Qiang Song Wang ◽  
Yuan Lu Cui ◽  
Tian Jiao Dong
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Soluble ◽  
Average Particle ◽  
Gelatin Microspheres ◽  
Release Drug ◽  
Ft Ir

The purpose of the study was to prepare and evaluation chitosin-coated alginate/gelatin microspheres for sustained-release drug delivery system in vitro. The microspheres were prepared with an emulsification technique, characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimetry (DSC). The average particle size of the chitosan-coated alginate/gelatin microspheres was uniform. The results of FT-IR and DSC showed that the microspheres were formed by intermolecular cross-linkages between chitosan and gelatin. The results also implied that the microsphere were a practicable dosage form to increase drug loading ratio for the poorly water-soluble drugs by encapsulated with chitosan. In vitro release of the microsphere indicated that it had a satisfactory sustained-release behavior for the sustained-release drug delivery system.

Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

2016 ◽  
Vol 43 (3) ◽  
pp. 409-420 ◽  
Author(s):  
Muhammad Tahir Haseeb ◽  
Muhammad Ajaz Hussain ◽  
Sajid Bashir ◽  
Muhammad Umer Ashraf ◽  
Naveed Ahmad
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Release Drug

Design and preparation acid-activated montmorillonite sustained-release drug delivery system for dexibuprofen in vitro and in vivo evaluations

2018 ◽  
Vol 163 ◽  
pp. 178-185 ◽  
Author(s):  
Tingting Li ◽  
Lele Zhao ◽  
Ziliang Zheng ◽  
Min Zhang ◽  
Yidan Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Drug
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