Functional role of the osteostatin and nuclear localization signal sequences of parathyroid hormone-related protein (PTHrP) in osteoblastic cells

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S69
Author(s):  
A. Garcia⁎ ◽  
M. Maycas ◽  
D. Lozano ◽  
A. Lopez-Herradon ◽  
S. Portal-Nuñez ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Functional Role ◽  
Osteoblastic Cells ◽  
Related Protein ◽  
Signal Sequences ◽  
Parathyroid Hormone Related Protein ◽  
Localization Signal

scholarly journals Functional Roles of the Nuclear Localization Signal of Parathyroid Hormone-Related Protein (PTHrP) in Osteoblastic Cells

2014 ◽  
Vol 28 (6) ◽  
pp. 925-934 ◽  
Author(s):  
A. García-Martín ◽  
J.A. Ardura ◽  
M. Maycas ◽  
D. Lozano ◽  
A. López-Herradón ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Osteoblastic Cells ◽  
Related Protein ◽  
Functional Roles ◽  
Parathyroid Hormone Related Protein ◽  
Localization Signal

scholarly journals Parathyroid hormone-related protein as predictor of urolithiasis disease development

2020 ◽  
pp. 41-46
Author(s):  
A. A. Budanov ◽  
V. L. Medvedev ◽  
A. N. Kurzanov ◽  
A. A. Basov ◽  
G. A. Palaguta ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Surgical Treatment ◽  
Blood Parameters ◽  
Scientific Research Institute ◽  
Healthy People ◽  
Disease Development ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Recurrent Nephrolithiasis

Background. The present article studies a possible role of parathyroid hormone-related protein (PTHrP) in urolithiasis pathogenesis.Aim. To consider PTHrP level as a predictor of the urolithiasis development.Material and methods. We presented an analysis of treatment in 79 patients with primary and recurrent nephrolithiasis that had underwent surgical treatment in the Uronephrological Center of Scientific Research Institute – Ochapovsky Regional Clinical Hospital #1, Krasnodar from 2017 to 2019. All observed patients were divided in two groups: patients with primary and recurrent nephrolithiasis. A group of 10 relatively healthy people was included in the study as well. All patients and conditionally healthy people had a test for blood parameters; in particular, the level of parathyroid hormone-related protein was assessed in order to compare the indicators in all three groups.Conclusions. The PTHrP level was showed to be statistically significantly different in patients with urolithiasis from the group with relatively healthy people. Groups with primary and recurrent nephrolithiasis show not difference in the level of PTHrP. Further studies are necessary to consider this protein as one of the predictors of urolithiasis and study its role in the pathogenesis of nephrolithiasis.

The role of fetal parathyroid hormone-related protein in transplacental calcium transport

1996 ◽  
Vol 17 (2) ◽  
pp. 159-164 ◽  
Author(s):  
J Tucci ◽  
V Hammond ◽  
P V Senior ◽  
A Gibson ◽  
F Beck
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Pump ◽  
Calcium Deposition ◽  
Related Protein ◽  
Compensatory Mechanisms ◽  
Total Body Calcium ◽  
Parathyroid Hormone Related Protein ◽  
Ionised Calcium ◽  
Total Body

ABSTRACT During pregnancy, a placental calcium pump maintains the fetus in a hypercalcaemic state relative to the mother, a condition which has been thought to facilitate normal development of the fetal skeleton. Based on experiments performed in the sheep, parathyroid hormone-related protein (PTHrP) has been implicated as the hormone responsible for maintaining the placental calcium pump. In the present study on mice in which the PTHrP gene has been ablated by homologous recombination, we have measured both fetal and maternal circulating total and ionised calcium levels, as well as fetal total body calcium, in order to determine whether absence of PTHrP during fetal development has an effect on fetal calcium levels. Our results show that, in fetuses lacking PTHrP, circulating ionised calcium levels are significantly lower than those of heterozygote and wild-type littermates, but circulating total calcium levels show no difference. Total body calcium levels of null mutants are significantly higher than those of normal littermates. The role of PTHrP in maintaining the integrity of the transplacental calcium pump in the rodent thus remains unclear. It may be that the lower levels of fetal blood ionised calcium in mutant animals are due to disruption of the placental pump, but, if this is the case, compensatory mechanisms have operated to allow the excessive calcium deposition seen in the skeletons of these animals. Alternatively, the increased avidity of the bones for calcium may in itself have produced a lower equilibrium level of available ionised calcium.

Evidence for the synthesis of parathyroid hormone-related protein (PTHrP) by nontransformed clonal rat osteoblastic cells in vitro

Bone ◽  
1995 ◽  
Vol 16 (3) ◽  
pp. 341-347 ◽  
Author(s):  
H.L. Guenther ◽  
W. Hofstetter ◽  
J.M. Moseley ◽  
M.T. Gillespie ◽  
N. Suda ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Osteoblastic Cells ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
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