The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells

2019 ◽  
Vol 27 (8) ◽  
pp. 1577-1587 ◽  
Author(s):  
Yi Zhang ◽  
Ying-Hua Luo ◽  
Xian-Ji Piao ◽  
Gui-Nan Shen ◽  
Jia-Ru Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Apoptosis Induction ◽  
Human Lung Cancer Cells

Peroxide Is a Key Mediator of Bcl-2 Down-Regulation and Apoptosis Induction by Cisplatin in Human Lung Cancer Cells

2007 ◽  
Vol 73 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Liying Wang ◽  
Pithi Chanvorachote ◽  
David Toledo ◽  
Christian Stehlik ◽  
Robert R. Mercer ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Apoptosis Induction ◽  
Down Regulation ◽  
Human Lung Cancer Cells

Combined Effects of Sulindac and Suberoylanilide Hydroxamic Acid on Apoptosis Induction in Human Lung Cancer Cells

2007 ◽  
Vol 73 (3) ◽  
pp. 1005-1012 ◽  
Author(s):  
Sung-Keum Seo ◽  
Hyeon-Ok Jin ◽  
Hyung-Chahn Lee ◽  
Sang-Hyeok Woo ◽  
Eun-Sung Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Hydroxamic Acid ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Suberoylanilide Hydroxamic Acid ◽  
Combined Effects ◽  
Apoptosis Induction ◽  
Human Lung Cancer Cells

Proteomic analysis of apoptosis induction in human lung cancer cells by recombinant MVL

Amino Acids ◽  
2010 ◽  
Vol 41 (4) ◽  
pp. 923-932 ◽  
Author(s):  
Yuqin Li ◽  
Bochao Zhang ◽  
Xiaoqin Wang ◽  
Huidan Yan ◽  
Gu Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Proteomic Analysis ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Apoptosis Induction ◽  
Human Lung Cancer Cells

scholarly journals Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e13026 ◽  
Author(s):  
Jieru Meng ◽  
Bingliang Fang ◽  
Yong Liao ◽  
Christine M. Chresta ◽  
Paul D. Smith ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Apoptosis Induction ◽  
Mek Inhibition ◽  
Human Lung Cancer Cells

Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Lingyan Wang ◽  
Jiayun Hou ◽  
Minghuan Zheng ◽  
Lin Shi
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Retinoic Acid Receptor ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
The Core ◽  
Human Lung Cancer Cells ◽  
Receptor Beta

Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the anti-tumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

EFFECTS OF OPIOIDS AND NICOTINE ON APOPTOSIS IN HUMAN LUNG CANCER CELLS

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 548-552
Author(s):  
Rhoda Maneckjee ◽  
Kathleen Dehen ◽  
John D. Minna
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells
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