Epigenetic regulations enhance adaptability and valorization efficiency in Eisenia fetida and Eudrilus eugeniae during vermicomposting of textile sludge: Insights on repair mechanisms of metal-induced genetic damage and oxidative stress

2022 ◽  
Vol 345 ◽  
pp. 126493
Author(s):  
Sarmistha Paul ◽  
Linee Goswami ◽  
Ratul Pegu ◽  
Subhendu Kumar Chatterjee ◽  
Satya Sundar Bhattacharya
Keyword(s):  
Oxidative Stress ◽  
Eisenia Fetida ◽  
Eudrilus Eugeniae ◽  
Genetic Damage ◽  
Repair Mechanisms ◽  
Epigenetic Regulations ◽  
Textile Sludge ◽  
And Oxidative Stress

scholarly journals Cellular repair mechanisms triggered by exposure to silver nanoparticles and ionic silver in embryonic zebrafish cells

2021 ◽  
Author(s):  
Ana C. Quevedo ◽  
Iseult Lynch ◽  
Eugenia Valsami-Jones
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Cell Death ◽  
Zebrafish Embryo ◽  
Genetic Damage ◽  
Cellular Repair ◽  
Embryo Cells ◽  
Repair Mechanisms ◽  
Toxicity Pathways ◽  
Dynamic Interplay

The dynamic interplay between toxicity pathways (oxidative stress, calcium disturbances, genetic damage) caused by nanoparticles and the repair mechanisms of inhibition of cell division and induction of cell death is explored in zebrafish embryo cells.

Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice

2021 ◽  
Author(s):  
Paulina Nguyen-Powanda ◽  
Bernard Robaire
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Repair ◽  
Superoxide Dismutase ◽  
Germ Cells ◽  
Superoxide Dismutase 1 ◽  
Male Germ Cells ◽  
Dna Repair Mechanisms ◽  
Repair Mechanisms ◽  
And Oxidative Stress

Abstract The efficiency of antioxidant defense system decreases with aging, thus resulting in high levels of reactive oxygen species (ROS) and DNA damage in spermatozoa. This damage can lead to genetic disorders in the offspring. There are limited studies investigating the effects of the total loss of antioxidants, such as superoxide dismutase-1 (SOD1), in male germ cells as they progress through spermatogenesis. In this study, we evaluated the effects of aging and removing SOD1 (in male germ cells of SOD1-null (Sod1−/−) mice) in order to determine the potential mechanism(s) of DNA damage in these cells. Immunohistochemical analysis showed an increase in lipid peroxidation and DNA damage in the germ cells of aged wild-type (WT) and Sod1−/− mice of all age. Immunostaining of OGG1, a marker of base excision repair (BER), increased in aged WT and young Sod1−/− mice. In contrast, immunostaining intensity of LIGIV and RAD51, markers of non-homologous end-joining (NHEJ) and homologous recombination (HR), respectively, decreased in aged and Sod1−/− mice. Gene expression analysis showed similar results with altered mRNA expression of these key DNA repair transcripts in pachytene spermatocytes and round spermatids of aged and Sod1−/− mice. Our study indicates that DNA repair pathway markers of BER, NHEJ, and HR are differentially regulated as a function of aging and oxidative stress in spermatocytes and spermatids, and aging enhances the repair response to increased oxidative DNA damage, whereas impairments in other DNA repair mechanisms may contribute to the increase in DNA damage caused by aging and the loss of SOD1.

Hydroxyl radical generation and oxidative stress in earthworms (Eisenia fetida) exposed to decabromodiphenyl ether (BDE-209)

Ecotoxicology ◽  
2011 ◽  
Vol 20 (5) ◽  
pp. 993-999 ◽  
Author(s):  
Xianchuan Xie ◽  
Yingxin Wu ◽  
Mengying Zhu ◽  
You-kuan Zhang ◽  
Xiaorong Wang
Keyword(s):  
Oxidative Stress ◽  
Hydroxyl Radical ◽  
Eisenia Fetida ◽  
Decabromodiphenyl Ether ◽  
Radical Generation ◽  
And Oxidative Stress ◽  
Bde 209

The hydroxyl radical generation and oxidative stress for the earthworm Eisenia fetida exposed to tetrabromobisphenol A

Ecotoxicology ◽  
2009 ◽  
Vol 18 (6) ◽  
pp. 693-699 ◽  
Author(s):  
Yingang Xue ◽  
Xueyuan Gu ◽  
Xiaorong Wang ◽  
Cheng Sun ◽  
Xianghua Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydroxyl Radical ◽  
Eisenia Fetida ◽  
Tetrabromobisphenol A ◽  
Radical Generation ◽  
And Oxidative Stress

DNA damage and oxidative stress induced by imidacloprid exposure in the earthworm Eisenia fetida

Chemosphere ◽  
2016 ◽  
Vol 144 ◽  
pp. 510-517 ◽  
Author(s):  
Juan Wang ◽  
Jinhua Wang ◽  
Guangchi Wang ◽  
Lusheng Zhu ◽  
Jun Wang
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Eisenia Fetida ◽  
And Oxidative Stress

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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