Metabolic engineering of Klebsiella pneumoniae J2B for co-production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol: Reduction of acetate and other by-products

2017 ◽  
Vol 244 ◽  
pp. 1096-1103 ◽  
Author(s):  
Yeounjoo Ko ◽  
Eunhee Seol ◽  
Balaji Sundara Sekar ◽  
Seongjin Kwon ◽  
Jaehyeon Lee ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Klebsiella Pneumoniae ◽  
Hydroxypropionic Acid ◽  
By Products

scholarly journals Redistribution of Carbon Flux toward 2,3-Butanediol Production in Klebsiella pneumoniae by Metabolic Engineering

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e105322 ◽  
Author(s):  
Borim Kim ◽  
Soojin Lee ◽  
Daun Jeong ◽  
Jeongmo Yang ◽  
Min-Kyu Oh ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Klebsiella Pneumoniae ◽  
Carbon Flux

scholarly journals Bio-based 3-hydroxypropionic Acid: A Review

2017 ◽  
Vol 62 (2) ◽  
pp. 156 ◽  
Author(s):  
Aladár Vidra ◽  
Áron Németh
Keyword(s):  
Metabolic Engineering ◽  
Acrylic Acid ◽  
Methyl Acrylate ◽  
Metabolic Pathways ◽  
Commercial Production ◽  
Genetically Engineered ◽  
High Yield ◽  
Biochemical Pathways ◽  
Genetically Engineered Microorganism ◽  
Hydroxypropionic Acid

3-hydroxypropionic acid is a commercially valuable, important platform chemical. It can serve as a precursor for several key compound, such as acrylic acid, 1,3-propanediol, methyl acrylate, acrylamide, ethyl 3-HP, malonic acid, propiolactone and acrylonitrile. Several microorganisms can produce through a range of metabolic pathways. It is indispensable for the commercial production of 3-HP to use cheap and abundant substrates and also to produce in highly efficient processes which could result high yield, titer and productivity. Because  of the fact, that natural microorganism do not perform these conditions, metabolic engineering and genetically engineered microorganism are widely used for research and production as well. Several metabolic pathways are introduced to utilize glucose or glycerol for 3-HP production. In this overview naturally producer microorganisms, synthetic biochemical pathways, results from the recent years and recovery of 3-HP are detailed.

Production of 3-hydroxypropionic acid by recombinant Klebsiella pneumoniae based on aeration and ORP controlled strategy

2009 ◽  
Vol 26 (6) ◽  
pp. 1679-1685 ◽  
Author(s):  
Jian-Guo Zhu ◽  
Xiao-Jun Ji ◽  
He Huang ◽  
Jun Du ◽  
Shuang Li ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Hydroxypropionic Acid

Recent advances in the metabolic engineering of microorganisms for the production of 3-hydroxypropionic acid as C3 platform chemical

2013 ◽  
Vol 97 (8) ◽  
pp. 3309-3321 ◽  
Author(s):  
Kris Niño G. Valdehuesa ◽  
Huaiwei Liu ◽  
Grace M. Nisola ◽  
Wook-Jin Chung ◽  
Seung Hwan Lee ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Platform Chemical ◽  
Recent Advances ◽  
Hydroxypropionic Acid
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