scholarly journals Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

2019 ◽  
Vol 29 (6) ◽  
pp. 739-743 ◽  
Author(s):  
SeonJu Park ◽  
Youn Hee Nam ◽  
Isabel Rodriguez ◽  
Jun Hyung Park ◽  
Hee Jae Kwak ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Chemical Constituents ◽  
Persea Americana ◽  
Protective Effects ◽  
Hair Cell Damage

Protective effects of edaravone against cisplatin-induced hair cell damage in zebrafish

2013 ◽  
Vol 77 (6) ◽  
pp. 1025-1031 ◽  
Author(s):  
Seok Jin Hong ◽  
Gi Jung Im ◽  
Jiwon Chang ◽  
Sung Won Chae ◽  
Seung Hoon Lee ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Protective Effects ◽  
Hair Cell Damage

Protective role of quercetin against cisplatin-induced hair cell damage in zebrafish embryos

2015 ◽  
Vol 34 (11) ◽  
pp. 1043-1052 ◽  
Author(s):  
SK Lee ◽  
KH Oh ◽  
AY Chung ◽  
HC Park ◽  
SH Lee ◽  
...  
Keyword(s):  
Hair Cell ◽  
Hair Cells ◽  
Cell Damage ◽  
Protective Role ◽  
Ultrastructural Changes ◽  
Control Group ◽  
Zebrafish Embryos ◽  
Protective Effects ◽  
Hair Cell Damage

Background and objectives: The aim of this study was to evaluate the protective effects of quercetin on cisplatin-induced hair cell damage in transgenic zebrafish embryos. Materials and methods: Five days postfertilization zebrafish embryos were exposed to 1 mM cisplatin and quercetin at 10, 50, 100, or 200 μM for 4 h. Hair cells within neuromasts of the supraorbital, otic, and occipital lateral lines were analyzed by fluorescent microscopy ( n = 10). Survival of hair cells was calculated as the average number of hair cells in the control group that were not exposed to cisplatin. Ultrastructural changes were evaluated using scanning electron microscopy. Results: Hair cell damage in neuromasts was decreased by co-treatment of quercetin and cisplatin (quercetin 100 μM: 8.6 ± 1.1 cells; 1 mM cisplatin only: 5.0 ± 0.5 cells; n = 10, p < 0.05); apoptosis of hair cells examined by special stain was also decreased by quercetin. The ultrastructure of hair cells within neuromasts was preserved in zebrafish by the combination of quercetin (100 μM) and cisplatin (1 mM). Conclusion: In conclusion, quercetin showed protective effects against cisplatin-induced toxicity in a zebrafish model. The results of this study suggest the possibility of a protective role of quercetin against cisplatin-induced apoptotic cell death in zebrafish.

Hair Cell Damage in the Inner Ear of the Guinea Pig Due to Noise in a Workshop

1987 ◽  
Vol 103 (5) ◽  
pp. 204-211 ◽  
Author(s):  
B. Erlandsson ◽  
H. Hakanson ◽  
A. Ivarsson ◽  
P. Nilsson ◽  
J. Wersall
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Damage ◽  
Hair Cell Damage

XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway

2021 ◽  
pp. 114513
Author(s):  
Dekun Gao ◽  
Hui Wu ◽  
Huiqun Jie ◽  
Min Liang ◽  
Dongzhen Yu ◽  
...  
Keyword(s):  
Hair Cell ◽  
Caspase 3 ◽  
Cell Damage ◽  
Hair Cell Damage

Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss

2015 ◽  
Vol 166 (5) ◽  
pp. 440-450 ◽  
Author(s):  
Maki Niihori ◽  
Terry Platto ◽  
Suzu Igarashi ◽  
Audriana Hurbon ◽  
Allison M. Dunn ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Drug Development ◽  
Hair Cell ◽  
High Throughput ◽  
Cell Damage ◽  
Swimming Behavior ◽  
Development Platform ◽  
Hair Cell Damage
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