Coenzyme A-aptamer-facilitated label-free electrochemical stripping strategy for sensitive detection of histone acetyltransferase activity

2020 ◽  
Vol 150 ◽  
pp. 111934 ◽  
Author(s):  
Dandan Hu ◽  
Yufang Hu ◽  
Tianyu Zhan ◽  
Yudi Zheng ◽  
Pingjian Ran ◽  
...  
Keyword(s):  
Histone Acetyltransferase ◽  
Coenzyme A ◽  
Sensitive Detection ◽  
Label Free ◽  
Acetyltransferase Activity ◽  
Electrochemical Stripping ◽  
Histone Acetyltransferase Activity

Unique electrocatalytic activity of a nucleic acid-mimicking coordination polymer for the sensitive detection of coenzyme A and histone acetyltransferase activity

2015 ◽  
Vol 51 (99) ◽  
pp. 17611-17614 ◽  
Author(s):  
Yufang Hu ◽  
Siyu Chen ◽  
Yitao Han ◽  
Hongjun Chen ◽  
Qin Wang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Coordination Polymer ◽  
Electrocatalytic Activity ◽  
Histone Acetyltransferase ◽  
Coenzyme A ◽  
Sensitive Detection ◽  
Acetyltransferase Activity ◽  
Histone Acetyltransferase Activity

Unique electrocatalytic activity of a nucleic acid-mimicking CoA–Ag(i) CP was discovered and used for the sensitive detection of CoA and HAT activity.

Aptamer-mediated rolling circle amplification for label-free and sensitive detection of histone acetyltransferase activity

2021 ◽  
Vol 57 (16) ◽  
pp. 2041-2044
Author(s):  
Su Jiang ◽  
Meng Liu ◽  
Wei Tantai ◽  
Qinfeng Xu ◽  
Xiaoran Zou ◽  
...  
Keyword(s):  
Histone Modification ◽  
Histone Acetyltransferase ◽  
Rolling Circle Amplification ◽  
Sensitive Detection ◽  
Label Free ◽  
Site Specific ◽  
Rolling Circle ◽  
Acetyltransferase Activity ◽  
Label Free Detection ◽  
Histone Acetyltransferase Activity

An aptamer-mediated histone modification site-specific rolling circle amplification is developed for label-free detection of histone-modifying enzyme at the femtomolar level.

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