Graphdiyne nanosheet as a novel sensing platform for self-enhanced electrochemiluminescence of MOF enriched ruthenium (II) in the presence of dual co-reactants for detection of tumor marker

ZusammenfassungAuf der Basis ermutigender Veröffentlichungen über die Immunszintigraphie bei kolorektalen Karzinomen sowie eigener immunhistochemischer und immunszintigraphischer Befunde an Pankreaskarzinom-Transplantaten auf der Nacktmaus untersuchten wir die diagnostischen Möglichkeiten mit 131J-markierten Antikörpern gegen die Tumor-Marker CA 19-9 und CEA bei 21 Patienten mit Pankreaskarzinom. Zum Vergleich dienten die Untersuchungsergebnisse von weiteren 10 Patienten mit kolorektalem Karzinom, 2 Patienten mit Gallengangs- und 1 mit Magen-Karzinom. Planare Szintigramme der Verdachtsregionen in 2-4 Sichten wurden mehrfach bis 6 Tage nach i.v. Infusion von 2 mCi eines Cocktails aus 131J-anti-CA 19-9 und -anti-CEA aufgenommen. SPECT wurde außerdem 3-4 Tage p.i., zuletzt auch früher, durchgeführt. Primäre Tumoren und Metastasen im Oberbauch waren wegen geringerer Tumor/Umgebungs-Relation der Traceraktivität schwieriger nachzuweisen und zu lokalisieren als kolorektale Karzinome im Unterbauch. Die Tumorabgrenzung wurde in planaren Szintigrammen meist erst 5-6 Tage p.i. oder später erkennbar. SPECT wies dieselben Befunde bereits 3 Tage p. i. oder früher nach. Die Lokalisation und die topographische Zuordnung gelang mit SPECT leichter und häufiger, somit der Nachweis sicherer und empfindlicher. Größere Tumoren stellten sich auch in Fällen ohne erhöhte Serumkonzentration der Tumormarker dar. Der Immunszintigraphie des Pankreaskarzinoms und anderer Karzinommanifestationen im Oberbauch kommt gegenwärtig eine eingeschränkte diagnostische Bedeutung zu; methodische Verbesserungen erscheinen notwendig und möglich.

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Senile erythroderma with low serum IgE and high titers of tumor marker, squamous cell carcinoma(SCC)-related antigens. Successful glyteer ointment therapy: Reports of 2 cases.

Nishi Nihon Hifuka ◽

10.2336/nishinihonhifu.51.805 ◽

1989 ◽

Vol 51 (4) ◽

pp. 805-809 ◽

Cited By ~ 2

Author(s):

Kazunobu OTOYAMA ◽

Yasuhiro HORIUCHI ◽

Yasuhide SAITO ◽

Tomoo YOKOTA ◽

Mikio MASUZAWA

Keyword(s):

Squamous Cell Carcinoma ◽

Tumor Marker ◽

Cell Carcinoma ◽

Squamous Cell ◽

Serum Ige ◽

Low Serum

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Analysis of PD-L1 expression in salivary duct carcinoma with its efficacy as a tumor marker

Korean Society for Head and Neck Oncology ◽

10.21593/kjhno/2019.35.1.13 ◽

2019 ◽

Vol 35 (1) ◽

pp. 13-20

Author(s):

Yong Ju Lee ◽

Yoon Woo Koh ◽

Sun Och Yoon ◽

Hyang Joo Ryu ◽

Hye Ryun Kim ◽

...

Keyword(s):

Tumor Marker ◽

Salivary Duct Carcinoma ◽

Salivary Duct ◽

Duct Carcinoma

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Optical Sensors for Detection of Amino Acids

Current Medicinal Chemistry ◽

10.2174/0929867324666171106161410 ◽

2018 ◽

Vol 25 (19) ◽

pp. 2272-2290 ◽

Cited By ~ 2

Author(s):

Aafrin M. Pettiwala ◽

Prabhat K. Singh

Keyword(s):

Amino Acids ◽

Optical Sensors ◽

Supramolecular Assemblies ◽

Significant Activity ◽

Physiological Level ◽

Biological Scaffolds ◽

Detection Systems ◽

Sensing Platform ◽

Neurological Conditions ◽

Detailed Search

Background: Amino acids are crucially involved in a myriad of biological processes. Any aberrant changes in physiological level of amino acids often manifest in common metabolic disorders, serious neurological conditions and cardiovascular diseases. Thus, devising methods for detection of trace amounts of amino acids becomes highly elemental to their efficient clinical diagnosis. Recently, the domain of developing optical sensors for detection of amino acids has witnessed significant activity which is the focus of the current review article. Methods: We undertook a detailed search of the peer-reviewed literature that primarily deals with optical sensors for amino acids and focuses on the use of different type of materials as a sensing platform. Results: Ninety-five papers have been included in the review, majority of which deal with optical sensors. We attempt to systematically classify these contributions based on the applications of various chemical and biological scaffolds such as polymers, supramolecular assemblies, nanoparticles, DNA, heparin etc for the sensing of amino acids. This review identifies that supramolecular assemblies and nanomaterial continue to be commonly used platforms to devise sensors for amino acids followed by surfactant assemblies. Conclusion: The broad implications of amino acids in human health and diagnosis have stirred a lot of interest to develop optimized optical detection systems for amino acids in recent years, using different materials based on chemical and biological scaffolds. We have also attempted to highlight the merits and demerits of some of the noteworthy sensor systems to instigate further efforts for constructing amino acids sensor based on unconventional concepts.

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Selective Sensing Platform Utilizing Graphitized Multi-Walled Carbon Nanotubes for Monitoring of Ondansetron and Paracetamol

Current Nanoscience ◽

10.2174/1573413716666201207142211 ◽

2020 ◽

Vol 16 ◽

Author(s):

Biljana Nigović ◽

Iva Šimunić ◽

Ana Mornar

Keyword(s):

Carbon Nanotubes ◽

Cation Exchange ◽

Supporting Electrolyte ◽

Polymer Concentration ◽

Fixed Dose ◽

Sensing Platform ◽

Multi Walled Carbon Nanotubes ◽

Electroanalytical Method ◽

Walled Carbon Nanotubes

Background: Ondansetron and paracetamol are often co-administrated to prevent and treat nausea and vomiting caused by anaesthesia and to control of postoperative pain. In addition, ondansetron is used as the first-line antiemetic in paracetamol overdose. Therefore, selective and sensitive method for their simultaneous analysis is of a great importance. The electroanalytical methods are highly sensitive and offer many possibilities for new sensor platform design. However, at present, no electroanalytical method for simultaneous determination of these drugs has been proposed. Objective: The aim of this study was to develop a novel nanosensor for selective monitoring of ondansetron and paracetamol in pharmaceutical and biological samples without expensive and time-consuming pretreatments. Methods: The graphitized multi-walled carbon nanotubes embedded in a cation exchange polymer matrix was selected, among various surface functionalizations evaluated, to design novel sensor. Based on its excellent sensing performance, the first electroanalytical method was developed for rapid concurrent determination of investigated drugs. Results: The scanning electron microscopy study showed interlinked nanoporous network structure and highly enlarged active surface. The developed sensor facilitated electron transfer in the oxidation of both drugs and tremendously enhanced the adsorption capacity for ondasetron, thus exhibiting significant increase of drug responses and sensitivity. To obtain much sensitive response of investigated drugs the effect of pH values of supporting electrolyte, dispersed nanomaterial amount, the cation exchange polymer concentration, drop-casting volume of nanocomposite suspension, accumulation potential and deposition time on the peak current was evaluated. The developed electroanalytical method was validated and practical utility of the proposed nanosensor was tested. Conclusion: The developed sensor is promising sensing platform with a fast response time for analysis of ondansetron and paracetamol at very different concentration levels found in their fixed-dose combination and human serum sample after recommended daily doses showing its potential usage in pharmaceutical quality control and clinical research.

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