scholarly journals Entresto protected the cardiomyocytes and preserved heart function in cardiorenal syndrome rat fed with high-protein diet through regulating the oxidative stress and Mfn2-mediated mitochondrial functional integrity

2021 ◽  
Vol 144 ◽  
pp. 112244
Author(s):  
Jui-Ning Yeh ◽  
Ya Yue ◽  
Yi-Ching Chu ◽  
Chi-Ruei Huang ◽  
Chih-Chao Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Function ◽  
High Protein Diet ◽  
Cardiorenal Syndrome ◽  
High Protein ◽  
Protein Diet ◽  
Functional Integrity

High-Protein Diet Ameliorates Arsenic-Induced Oxidative Stress and Antagonizes Uterine Apoptosis in Rats

2019 ◽  
Vol 192 (2) ◽  
pp. 222-233 ◽  
Author(s):  
Prerona Biswas ◽  
Aparna Mukhopadhyay ◽  
Syed Nazrul Kabir ◽  
Prabir Kumar Mukhopadhyay
Keyword(s):  
Oxidative Stress ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

scholarly journals High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus

2019 ◽  
Vol 20 (7) ◽  
pp. 1547 ◽  
Author(s):  
Ewa Żebrowska ◽  
Mateusz Maciejczyk ◽  
Małgorzata Żendzian-Piotrowska ◽  
Anna Zalewska ◽  
Adrian Chabowski
Keyword(s):  
Oxidative Stress ◽  
Cerebral Cortex ◽  
Oxidative Damage ◽  
Antioxidant Defense ◽  
High Protein Diet ◽  
Brain Structures ◽  
High Protein ◽  
Protein Diet ◽  
Standard Diet ◽  
The Impact

This is the first study to analyze the impact of high protein diet (HPD) on antioxidant defense, redox status, as well as oxidative damage on both a local and systemic level. Male Wistar rats were divided into two equal groups (n = 9): HPD (44% protein) and standard diet (CON; 24.2% protein). After eight weeks, glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), superoxide dismutase-1 (SOD-1), reduced glutathione (GSH), uric acid (UA), total antioxidant (TAC)/oxidant status (TOS) as well as advanced glycation end products (AGE), 4-hydroxynonenal (4-HNE), and malondialdehyde (MDA) were analyzed in the serum/plasma, cerebral cortex, and hypothalamus of HPD and CON rats. HPD resulted in higher UA concentration and activity of GPx and CAT in the hypothalamus, whereas in the cerebral cortex these parameters remained unchanged. A significantly lower GSH content was demonstrated in the plasma and hypothalamus of HPD rats when compared to CON rats. Both brain structures expressed higher content of 4-HNE and MDA, whereas AGE was increased only in the hypothalamus of HPD animals. Despite the enhancement in antioxidant defense in the hypothalamus, this mechanism does not protect the hypothalamus from oxidative damage in rats. Hypothalamus is more susceptible to oxidative stress caused by HPD.

scholarly journals Protective effect of Emilia sonchifolia (L.) against high protein diet induced oxidative stress in pancreas of Wistar rats

2012 ◽  
Vol 4 (1) ◽  
pp. 60 ◽  
Author(s):  
VelliyurKanniappan Gopalakrishnan ◽  
Dominic Sophia ◽  
Paramasivam Ragavendran ◽  
ChinthamonyArul Raj
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Wistar Rats ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

scholarly journals The therapeutic impact of entresto on protecting against cardiorenal syndrome-associated renal damage in rats on high protein diet

2019 ◽  
Vol 116 ◽  
pp. 108954 ◽  
Author(s):  
Chih-Chao Yang ◽  
Yen-Ta Chen ◽  
Chih-Hung Chen ◽  
Yi-Chen Li ◽  
Pei-Lin Shao ◽  
...  
Keyword(s):  
Renal Damage ◽  
High Protein Diet ◽  
Cardiorenal Syndrome ◽  
High Protein ◽  
Protein Diet ◽  
Therapeutic Impact

Chronic high-protein diet induces oxidative stress and alters the salivary gland function in rats

2017 ◽  
Vol 84 ◽  
pp. 6-12 ◽  
Author(s):  
Urszula Kołodziej ◽  
Mateusz Maciejczyk ◽  
Wiesława Niklińska ◽  
Danuta Waszkiel ◽  
Małgorzata Żendzian-Piotrowska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Salivary Gland ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Salivary Gland Function ◽  
Gland Function

scholarly journals A high-protein diet increases faecal IgA concentrations in baby pigs

2008 ◽  
Vol 67 (OCE5) ◽  
Author(s):  
F. Vitari ◽  
A. Morise ◽  
M. Formal ◽  
C. Garcia ◽  
K. Mace ◽  
...  
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

scholarly journals Measurement of the Intestinal pH in Mice under Various Conditions Reveals Alkalization Induced by Antibiotics

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 180
Author(s):  
Kouki Shimizu ◽  
Issei Seiki ◽  
Yoshiyuki Goto ◽  
Takeshi Murata
Keyword(s):  
Antibiotic Treatment ◽  
High Protein Diet ◽  
Intestinal Bacteria ◽  
High Protein ◽  
Protein Diet ◽  
Germ Free ◽  
Treatment Regimens ◽  
Ph Values ◽  
Specific Pathogen ◽  
The Stability

The intestinal pH can greatly influence the stability and absorption of oral drugs. Therefore, knowledge of intestinal pH is necessary to understand the conditions for drug delivery. This has previously been measured in humans and rats. However, information on intestinal pH in mice is insufficient despite these animals being used often in preclinical testing. In this study, 72 female ICR mice housed in SPF (specific pathogen-free) conditions were separated into nine groups to determine the intestinal pH under conditions that might cause pH fluctuations, including high-protein diet, ageing, proton pump inhibitor (PPI) treatment, several antibiotic treatment regimens and germ-free mice. pH was measured in samples collected from the ileum, cecum and colon, and compared to control animals. An electrode, 3 mm in diameter, enabled accurate pH measurements with a small amount of gastrointestinal content. Consequently, the pH values in the cecum and colon were increased by high-protein diet, and the pH in the ileum was decreased by PPI. Drastic alkalization was induced by antibiotics, especially in the cecum and colon. The alkalized pH values in germ-free mice suggested that the reduction in the intestinal bacteria caused by antibiotics led to alkalization. Alkalization of the intestinal pH caused by antibiotic treatment was verified in mice. We need further investigations in clinical settings to check whether the same phenomena occur in patients.

scholarly journals The Colonic Microbiome and Epithelial Transcriptome Are Altered in Rats Fed a High-Protein Diet Compared with a Normal-Protein Diet

2016 ◽  
Vol 146 (3) ◽  
pp. 474-483 ◽  
Author(s):  
Chunlong Mu ◽  
Yuxiang Yang ◽  
Zhen Luo ◽  
Leluo Guan ◽  
Weiyun Zhu
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Normal Protein Diet
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